GTPB6_MOUSE
ID GTPB6_MOUSE Reviewed; 514 AA.
AC Q3U6U5; Q3TX13; Q3UMM2;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Putative GTP-binding protein 6;
GN Name=Gtpbp6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, and Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU01042};
CC -!- SIMILARITY: Belongs to the TRAFAC class OBG-HflX-like GTPase
CC superfamily. HflX GTPase family. {ECO:0000255|PROSITE-
CC ProRule:PRU01042}.
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DR EMBL; AK144812; BAE26076.1; -; mRNA.
DR EMBL; AK152225; BAE31052.1; -; mRNA.
DR EMBL; AK152972; BAE31629.1; -; mRNA.
DR EMBL; AK159462; BAE35103.1; -; mRNA.
DR CCDS; CCDS51604.1; -.
DR RefSeq; NP_660129.2; NM_145147.5.
DR AlphaFoldDB; Q3U6U5; -.
DR SMR; Q3U6U5; -.
DR STRING; 10090.ENSMUSP00000076458; -.
DR iPTMnet; Q3U6U5; -.
DR PhosphoSitePlus; Q3U6U5; -.
DR MaxQB; Q3U6U5; -.
DR PaxDb; Q3U6U5; -.
DR PeptideAtlas; Q3U6U5; -.
DR PRIDE; Q3U6U5; -.
DR ProteomicsDB; 271184; -.
DR DNASU; 107999; -.
DR GeneID; 107999; -.
DR KEGG; mmu:107999; -.
DR UCSC; uc008ypr.2; mouse.
DR CTD; 8225; -.
DR MGI; MGI:1306825; Gtpbp6.
DR eggNOG; KOG0410; Eukaryota.
DR InParanoid; Q3U6U5; -.
DR OrthoDB; 1121388at2759; -.
DR TreeFam; TF315022; -.
DR BioGRID-ORCS; 107999; 2 hits in 70 CRISPR screens.
DR ChiTaRS; Gtpbp6; mouse.
DR PRO; PR:Q3U6U5; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q3U6U5; protein.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR CDD; cd01878; HflX; 1.
DR Gene3D; 3.40.50.11060; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR030394; G_HFLX_dom.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR032305; GTP-bd_M.
DR InterPro; IPR016496; GTPase_HflX.
DR InterPro; IPR025121; GTPase_HflX_N.
DR InterPro; IPR042108; GTPase_HflX_N_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10229; PTHR10229; 1.
DR Pfam; PF16360; GTP-bdg_M; 1.
DR Pfam; PF13167; GTP-bdg_N; 1.
DR Pfam; PF01926; MMR_HSR1; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR03156; GTP_HflX; 1.
DR PROSITE; PS51705; G_HFLX; 1.
PE 1: Evidence at protein level;
KW GTP-binding; Magnesium; Metal-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..514
FT /note="Putative GTP-binding protein 6"
FT /id="PRO_0000304799"
FT DOMAIN 285..449
FT /note="Hflx-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01042"
FT REGION 48..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 298
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01042"
FT BINDING 319
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01042"
FT CONFLICT 350
FT /note="N -> S (in Ref. 1; BAE26076/BAE35103)"
FT /evidence="ECO:0000305"
FT CONFLICT 501
FT /note="R -> G (in Ref. 1; BAE35103)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 514 AA; 56475 MW; 95774C6439C0B3E6 CRC64;
MLFLRAAVLP GFWLPRVRRV QLVRSPAVTL PSPVRTVHAG SRVWGSAWAG GGPVRGGGEE
DPREDEEEEE DELLRAPPLL PLDTQRVCVL HPDVKRPAGK KPRSTAEWQV AEAAALVRAL
PGWSVASTLV VPSAAPGSRL VFGKGNFQDV TEKIKGCQDI TSVFLNVERM APPTKKELES
AWGLRVFDRF TLVLHIFRCN ARTREARMQL ALAEIPLLRS SVNTDSGQQD QQGWGSRYIM
GSGESPTELR ARALRDRELR LRRVLERLRD KRRLMRKERV RREFPVVSVV GYTNCGKTTL
IQALTGEAAL QPRDQPFATL DVTVHAGLLP SRLRILYVDT IGFLSQLPHN LIHAFSATLE
DVAYSDVLVH VTDVSHPDAE LQKATVLSTL RGLHLPPALL ESALEVHSKV DLVPGYTPPC
SGALAVSAIS GRGLDELKAA LEASVLRATG RQVLTLCVRL GGPQLGWLYK EAVVQQVQEL
PEGDAAHVTV VITQAAYGRF RKLFPIDAPS ALPH
