ID   GTHB2_TRITC             Reviewed;         146 AA.
AC   Q9PW98;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Gonadotropin subunit beta-2;
DE   AltName: Full=GTH-II-beta;
DE   AltName: Full=Gonadotropin beta-II chain;
DE   Flags: Precursor;
GN   Name=cgbb;
OS   Trichopodus trichopterus (Three spot gourami) (Trichogaster trichopterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Anabantiformes; Anabantoidei; Osphronemidae; Luciocephalinae;
OC   Trichopodus.
OX   NCBI_TaxID=96903;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10514555; DOI=10.1677/jme.0.0230177;
RA   Jackson K., Goldberg D., Ofir M., Abraham M., Degani G.;
RT   "Blue gourami (Trichogaster trichopterus) gonadotropic beta subunits (I and
RT   II) cDNA sequences and expression during oogenesis.";
RL   J. Mol. Endocrinol. 23:177-187(1999).
CC   -!- FUNCTION: Involved in gametogenesis and steroidogenesis.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; AF157631; AAD51935.1; -; mRNA.
DR   AlphaFoldDB; Q9PW98; -.
DR   SMR; Q9PW98; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   CDD; cd00069; GHB_like; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001545; Gonadotropin_bsu.
DR   InterPro; IPR018245; Gonadotropin_bsu_CS.
DR   PANTHER; PTHR11515; PTHR11515; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SMART; SM00068; GHB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR   PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..146
FT                   /note="Gonadotropin subunit beta-2"
FT                   /id="PRO_0000011705"
FT   CARBOHYD        41
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        37..85
FT                   /evidence="ECO:0000250"
FT   DISULFID        51..100
FT                   /evidence="ECO:0000250"
FT   DISULFID        54..138
FT                   /evidence="ECO:0000250"
FT   DISULFID        62..116
FT                   /evidence="ECO:0000250"
FT   DISULFID        66..118
FT                   /evidence="ECO:0000250"
FT   DISULFID        121..128
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   146 AA;  16411 MW;  3924B43E8ECBBECC CRC64;
     MTVEISKVFV LMMLNLFLGA SSSIWSVAPA AFQLPPCQLI NQTVSLEKEG CPRCHAVETT
     ICSGHCLTKD PIIKIPFSNV YQHVCTYRDL FYKTFEFPDC PPGVDPVVTY PVALSCHCSR
     CVMDTSDCTF ESLQPDFCMN DIPFYY