GTR11_HUMAN
ID GTR11_HUMAN Reviewed; 496 AA.
AC Q9BYW1; E9PH55; Q542Y4; Q6ICJ5; Q8WXF9; Q8WYM4;
DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 174.
DE RecName: Full=Solute carrier family 2, facilitated glucose transporter member 11 {ECO:0000305};
DE AltName: Full=Glucose transporter type 11 {ECO:0000303|PubMed:11741323};
DE Short=GLUT-11 {ECO:0000303|PubMed:11741323};
GN Name=SLC2A11 {ECO:0000303|PubMed:11741323, ECO:0000312|HGNC:HGNC:14239};
GN Synonyms=GLUT11 {ECO:0000303|PubMed:11741323};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Heart;
RA Doege H., Bocianski A., Scheepers A., Axer H., Eckel J., Joost H.-G.;
RT "Two novel members of the family of sugar transport facilitators: genomic
RT organization and predominant expression in lymphocytes (GLUT9) and muscle
RT (GLUT10).";
RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 2 AND 4), AND VARIANT GLN-232.
RX PubMed=11741323; DOI=10.1006/bbrc.2001.6101;
RA Sasaki T., Minoshima S., Shiohama A., Shintani A., Shimizu A., Asakawa S.,
RA Kawasaki K., Shimizu N.;
RT "Molecular cloning of a member of the facilitative glucose transporter gene
RT family GLUT11 (SLC2A11) and identification of transcription variants.";
RL Biochem. Biophys. Res. Commun. 289:1218-1224(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), ALTERNATIVE SPLICING, FUNCTION,
RP TRANSPORTER ACTIVITY, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=12175779; DOI=10.1016/s1096-7192(02)00018-5;
RA Wu X., Li W., Sharma V., Godzik A., Freeze H.H.;
RT "Cloning and characterization of glucose transporter 11, a novel sugar
RT transporter that is alternatively spliced in various tissues.";
RL Mol. Genet. Metab. 76:37-45(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA Beare D.M., Dunham I.;
RT "A genome annotation-driven approach to cloning the human ORFeome.";
RL Genome Biol. 5:R84.1-R84.11(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), AND VARIANT GLN-232.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-length
RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
RT libraries.";
RL DNA Res. 12:117-126(2005).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Facilitative glucose transporter.
CC {ECO:0000269|PubMed:12175779}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glucose(out) = D-glucose(in); Xref=Rhea:RHEA:60376,
CC ChEBI:CHEBI:4167; Evidence={ECO:0000269|PubMed:12175779};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12175779};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q9BYW1-1; Sequence=Displayed;
CC Name=2; Synonyms=GLUT11-s {ECO:0000303|PubMed:12175779};
CC IsoId=Q9BYW1-2; Sequence=VSP_006293, VSP_006294, VSP_006295;
CC Name=3;
CC IsoId=Q9BYW1-3; Sequence=VSP_006293;
CC Name=4; Synonyms=GLUT11-L {ECO:0000303|PubMed:12175779};
CC IsoId=Q9BYW1-4; Sequence=VSP_045650;
CC -!- TISSUE SPECIFICITY: Expressed in heart and skeletal muscle.
CC {ECO:0000269|PubMed:12175779}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
CC {ECO:0000305}.
CC -!- CAUTION: Has been described as GLUT10 in literature, but this gene name
CC has already been used for SLC2A10. {ECO:0000305|Ref.1}.
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DR EMBL; AJ271290; CAC29020.1; -; mRNA.
DR EMBL; AB049214; BAB68410.1; -; Genomic_DNA.
DR EMBL; AB067443; BAB83505.1; -; Genomic_DNA.
DR EMBL; AF443201; AAL39061.1; -; mRNA.
DR EMBL; CR456373; CAG30259.1; -; mRNA.
DR EMBL; AK075467; BAC11637.1; -; mRNA.
DR EMBL; AK314502; BAG37102.1; -; mRNA.
DR EMBL; AP000350; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471095; EAW59618.1; -; Genomic_DNA.
DR EMBL; BC100808; AAI00809.1; -; mRNA.
