GTPB8_RAT
ID GTPB8_RAT Reviewed; 285 AA.
AC Q5BK22;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=GTP-binding protein 8;
GN Name=Gtpbp8;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. EngB GTPase family. {ECO:0000305}.
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DR EMBL; BC091236; AAH91236.1; -; mRNA.
DR RefSeq; NP_001020186.1; NM_001025015.1.
DR AlphaFoldDB; Q5BK22; -.
DR STRING; 10116.ENSRNOP00000002797; -.
DR PaxDb; Q5BK22; -.
DR Ensembl; ENSRNOT00000002797; ENSRNOP00000002797; ENSRNOG00000002044.
DR GeneID; 360714; -.
DR KEGG; rno:360714; -.
DR UCSC; RGD:1310025; rat.
DR CTD; 29083; -.
DR RGD; 1310025; Gtpbp8.
DR eggNOG; KOG2486; Eukaryota.
DR GeneTree; ENSGT00390000001083; -.
DR HOGENOM; CLU_033732_5_0_1; -.
DR InParanoid; Q5BK22; -.
DR OMA; YPFSGLE; -.
DR OrthoDB; 573373at2759; -.
DR PhylomeDB; Q5BK22; -.
DR TreeFam; TF331089; -.
DR PRO; PR:Q5BK22; -.
DR Proteomes; UP000002494; Chromosome 11.
DR Bgee; ENSRNOG00000002044; Expressed in quadriceps femoris and 19 other tissues.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01876; YihA_EngB; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00321; GTPase_EngB; 1.
DR InterPro; IPR030393; G_ENGB_dom.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR019987; GTP-bd_ribosome_bio_YsxC.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01926; MMR_HSR1; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR03598; GTPase_YsxC; 1.
DR PROSITE; PS51706; G_ENGB; 1.
PE 2: Evidence at transcript level;
KW GTP-binding; Magnesium; Metal-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..285
FT /note="GTP-binding protein 8"
FT /id="PRO_0000338614"
FT DOMAIN 110..283
FT /note="EngB-type G"
FT BINDING 118..125
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 125
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250"
FT BINDING 147..151
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 149
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250"
FT BINDING 165..168
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 227..230
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 262..264
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
SQ SEQUENCE 285 AA; 32232 MW; 963C8A7D83109145 CRC64;
MAATRLWHRT GRLLEIASAF GPWPGVYSTS PAFAEVLRMP QKQLRKVVYP LRELEQHLVT
DSRPGLIEQR LFDPSLEDIG RAESVFAATV RNRIEYLSSA VRLDHAPSLR QPEVCFIGRS
NVGKSSLIKA LFSMAPDVEV RISKKPGHTK KMNFFKVGKH FTLVDMPGYG YRAPEDFVDM
VETYLKERNN LKRTFLLVDS VVGITKLDNI AIEMCEEFAL PYVMILTKID KSSKGYLLKQ
VLQIQEFVNT QTQGCFPQLF PISAVTYSGV HLLKCFIADI TGSLK
