GTPB2_HUMAN
ID GTPB2_HUMAN Reviewed; 602 AA.
AC Q9BX10; Q5T7E8; Q8ND84; Q8TAH7; Q8WUA5; Q9HCS9; Q9NRU4; Q9NX60;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=GTP-binding protein 2;
GN Name=GTPBP2 {ECO:0000312|EMBL:CAC36269.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAB12431.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND TISSUE SPECIFICITY.
RX PubMed=11054535; DOI=10.1016/s0378-1119(00)00346-2;
RA Watanabe M., Yoshida K., Hida M., Kato H., Uchida K., Yamaguchi R.,
RA Tateyama S., Sugano S.;
RT "Cloning, expression analysis, and chromosomal mapping of GTPBP2, a novel
RT member of the G protein family.";
RL Gene 256:51-58(2000).
RN [2] {ECO:0000312|EMBL:CAC36269.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3] {ECO:0000305, ECO:0000312|EMBL:BAA91160.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4] {ECO:0000305, ECO:0000312|EMBL:AAH64968.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Colon {ECO:0000312|EMBL:AAH20980.2},
RC Ovary {ECO:0000312|EMBL:AAH28347.2}, and
RC Skin {ECO:0000312|EMBL:AAH64968.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5] {ECO:0000305, ECO:0000312|EMBL:AAF78884.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 41-602 (ISOFORM 1), AND INDUCTION.
RX PubMed=10833435; DOI=10.1006/bbrc.2000.2763;
RA Kudo H., Senju S., Mitsuya H., Nishimura Y.;
RT "Mouse and human GTPBP2, newly identified members of the GP-1 family of
RT GTPase.";
RL Biochem. Biophys. Res. Commun. 272:456-465(2000).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 46-602 (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [7]
RP INVOLVEMENT IN JABELS.
RX PubMed=26675814; DOI=10.1016/j.neurobiolaging.2015.10.034;
RA Jaberi E., Rohani M., Shahidi G.A., Nafissi S., Arefian E., Soleimani M.,
RA Rasooli P., Ahmadieh H., Daftarian N., KaramiNejadRanjbar M., Klotzle B.,
RA Fan J.B., Turk C., Steemers F., Elahi E.;
RT "Identification of mutation in GTPBP2 in patients of a family with
RT neurodegeneration accompanied by iron deposition in the brain.";
RL Neurobiol. Aging 38:216.E11-216.E18(2016).
RN [8]
RP INVOLVEMENT IN JABELS, AND VARIANTS JABELS 144-ARG--PHE-602 DEL;
RP 407-GLN--PHE-602 DEL AND 470-ARG--PHE-602 DEL.
RX PubMed=29449720; DOI=10.1038/s41431-018-0097-3;
RA Bertoli-Avella A.M., Garcia-Aznar J.M., Brandau O., Al-Hakami F.,
RA Yueksel Z., Marais A., Gruening N.M., Abbasi Moheb L., Paknia O.,
RA Alshaikh N., Alameer S., Marafi M.J., Al-Mulla F., Al-Sannaa N., Rolfs A.,
RA Bauer P.;
RT "Biallelic inactivating variants in the GTPBP2 gene cause a
RT neurodevelopmental disorder with severe intellectual disability.";
RL Eur. J. Hum. Genet. 26:592-598(2018).
CC -!- INTERACTION:
CC Q9BX10; P49760: CLK2; NbExp=3; IntAct=EBI-6115579, EBI-750020;
CC Q9BX10; Q9UHW5: GPN3; NbExp=3; IntAct=EBI-6115579, EBI-395491;
CC Q9BX10; Q9BX10: GTPBP2; NbExp=3; IntAct=EBI-6115579, EBI-6115579;
CC Q9BX10; O60341: KDM1A; NbExp=2; IntAct=EBI-6115579, EBI-710124;
CC Q9BX10; Q9UBU9: NXF1; NbExp=3; IntAct=EBI-6115579, EBI-398874;
CC Q9BX10; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-6115579, EBI-79165;
CC Q9BX10; Q9H8W4: PLEKHF2; NbExp=3; IntAct=EBI-6115579, EBI-742388;
CC Q9BX10; O14744: PRMT5; NbExp=2; IntAct=EBI-6115579, EBI-351098;
CC Q9BX10; Q96LA8: PRMT6; NbExp=2; IntAct=EBI-6115579, EBI-912440;
CC Q9BX10; P20618: PSMB1; NbExp=3; IntAct=EBI-6115579, EBI-372273;
CC Q9BX10; P08621: SNRNP70; NbExp=3; IntAct=EBI-6115579, EBI-1049228;
CC Q9BX10; O43463: SUV39H1; NbExp=2; IntAct=EBI-6115579, EBI-349968;
CC Q9BX10; Q99757: TXN2; NbExp=5; IntAct=EBI-6115579, EBI-2932492;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1 {ECO:0000269|PubMed:10833435};
CC IsoId=Q9BX10-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:11054535};
CC IsoId=Q9BX10-2; Sequence=VSP_052154;
CC Name=3 {ECO:0000269|PubMed:14702039};
CC IsoId=Q9BX10-3; Sequence=VSP_052154, VSP_052156;
CC Name=4 {ECO:0000269|PubMed:14574404};
CC IsoId=Q9BX10-4; Sequence=VSP_052155;
CC -!- TISSUE SPECIFICITY: Predominantly expressed in thymus, spleen, and
CC testis. Expressed at lower levels in brain, lung, kidney, and ovary.
