GTR10_XENTR
ID GTR10_XENTR Reviewed; 555 AA.
AC Q0P4G6;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Solute carrier family 2, facilitated glucose transporter member 10 {ECO:0000305};
DE AltName: Full=Glucose transporter type 10 {ECO:0000250|UniProtKB:O95528};
DE Short=GLUT-10 {ECO:0000250|UniProtKB:O95528};
GN Name=slc2a10 {ECO:0000250|UniProtKB:O95528};
GN Synonyms=glut10 {ECO:0000250|UniProtKB:O95528};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=N6; TISSUE=Skin;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Facilitative glucose transporter required for the development
CC of the cardiovascular system. {ECO:0000250|UniProtKB:O95528}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glucose(out) = D-glucose(in); Xref=Rhea:RHEA:60376,
CC ChEBI:CHEBI:4167; Evidence={ECO:0000250|UniProtKB:O95528};
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000250|UniProtKB:O95528}; Multi-pass membrane protein
CC {ECO:0000255}. Cytoplasm, perinuclear region
CC {ECO:0000250|UniProtKB:O95528}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
CC {ECO:0000305}.
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DR EMBL; BC122089; AAI22090.1; -; mRNA.
DR RefSeq; NP_001072926.1; NM_001079458.1.
DR RefSeq; XP_012808042.1; XM_012952588.2.
DR RefSeq; XP_012808043.1; XM_012952589.2.
DR RefSeq; XP_012808044.1; XM_012952590.2.
DR RefSeq; XP_012808046.1; XM_012952592.2.
DR RefSeq; XP_012808047.1; XM_012952593.2.
DR RefSeq; XP_012808049.1; XM_012952595.2.
DR AlphaFoldDB; Q0P4G6; -.
DR SMR; Q0P4G6; -.
DR STRING; 8364.ENSXETP00000032370; -.
DR PaxDb; Q0P4G6; -.
DR DNASU; 780388; -.
DR GeneID; 780388; -.
DR KEGG; xtr:780388; -.
DR CTD; 81031; -.
DR Xenbase; XB-GENE-950490; slc2a10.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_001265_30_5_1; -.
DR InParanoid; Q0P4G6; -.
DR OMA; GCIWLPE; -.
DR OrthoDB; 326501at2759; -.
DR PhylomeDB; Q0P4G6; -.
DR TreeFam; TF332408; -.
DR Reactome; R-XTR-189200; Cellular hexose transport.
DR Proteomes; UP000008143; Chromosome 10.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000003471; Expressed in ovary and 12 other tissues.
DR ExpressionAtlas; Q0P4G6; baseline.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005355; F:glucose transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015293; F:symporter activity; IBA:GO_Central.
DR GO; GO:0072359; P:circulatory system development; IBA:GO_Central.
DR GO; GO:1904659; P:glucose transmembrane transport; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 2.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 2.
PE 2: Evidence at transcript level;
KW Cytoplasm; Glycoprotein; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..555
FT /note="Solute carrier family 2, facilitated glucose
FT transporter member 10"
FT /id="PRO_0000270194"
FT TOPO_DOM 1..15
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 16..36
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 37..48
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 70..82
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 104..105
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 127..132
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 154..165
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 187..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..277
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 299..305
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..326
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 327..415
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 416..436
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 437..464
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 465..483
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 484..485
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 486..506
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 507..555
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 528..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 250..251
FT /ligand="D-glucose"
FT /ligand_id="ChEBI:CHEBI:4167"
FT /evidence="ECO:0000250|UniProtKB:P11169"
FT BINDING 441
FT /ligand="D-glucose"
FT /ligand_id="ChEBI:CHEBI:4167"
FT /evidence="ECO:0000250|UniProtKB:P11169"
FT CARBOHYD 161
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 274
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 344
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 351
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 400
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 413
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 555 AA; 60279 MW; 20657BBA7EF00F3A CRC64;
MGLSSPTLIL AATVSLLGGI VFGYELGIIS GALLVLKTVY QLTCFEQEAL VSAVLFGALL
ASLIGGIIID RWGRRTAILA SNLVVLAGSI ILIATSTFWW LIVGRVTIGF AISISSMACC
IYVSEIVRPH QRGMLVSLYE TGITVGILIS YAMNYFLSGV NESWKYMFGL AIVPAAFQFI
SILFLPSKPH KLNFWEQDTD DGFIELEETG EAGEFKPDTY DRQYTFLDLF RSKDNMRTRT
LLGLGLVLFQ QFTGQPNVLY YASTIFQSVG FQSNSSAVLA SVGLGVVKVA STLIAICFAD
KAGRRILLLA GCIVMTIAIT GIGIVSFTVK MDSHRDCGSV TGRNMSSGES NVSQLLGIVH
AETSTINTLD NSVHQLAMAI RSPSLANSAS SNHKDLISQN STVLPASPEL PSNYTILNWI
TLLSMMAFVS AFSIGFGPMT WIVLSEIYPA DIRGRAFAFC NSFNWAANLL ITLTFLDVIA
SIGLSWTFLL YGVVGLLAIA FIYFFIPETK GQSLEEIDKQ FSTKRILQKR ETSKGVGKRP
SSGPPYQRIG KASPS
