ID   GTR12_MACFA             Reviewed;         621 AA.
AC   Q9BE72;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Solute carrier family 2, facilitated glucose transporter member 12 {ECO:0000305};
DE   AltName: Full=Glucose transporter type 12 {ECO:0000250|UniProtKB:Q8TD20};
DE            Short=GLUT-12 {ECO:0000250|UniProtKB:Q8TD20};
GN   Name=SLC2A12 {ECO:0000250|UniProtKB:Q8TD20};
GN   Synonyms=GLUT12 {ECO:0000250|UniProtKB:Q8TD20};
GN   ORFNames=QflA-11110 {ECO:0000303|PubMed:11806829};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Frontal cortex;
RX   PubMed=11806829; DOI=10.1186/gb-2001-3-1-research0006;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Hirai M., Terao K.,
RA   Suzuki Y., Sugano S., Hashimoto K.;
RT   "Prediction of unidentified human genes on the basis of sequence similarity
RT   to novel cDNAs from cynomolgus monkey brain.";
RL   Genome Biol. 3:RESEARCH0006.1-RESEARCH0006.5(2002).
CC   -!- FUNCTION: Insulin-independent facilitative glucose transporter.
CC       {ECO:0000250|UniProtKB:Q8BFW9}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucose(out) = D-glucose(in); Xref=Rhea:RHEA:60376,
CC         ChEBI:CHEBI:4167; Evidence={ECO:0000250|UniProtKB:Q8BFW9};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BFW9};
CC       Multi-pass membrane protein {ECO:0000255}. Endomembrane system
CC       {ECO:0000250|UniProtKB:Q5J316}; Multi-pass membrane protein
CC       {ECO:0000255}. Cytoplasm, perinuclear region
CC       {ECO:0000250|UniProtKB:Q8TD20}. Note=Localizes primarily perinuclear
CC       region in the absence of insulin. {ECO:0000250|UniProtKB:Q8TD20}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC       transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB056798; BAB39322.1; -; mRNA.
DR   RefSeq; NP_001271639.1; NM_001284710.1.
DR   AlphaFoldDB; Q9BE72; -.
DR   SMR; Q9BE72; -.
DR   STRING; 9541.XP_005551945.1; -.
DR   GeneID; 102115752; -.
DR   CTD; 154091; -.
DR   eggNOG; KOG0254; Eukaryota.
DR   OrthoDB; 430696at2759; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR005828; MFS_sugar_transport-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR003663; Sugar/inositol_transpt.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   Pfam; PF00083; Sugar_tr; 2.
DR   PRINTS; PR00171; SUGRTRNSPORT.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Glycoprotein; Membrane; Reference proteome;
KW   Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..621
FT                   /note="Solute carrier family 2, facilitated glucose
FT                   transporter member 12"
FT                   /id="PRO_0000292015"
FT   TOPO_DOM        1..48
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        70..84
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        106..119
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        141
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        163..176
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        198..201
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        223..282
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        304..321
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        322..342
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        343..349
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        350..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        371..470
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        471..491
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        492..502
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        503..523
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        524..532
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        533..553
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        554..621
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        375
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        387
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        400
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        405
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   621 AA;  67486 MW;  9E9384A2320AC716 CRC64;
     MVPVENTEGP NLLNQKGTAV ETEGSYRASG SRHPPWARGC GMFTFLSSVT AAVSGLLVGY
     ELGIISGALL QIKTLLTLSC HEQEMVVSSL LIGALLASLT GGVLIDRYGR RTAIILSSCL
     LGLGSLVLIL SLSYTVLIVG RIAIGVSISL SSIATCVYIA EIAPQHRRGL LVSLNELMIV
     IGILSAYISN YAFANVFHGW KYMFGLVIPL GILQAIAMYF LPPSPRFLVM KGQEGAASKV
     LGRLRALSDA TEELTVIKSS LKDEYQYSFW DLFRSKDNMR TRIMIGLTLV FFVQITGQPN
     ILFYASTVLK SVGFQSNEAA SLASTGVGVV KVISTIPATL LVDHVGSKTF LCIGSSVMAA
     SLVTMGIVNL NIHMNFTNIC RSHNSINQSL DESVIYGPGN LSASNNTLRD HFKGIASHSR
     SSLMPLRNDV DKRGETTSAS LLNAVLSHTE YQIVTDPGDV PAFLKWLSLA SLLVYVAAFS
     IGLGPMPWLV LSEIFPGGIR GRAMALTSSM NWGINLLISL TFLTVTDLIG LPWVCFIYTI
     MSLASLLFVV MFIPETKGCS LEQISMELAK VNYVKNNICF MSHHQEELVP RQPQKRKPQE
     QLLECNKLCG RGQSRQLSPE N