GTR10_XENLA
ID GTR10_XENLA Reviewed; 553 AA.
AC Q6GN01;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Solute carrier family 2, facilitated glucose transporter member 10 {ECO:0000305};
DE AltName: Full=Glucose transporter type 10 {ECO:0000250|UniProtKB:O95528};
DE Short=GLUT-10 {ECO:0000250|UniProtKB:O95528};
GN Name=slc2a10 {ECO:0000250|UniProtKB:O95528};
GN Synonyms=glut10 {ECO:0000250|UniProtKB:O95528};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Oocyte;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Facilitative glucose transporter required for the development
CC of the cardiovascular system. {ECO:0000250|UniProtKB:O95528}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glucose(out) = D-glucose(in); Xref=Rhea:RHEA:60376,
CC ChEBI:CHEBI:4167; Evidence={ECO:0000250|UniProtKB:O95528};
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000250|UniProtKB:O95528}; Multi-pass membrane protein
CC {ECO:0000255}. Cytoplasm, perinuclear region
CC {ECO:0000250|UniProtKB:O95528}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
CC {ECO:0000305}.
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DR EMBL; BC073721; AAH73721.1; -; mRNA.
DR RefSeq; NP_001086029.1; NM_001092560.1.
DR AlphaFoldDB; Q6GN01; -.
DR SMR; Q6GN01; -.
DR DNASU; 444458; -.
DR GeneID; 444458; -.
DR KEGG; xla:444458; -.
DR CTD; 444458; -.
DR Xenbase; XB-GENE-950495; slc2a10.S.
DR Proteomes; UP000186698; Chromosome 9_10S.
DR Bgee; 444458; Expressed in blastula and 18 other tissues.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 2.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Glycoprotein; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..553
FT /note="Solute carrier family 2, facilitated glucose
FT transporter member 10"
FT /id="PRO_0000270193"
FT TOPO_DOM 1..15
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 16..36
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 37..48
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 70..82
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 104..105
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 127..132
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 154..165
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 187..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..277
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 299..305
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..326
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 327..413
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 414..434
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 435..462
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 463..482
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 483
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 484..504
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 505..553
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 522..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 250..251
FT /ligand="D-glucose"
FT /ligand_id="ChEBI:CHEBI:4167"
FT /evidence="ECO:0000250|UniProtKB:P11169"
FT BINDING 439
FT /ligand="D-glucose"
FT /ligand_id="ChEBI:CHEBI:4167"
FT /evidence="ECO:0000250|UniProtKB:P11169"
FT CARBOHYD 274
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 344
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 351
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 400
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 553 AA; 59995 MW; E087CCDAD8231CF5 CRC64;
MGLRSTTLVL AATSSLLGGL IFGYELGIIS GALLMLKTVF QLTCFEQEAL VSAVLFGALL
ASLIGGFIID RSGRRTSIMG SNLVVLAGSI ILIATSSFWW LVVGRVTVGF AISISSMACC
IYVSEIVRPH QRGTLVSLYE TGITVGILIS YAMNYFLSAV NDGWKYMFGL AIIPAAFQFI
VILFLPSKPH TLNFWEQDSD NGFIELEEAG ESGEFKPDTY DKQYTFLDLF RSKDNMRTRT
LLGLGLVLFQ QFTGQPNVLY YASTIFRSVG FQSNSSAVLA SVGLGVVKVA STLIAICFAD
KAGRRILLLA GCIVMTIAIS GIGIVSFMVE LDSHRDCGSI RSKNTSYGDS NASQLLGIIH
AGTPTINTKD NLAHQLAMVI QSPSLSNSAG SKHTASMFPN STVPPAGPDS NYAILNWITL
LSMMAFVSAF SIGFGPMTWL VLSEIYPADI RGRAFAFCNS FNWAANLLIT LTFLEVIGSI
GLGWTFLLYG GVGLLAIAFI YFFIPETKGQ SLEEIDQQLS SKRISKRRET SKGVRKRPST
GPPYQRVGKS NWT
