GTPB8_BOVIN
ID GTPB8_BOVIN Reviewed; 288 AA.
AC Q0P5E7;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=GTP-binding protein 8;
GN Name=GTPBP8;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal medulla;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. EngB GTPase family. {ECO:0000305}.
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DR EMBL; BC120144; AAI20145.1; -; mRNA.
DR RefSeq; NP_001069296.1; NM_001075828.2.
DR AlphaFoldDB; Q0P5E7; -.
DR SMR; Q0P5E7; -.
DR STRING; 9913.ENSBTAP00000032259; -.
DR PaxDb; Q0P5E7; -.
DR PRIDE; Q0P5E7; -.
DR Ensembl; ENSBTAT00000032325; ENSBTAP00000032259; ENSBTAG00000006534.
DR GeneID; 522329; -.
DR KEGG; bta:522329; -.
DR CTD; 29083; -.
DR VEuPathDB; HostDB:ENSBTAG00000006534; -.
DR VGNC; VGNC:55158; GTPBP8.
DR eggNOG; KOG2486; Eukaryota.
DR GeneTree; ENSGT00390000001083; -.
DR HOGENOM; CLU_033732_5_0_1; -.
DR InParanoid; Q0P5E7; -.
DR OMA; YPFSGLE; -.
DR OrthoDB; 573373at2759; -.
DR TreeFam; TF331089; -.
DR Proteomes; UP000009136; Chromosome 1.
DR Bgee; ENSBTAG00000006534; Expressed in conceptus and 103 other tissues.
DR ExpressionAtlas; Q0P5E7; baseline.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01876; YihA_EngB; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00321; GTPase_EngB; 1.
DR InterPro; IPR030393; G_ENGB_dom.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR019987; GTP-bd_ribosome_bio_YsxC.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01926; MMR_HSR1; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR03598; GTPase_YsxC; 1.
DR PROSITE; PS51706; G_ENGB; 1.
PE 2: Evidence at transcript level;
KW GTP-binding; Magnesium; Metal-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..288
FT /note="GTP-binding protein 8"
FT /id="PRO_0000338611"
FT DOMAIN 109..282
FT /note="EngB-type G"
FT BINDING 117..124
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 124
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250"
FT BINDING 146..150
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 148
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250"
FT BINDING 164..167
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 226..229
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 261..263
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
SQ SEQUENCE 288 AA; 32566 MW; A179D8C9B7C73526 CRC64;
MAAHRLRQSV GRLFAMGPEL GSGRRAFSAF QAFTEVLRLP SKQLTKLVFP LEELHEHFVP
GSRPDLHLNI FHPSLEDIAR AESFFTASAR NRIEYLTSAV RLDHAPDLHR PEVCFIGRSN
VGKSSLIKAL FSLAPEVEVR VSKKPGHTKK LNFYKVGKYF TLVDMPGYGY RAPEDFVDMV
ETYLKERKNL MRTFLLVDSV VGIQKADNIA IEMCEEFALP YVMVLTKIDK PSKGHLLKQV
LQIQKFVDTK TQGCFPQLFP VSAMTYSGIH LLRCFIADIT GNLKTTGF
