GTPA_DICDI
ID GTPA_DICDI Reviewed; 449 AA.
AC Q552Z6; Q86H40;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=GTP-binding protein A;
GN Name=gtpA; ORFNames=DDB_G0275441;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family.
CC IAN subfamily. {ECO:0000305}.
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DR EMBL; AAFI02000013; EAL69471.1; -; Genomic_DNA.
DR RefSeq; XP_643524.1; XM_638432.1.
DR AlphaFoldDB; Q552Z6; -.
DR SMR; Q552Z6; -.
DR STRING; 44689.DDB0191350; -.
DR PaxDb; Q552Z6; -.
DR EnsemblProtists; EAL69471; EAL69471; DDB_G0275441.
DR GeneID; 8620106; -.
DR KEGG; ddi:DDB_G0275441; -.
DR dictyBase; DDB_G0275441; gtpA.
DR eggNOG; ENOG502QSV2; Eukaryota.
DR HOGENOM; CLU_610345_0_0_1; -.
DR InParanoid; Q552Z6; -.
DR OMA; VYAMENS; -.
DR PhylomeDB; Q552Z6; -.
DR PRO; PR:Q552Z6; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR006703; G_AIG1.
DR InterPro; IPR045058; GIMA/IAN/Toc.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10903; PTHR10903; 1.
DR Pfam; PF04548; AIG1; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51720; G_AIG1; 1.
PE 3: Inferred from homology;
KW GTP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..449
FT /note="GTP-binding protein A"
FT /id="PRO_0000388642"
FT DOMAIN 149..386
FT /note="AIG1-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 158..165
FT /note="G1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT REGION 183..187
FT /note="G2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT REGION 204..207
FT /note="G3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT REGION 275..278
FT /note="G4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT REGION 336..338
FT /note="G5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT COMPBIAS 1..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..77
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 158..165
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
SQ SEQUENCE 449 AA; 49634 MW; 2BAAB39ADE12CB4A CRC64;
MFNINPYKSK TTKSSSSSSA SPKSSKISNV SGSGSSSSSS SSSSSSSKDK DKDKRKKSFL
KDDSVPSLSS KTENSLSLTS LSEITQSMTN TQTQTATDAS MTAEDVSEIG EDYDPFLSIL
EEPGVDGATI EKETTEELQE MLAVLKGVQN ECNVLLLGRT GVGKSSTLNT VFGIDIPVHS
SESCTQDPFT YSRVVNGFKL NIIDTPGFLD SQGELVDSNN MIKIQRYLSG KTIHCVLFVE
KFTETRFDGA HQLVINQFTE KLGPQLWRNA AVVLTYANSV LPDSCYDGFD EEDDVGPWKK
HYEARALQFR KFFAGILAQL PQDDYPPKHI PVYAMENSRR CKRNEQGQRV LIDGTPCLHL
LISGLLKMVD PKTAFLFMGH LRAKNKPGRG HRGDQNDREL SIMDNITEIL KLFIVPPFDQ
LGKGTVAKIL ENWGKKLDKY GNLPNLLKI