CC {ECO:0000269|PubMed:11054535}.
CC -!- INDUCTION: Up-regulated by IFNG/IFN-gamma in human monocytic cell line
CC THP-1. {ECO:0000269|PubMed:10833435}.
CC -!- DISEASE: Jaberi-Elahi syndrome (JABELS) [MIM:617988]: An autosomal
CC recessive disorder characterized by developmental delay and
CC intellectual disability. Additional variable features include ataxic
CC gait and abnormal movements, visual impairment, microcephaly, abnormal
CC foot or hand posturing, kyphoscoliosis, dysmorphic facial features or
CC seizures. Brain imaging typically shows cerebellar atrophy and
CC hypoplasia of the corpus callosum. {ECO:0000269|PubMed:26675814,
CC ECO:0000269|PubMed:29449720}. Note=The disease may be caused by
CC variants affecting the gene represented in this entry.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. GTPBP1
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU01059}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAD38999.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB024574; BAB12431.1; -; mRNA.
DR EMBL; AL353602; CAC36269.1; -; Genomic_DNA.
DR EMBL; AL353602; CAI12785.1; -; Genomic_DNA.
DR EMBL; AK000430; BAA91160.1; -; mRNA.
DR EMBL; BC020980; AAH20980.2; -; mRNA.
DR EMBL; BC028347; AAH28347.2; -; mRNA.
DR EMBL; BC064968; AAH64968.1; -; mRNA.
DR EMBL; AF168990; AAF78884.1; -; mRNA.
DR EMBL; AL834331; CAD38999.1; ALT_INIT; mRNA.
DR CCDS; CCDS4903.1; -. [Q9BX10-1]
DR CCDS; CCDS69124.1; -. [Q9BX10-2]
DR PIR; PC7084; PC7084.
DR RefSeq; NP_001273145.1; NM_001286216.1. [Q9BX10-2]
DR RefSeq; NP_061969.3; NM_019096.4. [Q9BX10-1]
DR AlphaFoldDB; Q9BX10; -.
DR SMR; Q9BX10; -.
DR BioGRID; 120097; 54.
DR IntAct; Q9BX10; 33.
DR MINT; Q9BX10; -.
DR STRING; 9606.ENSP00000303997; -.
DR iPTMnet; Q9BX10; -.
DR PhosphoSitePlus; Q9BX10; -.
DR BioMuta; GTPBP2; -.
DR DMDM; 74752415; -.
DR EPD; Q9BX10; -.
DR jPOST; Q9BX10; -.
DR MassIVE; Q9BX10; -.
DR MaxQB; Q9BX10; -.
DR PaxDb; Q9BX10; -.
DR PeptideAtlas; Q9BX10; -.
DR PRIDE; Q9BX10; -.
DR ProteomicsDB; 79339; -. [Q9BX10-1]
DR ProteomicsDB; 79340; -. [Q9BX10-2]
DR ProteomicsDB; 79341; -. [Q9BX10-3]
DR ProteomicsDB; 79342; -. [Q9BX10-4]
DR Antibodypedia; 30525; 187 antibodies from 27 providers.
DR DNASU; 54676; -.
DR Ensembl; ENST00000307114.11; ENSP00000304893.7; ENSG00000172432.19. [Q9BX10-2]
DR Ensembl; ENST00000307126.10; ENSP00000303997.5; ENSG00000172432.19. [Q9BX10-1]
DR GeneID; 54676; -.
DR KEGG; hsa:54676; -.
DR MANE-Select; ENST00000307126.10; ENSP00000303997.5; NM_019096.5; NP_061969.3.
DR UCSC; uc003ovs.5; human. [Q9BX10-1]
DR CTD; 54676; -.
DR DisGeNET; 54676; -.
DR GeneCards; GTPBP2; -.
DR HGNC; HGNC:4670; GTPBP2.
DR HPA; ENSG00000172432; Low tissue specificity.
DR MalaCards; GTPBP2; -.
DR MIM; 607434; gene.
DR MIM; 617988; phenotype.
DR neXtProt; NX_Q9BX10; -.
