ID   GTHB2_THUOB             Reviewed;         115 AA.
AC   P37206;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Gonadotropin subunit beta-2;
DE   AltName: Full=GTH-II-beta;
DE   AltName: Full=Gonadotropin beta-II chain;
GN   Name=cgbb;
OS   Thunnus obesus (Bigeye tuna).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Pelagiaria; Scombriformes; Scombridae; Thunnus.
OX   NCBI_TaxID=8241;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pituitary;
RX   PubMed=8138353; DOI=10.1111/j.1399-3011.1994.tb00377.x;
RA   Okada T., Kawazoe I., Kimura S., Sasamoto Y., Aida K., Kawauchi H.;
RT   "Purification and characterization of gonadotropin I and II from pituitary
RT   glands of tuna (Thunnus obesus).";
RL   Int. J. Pept. Protein Res. 43:69-80(1994).
CC   -!- FUNCTION: Involved in gametogenesis and steroidogenesis.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P37206; -.
DR   SMR; P37206; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   CDD; cd00069; GHB_like; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001545; Gonadotropin_bsu.
DR   InterPro; IPR018245; Gonadotropin_bsu_CS.
DR   PANTHER; PTHR11515; PTHR11515; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SMART; SM00068; GHB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR   PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein; Hormone; Secreted.
FT   CHAIN           1..115
FT                   /note="Gonadotropin subunit beta-2"
FT                   /id="PRO_0000149037"
FT   CARBOHYD        10
FT                   /note="N-linked (GlcNAc...) asparagine"
FT   DISULFID        6..54
FT                   /evidence="ECO:0000250"
FT   DISULFID        20..69
FT                   /evidence="ECO:0000250"
FT   DISULFID        23..107
FT                   /evidence="ECO:0000250"
FT   DISULFID        31..85
FT                   /evidence="ECO:0000250"
FT   DISULFID        35..87
FT                   /evidence="ECO:0000250"
FT   DISULFID        90..97
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   115 AA;  12992 MW;  8721C07836F5CAE9 CRC64;
     FQLPPCQLIN QTVSVEKEGC ASCHPVETTI CSGHCITKDP VIKIPFSKVY QHVCTYRDFY
     YKTFELPDCP PGVDPTVTYP VALSCHCGRC AMDTSDCTFE SLQPDFCMND IPFYY