ID   GTHB2_ONCTS             Reviewed;         142 AA.
AC   P07732;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Gonadotropin subunit beta-2;
DE   AltName: Full=GTH-II-beta;
DE   AltName: Full=Gonadotropin beta-II chain;
DE   Flags: Precursor;
GN   Name=cgbb;
OS   Oncorhynchus tshawytscha (Chinook salmon) (Salmo tshawytscha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=74940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2428617; DOI=10.1111/j.1432-1033.1986.tb09930.x;
RA   Trinh K.-Y., Wang N.C., Hew C.-L., Crim L.W.;
RT   "Molecular cloning and sequencing of salmon gonadotropin beta subunit.";
RL   Eur. J. Biochem. 159:619-624(1986).
CC   -!- FUNCTION: Involved in gametogenesis and steroidogenesis.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; X04404; CAA27992.1; -; mRNA.
DR   PIR; A25800; A25800.
DR   AlphaFoldDB; P07732; -.
DR   SMR; P07732; -.
DR   Proteomes; UP000694402; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IMP:AgBase.
DR   GO; GO:0005179; F:hormone activity; IMP:AgBase.
DR   GO; GO:0035941; P:androstenedione secretion; IMP:AgBase.
DR   GO; GO:0042701; P:progesterone secretion; IMP:AgBase.
DR   GO; GO:0061370; P:testosterone biosynthetic process; IMP:AgBase.
DR   GO; GO:0035936; P:testosterone secretion; IMP:AgBase.
DR   CDD; cd00069; GHB_like; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001545; Gonadotropin_bsu.
DR   InterPro; IPR018245; Gonadotropin_bsu_CS.
DR   PANTHER; PTHR11515; PTHR11515; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SMART; SM00068; GHB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR   PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..23
FT   CHAIN           24..142
FT                   /note="Gonadotropin subunit beta-2"
FT                   /id="PRO_0000011703"
FT   CARBOHYD        33
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000305"
FT   DISULFID        29..77
FT                   /evidence="ECO:0000250"
FT   DISULFID        43..92
FT                   /evidence="ECO:0000250"
FT   DISULFID        46..130
FT                   /evidence="ECO:0000250"
FT   DISULFID        54..108
FT                   /evidence="ECO:0000250"
FT   DISULFID        58..110
FT                   /evidence="ECO:0000250"
FT   DISULFID        113..120
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   142 AA;  15903 MW;  BEAEBEBFFD1292F8 CRC64;
     MLGLHVGTLI SLFLCILLEP IEGSLMQPCQ PINQTVSLEK EGCPTCLVIR APICSGHCVT
     KEPVFKSPFS TVYQHVCTYR DVRYEMIRLP DCPPWSDPHV TYPVALSCDC SLCNMDTSDC
     TIESLQPDFC ITQRVLTDGD MW