DR CCDS; CCDS13818.1; -. [Q9BYW1-4]
DR CCDS; CCDS33616.1; -. [Q9BYW1-3]
DR CCDS; CCDS46673.1; -. [Q9BYW1-1]
DR RefSeq; NP_001020109.1; NM_001024938.3. [Q9BYW1-1]
DR RefSeq; NP_001020110.1; NM_001024939.3. [Q9BYW1-3]
DR RefSeq; NP_110434.3; NM_030807.4. [Q9BYW1-4]
DR AlphaFoldDB; Q9BYW1; -.
DR SMR; Q9BYW1; -.
DR BioGRID; 122454; 1.
DR STRING; 9606.ENSP00000483038; -.
DR DrugBank; DB01914; D-glucose.
DR DrugBank; DB09341; Dextrose, unspecified form.
DR DrugBank; DB09502; Fludeoxyglucose (18F).
DR TCDB; 2.A.1.1.44; the major facilitator superfamily (mfs).
DR GlyGen; Q9BYW1; 1 site.
DR iPTMnet; Q9BYW1; -.
DR PhosphoSitePlus; Q9BYW1; -.
DR BioMuta; SLC2A11; -.
DR DMDM; 17366685; -.
DR MassIVE; Q9BYW1; -.
DR PaxDb; Q9BYW1; -.
DR PeptideAtlas; Q9BYW1; -.
DR PRIDE; Q9BYW1; -.
DR ProteomicsDB; 20459; -.
DR ProteomicsDB; 79727; -. [Q9BYW1-1]
DR ProteomicsDB; 79729; -. [Q9BYW1-3]
DR Antibodypedia; 45145; 28 antibodies from 12 providers.
DR DNASU; 66035; -.
DR Ensembl; ENST00000316185.9; ENSP00000326748.8; ENSG00000133460.20. [Q9BYW1-3]
DR Ensembl; ENST00000345044.10; ENSP00000342542.5; ENSG00000133460.20. [Q9BYW1-1]
DR Ensembl; ENST00000398356.6; ENSP00000381399.2; ENSG00000133460.20. [Q9BYW1-4]
DR Ensembl; ENST00000618502.4; ENSP00000482495.1; ENSG00000275744.4. [Q9BYW1-1]
DR Ensembl; ENST00000619254.4; ENSP00000480839.1; ENSG00000275744.4. [Q9BYW1-4]
DR Ensembl; ENST00000620942.4; ENSP00000483163.2; ENSG00000275744.4. [Q9BYW1-3]
DR GeneID; 66035; -.
DR KEGG; hsa:66035; -.
DR MANE-Select; ENST00000316185.9; ENSP00000326748.8; NM_001024939.4; NP_001020110.1. [Q9BYW1-3]
DR UCSC; uc002zym.6; human. [Q9BYW1-1]
DR CTD; 66035; -.
DR DisGeNET; 66035; -.
DR GeneCards; SLC2A11; -.
DR HGNC; HGNC:14239; SLC2A11.
DR HPA; ENSG00000133460; Low tissue specificity.
DR MIM; 610367; gene.
DR neXtProt; NX_Q9BYW1; -.
DR OpenTargets; ENSG00000133460; -.
DR PharmGKB; PA37861; -.
DR VEuPathDB; HostDB:ENSG00000133460; -.
DR eggNOG; KOG0569; Eukaryota.
DR GeneTree; ENSGT00940000161061; -.
DR HOGENOM; CLU_001265_30_11_1; -.
DR InParanoid; Q9BYW1; -.
DR OMA; WAIEWGI; -.
DR PhylomeDB; Q9BYW1; -.
DR TreeFam; TF313762; -.
DR PathwayCommons; Q9BYW1; -.
DR Reactome; R-HSA-189200; Cellular hexose transport.
DR SignaLink; Q9BYW1; -.
DR BioGRID-ORCS; 66035; 12 hits in 1054 CRISPR screens.
DR ChiTaRS; SLC2A11; human.
DR GeneWiki; SLC2A11; -.
DR GenomeRNAi; 66035; -.
DR Pharos; Q9BYW1; Tbio.
DR PRO; PR:Q9BYW1; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q9BYW1; protein.
DR Bgee; ENSG00000133460; Expressed in right hemisphere of cerebellum and 96 other tissues.
