ID   GTPB6_XENLA             Reviewed;         527 AA.
AC   Q6DCC6;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Putative GTP-binding protein 6;
GN   Name=gtpbp6;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU01042};
CC   -!- SIMILARITY: Belongs to the TRAFAC class OBG-HflX-like GTPase
CC       superfamily. HflX GTPase family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01042}.
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DR   EMBL; BC078122; AAH78122.1; -; mRNA.
DR   RefSeq; NP_001087175.1; NM_001093706.1.
DR   AlphaFoldDB; Q6DCC6; -.
DR   SMR; Q6DCC6; -.
DR   BioGRID; 103924; 1.
DR   IntAct; Q6DCC6; 1.
DR   DNASU; 447064; -.
DR   GeneID; 447064; -.
DR   KEGG; xla:447064; -.
DR   CTD; 447064; -.
DR   Xenbase; XB-GENE-967570; gtpbp6.S.
DR   OrthoDB; 1121388at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 447064; Expressed in egg cell and 18 other tissues.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd01878; HflX; 1.
DR   Gene3D; 3.40.50.11060; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR030394; G_HFLX_dom.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR032305; GTP-bd_M.
DR   InterPro; IPR016496; GTPase_HflX.
DR   InterPro; IPR025121; GTPase_HflX_N.
DR   InterPro; IPR042108; GTPase_HflX_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10229; PTHR10229; 1.
DR   Pfam; PF16360; GTP-bdg_M; 1.
DR   Pfam; PF13167; GTP-bdg_N; 1.
DR   Pfam; PF01926; MMR_HSR1; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03156; GTP_HflX; 1.
DR   PROSITE; PS51705; G_HFLX; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Magnesium; Metal-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..527
FT                   /note="Putative GTP-binding protein 6"
FT                   /id="PRO_0000304800"
FT   DOMAIN          306..470
FT                   /note="Hflx-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01042"
FT   BINDING         312..319
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01042"
FT   BINDING         319
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01042"
FT   BINDING         338..342
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01042"
FT   BINDING         340
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01042"
FT   BINDING         360..363
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01042"
FT   BINDING         429..432
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01042"
FT   BINDING         448..450
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01042"
SQ   SEQUENCE   527 AA;  59164 MW;  EC526F6EEE462DDE CRC64;
     MLLVRASRAV RCCCSYSLHK TVTFQARHSL YSAHKVHSNG HFHLPLSGIR CFFSGSPYWK
     AKKHGGEHSK AGNLTAIDDY WLEEVEEELE DLDLSPHTAS LLQGAHRVFI VHPDVKWGAK
     KDQLSTADLQ VAEAAALVHS LPNWSVVNTL IMSTKSPDSK LIFGKGNFQT LTDVIKGHPQ
     ITAVFLNVER LSSLTEKEME EAWGVKVFDR YTVVLNIFRF NAHTKEAKLQ IALAELPLLR
     SSLKNETAHM DQQGGGSRYI MGSGETFLEV QQRLLKEREI KIKYALEKVK KKRNLLRTQR
     RRREFPIISI LGYTNSGKTT LIKALTGDEG LQPRDQLFAT LDVTSHAGLL PCHMPVIYVD
     TIGFLSQLPH NLIESFSATL EDVVHSDLLI HVRDISHPET TKQKASVLSV LKNLGLPQQL
     LDTMIEVQNK IDLIDMPENT EDSVLSVSAL HGHGLEDLKQ QVETAVMKST GRNVVTIKVN
     LESPQLSWLY KEASVQEVKV LPEDGTARVR VIITNSAYGK YRKLFCK