ID   GTPBA_DROPS             Reviewed;         383 AA.
AC   Q29K06;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=GTP-binding protein 10 homolog;
GN   ORFNames=GA10450;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: May be involved in the ribosome maturation process.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class OBG-HflX-like GTPase
CC       superfamily. OBG GTPase family. {ECO:0000255|PROSITE-ProRule:PRU01047}.
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DR   EMBL; CH379062; EAL32805.1; -; Genomic_DNA.
DR   RefSeq; XP_001355746.1; XM_001355710.3.
DR   AlphaFoldDB; Q29K06; -.
DR   SMR; Q29K06; -.
DR   STRING; 7237.FBpp0285725; -.
DR   EnsemblMetazoa; FBtr0287287; FBpp0285725; FBgn0070507.
DR   GeneID; 4816147; -.
DR   KEGG; dpo:Dpse_GA10450; -.
DR   eggNOG; KOG1489; Eukaryota.
DR   HOGENOM; CLU_011747_2_3_1; -.
DR   InParanoid; Q29K06; -.
DR   OMA; VFMVDIF; -.
DR   PhylomeDB; Q29K06; -.
DR   Proteomes; UP000001819; Chromosome 4.
DR   Bgee; FBgn0070507; Expressed in female reproductive system and 2 other tissues.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR   CDD; cd01898; Obg; 1.
DR   Gene3D; 2.70.210.12; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR031167; G_OBG.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR014100; GTP-bd_Obg/CgtA.
DR   InterPro; IPR006169; GTP1_OBG_dom.
DR   InterPro; IPR036726; GTP1_OBG_dom_sf.
DR   InterPro; IPR045086; OBG_GTPase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11702; PTHR11702; 2.
DR   Pfam; PF01018; GTP1_OBG; 1.
DR   Pfam; PF01926; MMR_HSR1; 1.
DR   PIRSF; PIRSF002401; GTP_bd_Obg/CgtA; 1.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF82051; SSF82051; 1.
DR   PROSITE; PS51710; G_OBG; 1.
DR   PROSITE; PS51883; OBG; 1.
PE   3: Inferred from homology;
KW   GTP-binding; Nucleotide-binding; Nucleus; Reference proteome;
KW   Ribosome biogenesis.
FT   CHAIN           1..383
FT                   /note="GTP-binding protein 10 homolog"
FT                   /id="PRO_0000312636"
FT   DOMAIN          22..157
FT                   /note="Obg"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01231"
FT   DOMAIN          158..353
FT                   /note="OBG-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT   BINDING         164..171
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT   BINDING         211..215
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT   BINDING         287..290
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
SQ   SEQUENCE   383 AA;  41846 MW;  BC60D4CD9A65B030 CRC64;
     MVQIFKFLLK SNKSPARAHF RPSFLDTLRL AVRGGHGGNG LPKYGGVGGQ GGCVYFVAKE
     GLTLRKMAQG LKDRRVAASS GEDSSKVSIF GKRGVDTRIE VPVGVQVYDE QQKLLADLNE
     NDAKCIVAGG GTGGCTGNNF LGRPGENRIV NLDLKLIADV GLVGFPNAGK STLLKAVSNA
     KPKIAAYPFT TIRPQIGTIE YGDLRSISLA DLPGLIEGAH ANFGMGHKFL KHIERTRLLL
     FMVDIFGFQL SPRHPHRDCL ANIYSLNKEL ELYDPSLLEK PCVLLLNKMD KEGAHDILTK
     VKPIIDDLSS GLADCPEEVR PKRVLKFESI VPISAINSTR VTQVKSQLRR TLVRLAEKQF
     VSDGEQIKEQ LQQRVGLVGP RIT