DR OpenTargets; ENSG00000172432; -.
DR PharmGKB; PA29058; -.
DR VEuPathDB; HostDB:ENSG00000172432; -.
DR eggNOG; KOG1143; Eukaryota.
DR GeneTree; ENSGT00940000155636; -.
DR HOGENOM; CLU_012821_1_1_1; -.
DR InParanoid; Q9BX10; -.
DR OMA; DYACLVI; -.
DR PhylomeDB; Q9BX10; -.
DR TreeFam; TF350446; -.
DR PathwayCommons; Q9BX10; -.
DR Reactome; R-HSA-114608; Platelet degranulation.
DR SignaLink; Q9BX10; -.
DR BioGRID-ORCS; 54676; 30 hits in 1084 CRISPR screens.
DR ChiTaRS; GTPBP2; human.
DR GenomeRNAi; 54676; -.
DR Pharos; Q9BX10; Tbio.
DR PRO; PR:Q9BX10; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q9BX10; protein.
DR Bgee; ENSG00000172432; Expressed in lower esophagus mucosa and 169 other tissues.
DR ExpressionAtlas; Q9BX10; baseline and differential.
DR Genevisible; Q9BX10; HS.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0031093; C:platelet alpha granule lumen; TAS:Reactome.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0003746; F:translation elongation factor activity; IBA:GO_Central.
DR GO; GO:0006414; P:translational elongation; IBA:GO_Central.
DR CDD; cd04165; GTPBP1_like; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR035531; GTPBP1-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR Pfam; PF00009; GTP_EFTU; 1.
DR SUPFAM; SSF50447; SSF50447; 1.
DR SUPFAM; SSF50465; SSF50465; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Disease variant; GTP-binding;
KW Intellectual disability; Nucleotide-binding; Reference proteome.
FT CHAIN 1..602
FT /note="GTP-binding protein 2"
FT /id="PRO_0000248500"
FT DOMAIN 170..398
FT /note="tr-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01059"
FT REGION 16..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 179..186
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:O00178"
FT BINDING 260..264
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:O00178"
FT BINDING 316..319
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:O00178"
FT VAR_SEQ 1..88
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:11054535,
FT ECO:0000303|PubMed:14702039"
FT /id="VSP_052154"
FT VAR_SEQ 72..79
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14574404"
FT /id="VSP_052155"
FT VAR_SEQ 101..370
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_052156"
FT VARIANT 144..602
FT /note="Missing (in JABELS; unknown pathological
FT significance)"
FT /evidence="ECO:0000269|PubMed:29449720"
FT /id="VAR_080975"
FT VARIANT 407..602
FT /note="Missing (in JABELS; unknown pathological
FT significance)"
FT /evidence="ECO:0000269|PubMed:29449720"
FT /id="VAR_080976"
FT VARIANT 470..602
FT /note="Missing (in JABELS; unknown pathological
FT significance)"
FT /evidence="ECO:0000269|PubMed:29449720"
FT /id="VAR_080977"
FT CONFLICT 42..43
FT /note="KK -> TR (in Ref. 5; AAF78884)"
FT /evidence="ECO:0000305"
FT CONFLICT 234
FT /note="G -> E (in Ref. 1; BAB12431)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 602 AA; 65768 MW; BA9CA08F3797A7B1 CRC64;
MDSRVSELFG GCCRPGGGPA VGGTLKARGA GSSSGCGGPK GKKKNGRNRG GKANNPPYLP
PEAEDGNIEY KLKLVNPSQY RFEHLVTQMK WRLQEGRGEA VYQIGVEDNG LLVGLAEEEM
RASLKTLHRM AEKVGADITV LREREVDYDS DMPRKITEVL VRKVPDNQQF LDLRVAVLGN
VDSGKSTLLG VLTQGELDNG RGRARLNLFR HLHEIQSGRT SSISFEILGF NSKGEVVNYS
DSRTAEEICE SSSKMITFID LAGHHKYLHT TIFGLTSYCP DCALLLVSAN TGIAGTTREH
LGLALALKVP FFIVVSKIDL CAKTTVERTV RQLERVLKQP GCHKVPMLVT SEDDAVTAAQ
QFAQSPNVTP IFTLSSVSGE SLDLLKVFLN ILPPLTNSKE QEELMQQLTE FQVDEIYTVP
EVGTVVGGTL SSGICREGDQ LVVGPTDDGC FLELRVCSIQ RNRSACRVLR AGQAATLALG
DFDRALLRKG MVMVSPEMNP TICSVFEAEI VLLFHATTFR RGFQVTVHVG NVRQTAVVEK
IHAKDKLRTG EKAVVRFRFL KHPEYLKVGA KLLFREGVTK GIGHVTDVQA ITAGEAQANM
GF
