GTPBA_BOVIN
ID GTPBA_BOVIN Reviewed; 387 AA.
AC Q3MHG6;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=GTP-binding protein 10;
GN Name=GTPBP10;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hypothalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in the ribosome maturation process.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus. Note=Found in the dense
CC fibrillar compartment region of the nucleolus. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TRAFAC class OBG-HflX-like GTPase
CC superfamily. OBG GTPase family. {ECO:0000255|PROSITE-ProRule:PRU01047}.
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DR EMBL; BC105245; AAI05246.1; -; mRNA.
DR RefSeq; NP_001073783.1; NM_001080314.2.
DR AlphaFoldDB; Q3MHG6; -.
DR SMR; Q3MHG6; -.
DR STRING; 9913.ENSBTAP00000043009; -.
DR PaxDb; Q3MHG6; -.
DR PRIDE; Q3MHG6; -.
DR GeneID; 613957; -.
DR KEGG; bta:613957; -.
DR CTD; 85865; -.
DR eggNOG; KOG1489; Eukaryota.
DR HOGENOM; CLU_011747_2_3_1; -.
DR InParanoid; Q3MHG6; -.
DR OrthoDB; 1150635at2759; -.
DR TreeFam; TF314774; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR CDD; cd01898; Obg; 1.
DR Gene3D; 2.70.210.12; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR031167; G_OBG.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR014100; GTP-bd_Obg/CgtA.
DR InterPro; IPR006169; GTP1_OBG_dom.
DR InterPro; IPR036726; GTP1_OBG_dom_sf.
DR InterPro; IPR045086; OBG_GTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11702; PTHR11702; 2.
DR Pfam; PF01018; GTP1_OBG; 1.
DR Pfam; PF01926; MMR_HSR1; 1.
DR PIRSF; PIRSF002401; GTP_bd_Obg/CgtA; 1.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF82051; SSF82051; 1.
DR PROSITE; PS51710; G_OBG; 1.
DR PROSITE; PS51883; OBG; 1.
PE 2: Evidence at transcript level;
KW GTP-binding; Nucleotide-binding; Nucleus; Reference proteome;
KW Ribosome biogenesis.
FT CHAIN 1..387
FT /note="GTP-binding protein 10"
FT /id="PRO_0000312629"
FT DOMAIN 13..148
FT /note="Obg"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01231"
FT DOMAIN 149..344
FT /note="OBG-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT BINDING 155..162
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT BINDING 202..206
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT BINDING 278..281
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
SQ SEQUENCE 387 AA; 42932 MW; 30571CDBF52CD3DC CRC64;
MVRCSCVLFR KYGNFIDNLR LFTKGGSGGM GYPRLGGEGG KGGDVWVVAH NRMTLKQLKD
KYPQKRFVAG EGANSRVSAL KGSKGKDCEI PVPVGVSVTD ENGKIIGELN KEKDRLLVAE
GGLGGKLLTN FLPLKGQKRV IHLDLKLIAD IGLVGFPNAG KSSLLSKISH AKPAIADYAF
TTIKPELGKI MYSDFKQISV ADLPGLIEGA HMNKGMGHKF LKHIERTKQL LFVVDISGFQ
LSSQTHYRTA FETIILLSKE LELYKEELHT KPALLAVNKM DLPDAQGKFH VLMNQLQNPK
EFFHLFEKNM IPERTVEFQH IIPISAITGE GIDELKNCIR KSLDEHTNQE NDAYHKKQLL
NLHISNTVSY SEPPSKTAVS SPRMDIT