DR ExpressionAtlas; Q9BYW1; baseline and differential.
DR Genevisible; Q9BYW1; HS.
DR GO; GO:0030054; C:cell junction; IDA:HPA.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0005353; F:fructose transmembrane transporter activity; IDA:UniProtKB.
DR GO; GO:0005355; F:glucose transmembrane transporter activity; IDA:UniProtKB.
DR GO; GO:0015149; F:hexose transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0051119; F:sugar transmembrane transporter activity; TAS:Reactome.
DR GO; GO:0015755; P:fructose transmembrane transport; IDA:UniProtKB.
DR GO; GO:1904659; P:glucose transmembrane transport; IDA:UniProtKB.
DR GO; GO:0008645; P:hexose transmembrane transport; TAS:Reactome.
DR GO; GO:0015749; P:monosaccharide transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR045263; GLUT.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR PANTHER; PTHR23503; PTHR23503; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Glycoprotein; Membrane;
KW Reference proteome; Sugar transport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..496
FT /note="Solute carrier family 2, facilitated glucose
FT transporter member 11"
FT /id="PRO_0000050380"
FT TOPO_DOM 1..11
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 12..32
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 33..61
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..97
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..128
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..157
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 179..187
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..273
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 295..311
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 312..332
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 333..338
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 360..364
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 365..385
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 386..408
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 409..429
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 430..435
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 436..456
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 457..496
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 47
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..7
FT /note="MRALRRL -> MLHALLRSRM (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15461802"
FT /id="VSP_006293"
FT VAR_SEQ 1..7
FT /note="MRALRRL -> MEDELEPSLRPRTQ (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:12175779,
FT ECO:0000303|PubMed:14702039"
FT /id="VSP_045650"
FT VAR_SEQ 179..245
FT /note="RELLGGPQAWPLLLASCLVPGALQLASLPLLPESPRYLLIDCGDTEACLAAL
FT RRLRGSGDLAGELEE -> STTAATGLRGLGRGAGGAGGGARCLPGLPCPAPMGAVPAS
FT GPEETGDKPRGSGQCHGALRE (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_006294"
FT VAR_SEQ 246..496
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_006295"
FT VARIANT 60
FT /note="D -> N (in dbSNP:rs7292659)"
FT /id="VAR_046704"
FT VARIANT 232
FT /note="R -> Q (in dbSNP:rs9608213)"
FT /evidence="ECO:0000269|PubMed:11741323,
FT ECO:0000269|PubMed:14702039"
FT /id="VAR_046705"
FT VARIANT 301
FT /note="R -> Q (in dbSNP:rs36015336)"
FT /id="VAR_061881"
FT VARIANT 420
FT /note="I -> F (in dbSNP:rs34096096)"
FT /id="VAR_046706"
FT VARIANT 469
FT /note="K -> E (in dbSNP:rs60882514)"
FT /id="VAR_061882"
FT CONFLICT 229
FT /note="A -> E (in Ref. 3; AAL39061)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 496 AA; 53703 MW; 55FFEA82C7007D6D CRC64;
MRALRRLIQG RILLLTICAA GIGGTFQFGY NLSIINAPTL HIQEFTNETW QARTGEPLPD
HLVLLMWSLI VSLYPLGGLF GALLAGPLAI TLGRKKSLLV NNIFVVSAAI LFGFSRKAGS
FEMIMLGRLL VGVNAGVSMN IQPMYLGESA PKELRGAVAM SSAIFTALGI VMGQVVGLRE
LLGGPQAWPL LLASCLVPGA LQLASLPLLP ESPRYLLIDC GDTEACLAAL RRLRGSGDLA
GELEELEEER AACQGCRARR PWELFQHRAL RRQVTSLVVL GSAMELCGND SVYAYASSVF
RKAGVPEAKI QYAIIGTGSC ELLTAVVSCV VIERVGRRVL LIGGYSLMTC WGSIFTVALC
LQSSFPWTLY LAMACIFAFI LSFGIGPAGV TGILATELFD QMARPAACMV CGALMWIMLI
LVGLGFPFIM EALSHFLYVP FLGVCVCGAI YTGLFLPETK GKTFQEISKE LHRLNFPRRA
QGPTWRSLEV IQSTEL
