GTP1_SCHPO
ID GTP1_SCHPO Reviewed; 364 AA.
AC P32235; O43016; O59756;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2001, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=GTP-binding protein 1;
GN Name=gtp1; ORFNames=SPBC354.01, SPBC649.06;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8462872; DOI=10.1016/0378-1119(93)90327-y;
RA Hudson J.D., Young P.G.;
RT "Sequence of the Schizosaccharomyces pombe gtp1 gene and identification of
RT a novel family of putative GTP-binding proteins.";
RL Gene 125:191-193(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- SIMILARITY: Belongs to the TRAFAC class OBG-HflX-like GTPase
CC superfamily. OBG GTPase family. {ECO:0000255|PROSITE-ProRule:PRU01047}.
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DR EMBL; L00671; AAA35308.1; -; Genomic_DNA.
DR EMBL; CU329671; CAA19048.2; -; Genomic_DNA.
DR PIR; JT0741; JT0741.
DR PIR; T40281; T40281.
DR PIR; T40599; T40599.
DR RefSeq; NP_595225.2; NM_001021131.2.
DR AlphaFoldDB; P32235; -.
DR SMR; P32235; -.
DR STRING; 4896.SPBC354.01.1; -.
DR MaxQB; P32235; -.
DR PaxDb; P32235; -.
DR PRIDE; P32235; -.
DR GeneID; 2540303; -.
DR KEGG; spo:SPBC354.01; -.
DR PomBase; SPBC354.01; gtp1.
DR eggNOG; KOG1486; Eukaryota.
DR HOGENOM; CLU_044997_0_0_1; -.
DR InParanoid; P32235; -.
DR PhylomeDB; P32235; -.
DR PRO; PR:P32235; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0051286; C:cell tip; HDA:PomBase.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0002181; P:cytoplasmic translation; ISO:PomBase.
DR CDD; cd01896; DRG; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR045001; DRG.
DR InterPro; IPR031167; G_OBG.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR031662; GTP-binding_2.
DR InterPro; IPR006074; GTP1-OBG_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR PANTHER; PTHR43127; PTHR43127; 1.
DR Pfam; PF01926; MMR_HSR1; 1.
DR Pfam; PF16897; MMR_HSR1_Xtn; 1.
DR Pfam; PF02824; TGS; 1.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF81271; SSF81271; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51710; G_OBG; 1.
DR PROSITE; PS00905; GTP1_OBG; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW GTP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..364
FT /note="GTP-binding protein 1"
FT /id="PRO_0000205431"
FT DOMAIN 63..287
FT /note="OBG-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT DOMAIN 287..363
FT /note="TGS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01228"
FT BINDING 69..76
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT BINDING 115..119
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT BINDING 246..249
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT CONFLICT 146..156
FT /note="LDATKAADQRE -> FGCYKKLPISEK (in Ref. 1; AAA35308)"
FT /evidence="ECO:0000305"
FT CONFLICT 308..309
FT /note="VR -> IH (in Ref. 1; AAA35308)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 364 AA; 40848 MW; 447B93FDE3CB0830 CRC64;
MGVLEKIQEI EAEMRRTQKN KATEYHLGLL KGKLAKLRAQ LLEPTSKSGP KGEGFDVLKS
GDARVAFIGF PSVGKSTLLS AITKTKSATA SYEFTTLTAI PGVLEYDGAE IQMLDLPGII
EGASQGRGGR QAVSAARTAD LILMVLDATK AADQREKIEY ELEQVGIRLN RQPPNVTLTI
KKNGGIKFNH TVPLTHMDYK MAYNILHEYR IHNADILIRE DITVDDFIDL VMGNRRYINC
LYCYSKIDAV SLEEVDRLAR LPKSVVISCN MKLNLDFLKE RIWEELNLYR IYTKRKGEMP
DFSEALIVRK GSTIEQVCNR IHRTLAEQLK YALVWGTSAK HSPQVVVGLN HRVEEGDVVT
IVTK
