ID   GTHB_MURCI              Reviewed;         113 AA.
AC   P12837;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Gonadotropin subunit beta;
DE   AltName: Full=Gonadotropin beta chain;
GN   Name=cgb;
OS   Muraenesox cinereus (Daggertooth pike conger) (Muraena cinerea).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Anguilliformes; Muraenesocidae;
OC   Muraenesox.
OX   NCBI_TaxID=7946;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pituitary;
RX   PubMed=2598923; DOI=10.1111/j.1432-1033.1989.tb15183.x;
RA   Liu C.-S., Huang F.-L., Chang Y.-S., Lo T.-B.;
RT   "Pike eel (Muraenesox cinereus) gonadotropin. Amino acid sequences of both
RT   alpha and beta subunits.";
RL   Eur. J. Biochem. 186:105-114(1989).
CC   -!- FUNCTION: Involved in gametogenesis and steroidogenesis.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC       {ECO:0000305}.
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DR   PIR; S07092; S07092.
DR   AlphaFoldDB; P12837; -.
DR   SMR; P12837; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   CDD; cd00069; GHB_like; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001545; Gonadotropin_bsu.
DR   InterPro; IPR018245; Gonadotropin_bsu_CS.
DR   PANTHER; PTHR11515; PTHR11515; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SMART; SM00068; GHB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR   PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein; Hormone; Secreted.
FT   CHAIN           1..113
FT                   /note="Gonadotropin subunit beta"
FT                   /id="PRO_0000149035"
FT   CARBOHYD        10
FT                   /note="N-linked (GlcNAc...) asparagine"
FT   DISULFID        6..54
FT                   /evidence="ECO:0000250"
FT   DISULFID        20..69
FT                   /evidence="ECO:0000250"
FT   DISULFID        23..107
FT                   /evidence="ECO:0000250"
FT   DISULFID        31..85
FT                   /evidence="ECO:0000250"
FT   DISULFID        35..87
FT                   /evidence="ECO:0000250"
FT   DISULFID        90..97
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   113 AA;  12582 MW;  17DDD0ADF6ACA6F7 CRC64;
     SVLQPCQPIN ETISVEKDGC PKCLVFQTSI CSGHCITKDP SYKSPLSTVY QRVCTYRDVR
     YETVRLPDCR PGVDPHVTFP VALSCDCNLC TMDTSDCAIQ SLRPDFCMSQ RAP