GTR10_MOUSE
ID GTR10_MOUSE Reviewed; 536 AA.
AC Q8VHD6;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Solute carrier family 2, facilitated glucose transporter member 10 {ECO:0000305};
DE AltName: Full=Glucose transporter type 10 {ECO:0000303|PubMed:11592815};
DE Short=GLUT-10 {ECO:0000303|PubMed:11592815};
GN Name=Slc2a10 {ECO:0000312|MGI:MGI:2156687};
GN Synonyms=Glut10 {ECO:0000303|PubMed:11592815};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Brain;
RX PubMed=11592815; DOI=10.1006/mgme.2001.3212;
RA Dawson P.A., Mychaleckyj J.C., Fossey S.C., Mihic S.J., Craddock A.L.,
RA Bowden D.W.;
RT "Sequence and functional analysis of GLUT10: a glucose transporter in the
RT Type 2 diabetes-linked region of chromosome 20q12-13.1.";
RL Mol. Genet. Metab. 74:186-199(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Heart;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: Facilitative glucose transporter required for the development
CC of the cardiovascular system. {ECO:0000250|UniProtKB:O95528}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glucose(out) = D-glucose(in); Xref=Rhea:RHEA:60376,
CC ChEBI:CHEBI:4167; Evidence={ECO:0000250|UniProtKB:O95528};
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000250|UniProtKB:O95528}; Multi-pass membrane protein
CC {ECO:0000255}. Cytoplasm, perinuclear region
CC {ECO:0000250|UniProtKB:O95528}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY029579; AAK38739.1; -; mRNA.
DR EMBL; AK052156; BAC34861.1; -; mRNA.
DR CCDS; CCDS17083.1; -.
DR RefSeq; NP_569718.1; NM_130451.3.
DR AlphaFoldDB; Q8VHD6; -.
DR SMR; Q8VHD6; -.
DR STRING; 10090.ENSMUSP00000029196; -.
DR PhosphoSitePlus; Q8VHD6; -.
DR PaxDb; Q8VHD6; -.
DR PRIDE; Q8VHD6; -.
DR ProteomicsDB; 270904; -.
DR Antibodypedia; 13253; 162 antibodies from 27 providers.
DR DNASU; 170441; -.
DR Ensembl; ENSMUST00000029196; ENSMUSP00000029196; ENSMUSG00000027661.
DR GeneID; 170441; -.
DR KEGG; mmu:170441; -.
DR UCSC; uc008nxv.2; mouse.
DR CTD; 81031; -.
DR MGI; MGI:2156687; Slc2a10.
DR VEuPathDB; HostDB:ENSMUSG00000027661; -.
DR eggNOG; KOG0254; Eukaryota.
DR GeneTree; ENSGT00940000159430; -.
DR HOGENOM; CLU_001265_30_5_1; -.
DR InParanoid; Q8VHD6; -.
DR OMA; GCIWLPE; -.
DR OrthoDB; 326501at2759; -.
DR PhylomeDB; Q8VHD6; -.
DR TreeFam; TF332408; -.
DR Reactome; R-MMU-189200; Cellular hexose transport.
DR BioGRID-ORCS; 170441; 2 hits in 70 CRISPR screens.
DR ChiTaRS; Slc2a10; mouse.
DR PRO; PR:Q8VHD6; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8VHD6; protein.
DR Bgee; ENSMUSG00000027661; Expressed in humerus cartilage element and 152 other tissues.
DR ExpressionAtlas; Q8VHD6; baseline and differential.
DR Genevisible; Q8VHD6; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:MGI.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0055056; F:D-glucose transmembrane transporter activity; ISO:MGI.
DR GO; GO:0033300; F:dehydroascorbic acid transmembrane transporter activity; ISO:MGI.
DR GO; GO:0005355; F:glucose transmembrane transporter activity; ISO:MGI.
DR GO; GO:0015293; F:symporter activity; IBA:GO_Central.
DR GO; GO:0060840; P:artery development; ISO:MGI.
DR GO; GO:0045454; P:cell redox homeostasis; ISO:MGI.
DR GO; GO:0072359; P:circulatory system development; IBA:GO_Central.
DR GO; GO:0070837; P:dehydroascorbic acid transport; ISO:MGI.
DR GO; GO:0072498; P:embryonic skeletal joint development; ISO:MGI.
DR GO; GO:0098708; P:glucose import across plasma membrane; ISO:MGI.
DR GO; GO:1904659; P:glucose transmembrane transport; ISO:MGI.
DR GO; GO:0032683; P:negative regulation of connective tissue growth factor production; ISO:MGI.
DR GO; GO:0010629; P:negative regulation of gene expression; ISO:MGI.
DR GO; GO:2001045; P:negative regulation of integrin-mediated signaling pathway; ISO:MGI.
DR GO; GO:1902729; P:negative regulation of proteoglycan biosynthetic process; ISO:MGI.
DR GO; GO:0060392; P:negative regulation of SMAD protein signal transduction; ISO:MGI.
DR GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; ISO:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
DR GO; GO:1902730; P:positive regulation of proteoglycan biosynthetic process; ISO:MGI.
DR GO; GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; ISO:MGI.
DR GO; GO:1903053; P:regulation of extracellular matrix organization; ISO:MGI.
DR GO; GO:0043588; P:skin development; ISO:MGI.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 3.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 2.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Membrane; Reference proteome; Sugar transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..536
FT /note="Solute carrier family 2, facilitated glucose
FT transporter member 10"
FT /id="PRO_0000270192"
FT TOPO_DOM 1..15
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 16..36
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 37..48
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 70..82
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 104..107
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..128
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 129..132
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 154..166
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 188..232
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..298
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 299..319
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 320..402
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 403..423
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 424..442
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 443..463
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 464..468
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 469..489
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 490..536
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT BINDING 242..243
FT /ligand="D-glucose"
FT /ligand_id="ChEBI:CHEBI:4167"
FT /evidence="ECO:0000250|UniProtKB:P11169"
FT BINDING 428
FT /ligand="D-glucose"
FT /ligand_id="ChEBI:CHEBI:4167"
FT /evidence="ECO:0000250|UniProtKB:P11169"
SQ SEQUENCE 536 AA; 56579 MW; 789D14FE3C2477A7 CRC64;
MGLRPAVLLL CASVSLLGGL TFGYELAVIS GALLPLQLNF GLSCLEQELL VGSLLLGALL
ASLVGGFLID CYGRRRAILG SNAVLLAGSL ILGLASSLPW LLLGRLSVGF AISLSSMACC
IYVSELVGPR QRGVLVSLYE VGITVGILFS YGLNYVLAGS PWGWRHMFGW AAAPALLQSL
SLFLLPAGAE GTAAPKDLIP LQGRETSKPG LVKPQYSFLD LFRAQDGMWS RTVVGLGLVL
FQQLTGQPNV LYYASTIFRS VGFHGGSSAV LASVGLGTVK VAATLVATGL VDRAGRRVLL
LFGCALMALS VSGIGLVSFA VSLDSGPSCL ATSNASQQVD LPGSSGLLVR SSLPPVLHTN
GDQGQLVLSV TERPIHPVIT ASLGPVLNTA SPVPTSPILE HTLLCWSALV CMMVYVSAFS
VGFGPVTWLV LSEIYPAEIR GRAFAFCSSF NWAANLFISL SFLDLIGAIG LAWTFLLYGL
TAVLGLAFIY LLVPETKGQS LAEIEQQFQT SRFPLNFGHR QRIGIQYHRL DVSSAS
