GTPBA_MOUSE
ID GTPBA_MOUSE Reviewed; 366 AA.
AC Q8K013;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=GTP-binding protein 10;
GN Name=Gtpbp10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Egg;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in the ribosome maturation process.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus. Note=Found in the dense
CC fibrillar compartment region of the nucleolus. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TRAFAC class OBG-HflX-like GTPase
CC superfamily. OBG GTPase family. {ECO:0000255|PROSITE-ProRule:PRU01047}.
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DR EMBL; AK139595; BAE24078.1; -; mRNA.
DR EMBL; BC034507; AAH34507.1; -; mRNA.
DR CCDS; CCDS39006.1; -.
DR RefSeq; NP_694756.1; NM_153116.1.
DR AlphaFoldDB; Q8K013; -.
DR SMR; Q8K013; -.
DR BioGRID; 228915; 1.
DR STRING; 10090.ENSMUSP00000111101; -.
DR iPTMnet; Q8K013; -.
DR PhosphoSitePlus; Q8K013; -.
DR EPD; Q8K013; -.
DR MaxQB; Q8K013; -.
DR PaxDb; Q8K013; -.
DR PRIDE; Q8K013; -.
DR ProteomicsDB; 270903; -.
DR Antibodypedia; 15416; 156 antibodies from 21 providers.
DR Ensembl; ENSMUST00000115441; ENSMUSP00000111101; ENSMUSG00000040464.
DR GeneID; 207704; -.
DR KEGG; mmu:207704; -.
DR UCSC; uc008wis.1; mouse.
DR CTD; 85865; -.
DR MGI; MGI:2385599; Gtpbp10.
DR VEuPathDB; HostDB:ENSMUSG00000040464; -.
DR eggNOG; KOG1489; Eukaryota.
DR GeneTree; ENSGT00940000155589; -.
DR InParanoid; Q8K013; -.
DR OMA; VFMVDIF; -.
DR OrthoDB; 1150635at2759; -.
DR PhylomeDB; Q8K013; -.
DR TreeFam; TF314774; -.
DR BioGRID-ORCS; 207704; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Gtpbp10; mouse.
DR PRO; PR:Q8K013; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q8K013; protein.
DR Bgee; ENSMUSG00000040464; Expressed in undifferentiated genital tubercle and 62 other tissues.
DR ExpressionAtlas; Q8K013; baseline and differential.
DR Genevisible; Q8K013; MM.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR CDD; cd01898; Obg; 1.
DR Gene3D; 2.70.210.12; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR031167; G_OBG.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR014100; GTP-bd_Obg/CgtA.
DR InterPro; IPR006169; GTP1_OBG_dom.
DR InterPro; IPR036726; GTP1_OBG_dom_sf.
DR InterPro; IPR045086; OBG_GTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11702; PTHR11702; 2.
DR Pfam; PF01018; GTP1_OBG; 1.
DR Pfam; PF01926; MMR_HSR1; 1.
DR PIRSF; PIRSF002401; GTP_bd_Obg/CgtA; 1.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF82051; SSF82051; 1.
DR PROSITE; PS51710; G_OBG; 1.
DR PROSITE; PS51883; OBG; 1.
PE 2: Evidence at transcript level;
KW GTP-binding; Nucleotide-binding; Nucleus; Reference proteome;
KW Ribosome biogenesis.
FT CHAIN 1..366
FT /note="GTP-binding protein 10"
FT /id="PRO_0000312631"
FT DOMAIN 13..148
FT /note="Obg"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01231"
FT DOMAIN 149..344
FT /note="OBG-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT REGION 346..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 155..162
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT BINDING 202..206
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT BINDING 278..281
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
SQ SEQUENCE 366 AA; 40142 MW; 0A08069F9C3FECF2 CRC64;
MVRCGCALLR KYGNFIDNLR IFTKGGSGGM GYPRLGGEGG RGGDVWVVAH KNMTLKQLKN
KYPQKRFVAG GGANSRVSAL QGSKGKDCEV PAPVGISVTD ENGQVLGELN KEEDRVLVAK
GGLGGKLHTN FLPLKGQKRI VHLDLKVIAD VGLVGFPNAG KSSLLSRVSH ATPVIADYAF
TTLRPELGKI MYNDFKQISV ADLPGLIEGA HMNKGMGHKF LKHLERTRQL LFVVDISGFQ
LSSVTPYRTA FETIILLTKE LELYKEELQT KPALLAINKM DLPDAQVKLQ ELMKQLLSPE
DFLHLFETKM IPEKALEFQH IVPISTVTGE GIAELKSCIR KALDEQDGKE SDAHRSKQLL
NLQSSS
