GTR1_DROME
ID GTR1_DROME Reviewed; 1440 AA.
AC Q8IRI6; A8JNH6; A8JNH8; A8JNH9; M9PBH4; M9PBH5; M9PDK7; M9PDL1; M9PDS4;
AC M9PDS9; M9PE46; M9PGN5; M9PGP2; O77131; Q0E8K0; Q6NNA9; Q95TE8; Q9V409;
AC Q9W0L2;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 4.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Glucose transporter type 1;
DE Flags: Precursor;
GN Name=Glut1; ORFNames=CG43946;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAC36683.2}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), AND FUNCTION.
RC TISSUE=Embryo {ECO:0000269|PubMed:10479996};
RX PubMed=10479996; DOI=10.1111/j.1601-5223.1999.00095.x;
RA Andersson Escher S., Rasmuson-Lestander A.;
RT "The Drosophila glucose transporter gene: cDNA sequence, phylogenetic
RT comparisons, analysis of functional sites and secondary structures.";
RL Hereditas 130:95-103(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3] {ECO:0000305}
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000305, ECO:0000312|EMBL:AAL13347.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM S).
RC STRAIN=Berkeley {ECO:0000269|PubMed:12537569};
RC TISSUE=Head {ECO:0000269|PubMed:12537569};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM E).
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Carlson J., Chavez C., Frise E., George R., Pacleb J.,
RA Park S., Wan K., Yu C., Rubin G.M., Celniker S.;
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Facilitative glucose transporter.
CC {ECO:0000269|PubMed:10479996, ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=16;
CC Name=P;
CC IsoId=Q8IRI6-5; Sequence=Displayed;
CC Name=B {ECO:0000269|PubMed:10479996}; Synonyms=C
CC {ECO:0000303|PubMed:10731132};
CC IsoId=Q8IRI6-2; Sequence=VSP_054206, VSP_054208;
CC Name=D;
CC IsoId=Q8IRI6-3; Sequence=VSP_054204, VSP_054209;
CC Name=L;
CC IsoId=Q8IRI6-6; Sequence=VSP_054194, VSP_054202, VSP_054204,
CC VSP_054209;
CC Name=S;
CC IsoId=Q8IRI6-7; Sequence=VSP_054196, VSP_054201, VSP_054203;
CC Name=U;
CC IsoId=Q8IRI6-8; Sequence=VSP_054196, VSP_054198, VSP_054199;
CC Name=Q;
CC IsoId=Q8IRI6-9; Sequence=VSP_054210;
CC Name=M;
CC IsoId=Q8IRI6-10; Sequence=VSP_054205, VSP_054207;
CC Name=J;
CC IsoId=Q8IRI6-11; Sequence=VSP_054210, VSP_054211;
CC Name=O;
CC IsoId=Q8IRI6-12; Sequence=VSP_054197, VSP_054202, VSP_054204,
CC VSP_054209;
CC Name=R;
CC IsoId=Q8IRI6-13; Sequence=VSP_054195, VSP_054202, VSP_054204,
CC VSP_054209;
CC Name=W;
CC IsoId=Q8IRI6-14; Sequence=VSP_054196, VSP_054204, VSP_054209;
CC Name=X;
CC IsoId=Q8IRI6-15; Sequence=VSP_054196, VSP_054210, VSP_054211;
CC Name=V;
CC IsoId=Q8IRI6-16; Sequence=VSP_054196, VSP_054206, VSP_054208;
CC Name=E;
CC IsoId=Q8IRI6-17; Sequence=VSP_054202, VSP_054206, VSP_054208;
CC Name=T;
CC IsoId=Q8IRI6-18; Sequence=VSP_054193, VSP_054200;
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL13347.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF064703; AAC36683.2; -; mRNA.
DR EMBL; AE014296; AAF47434.2; -; Genomic_DNA.
DR EMBL; AE014296; AAN11454.5; -; Genomic_DNA.
DR EMBL; AE014296; ABW08432.1; -; Genomic_DNA.
DR EMBL; AE014296; ABW08433.1; -; Genomic_DNA.
DR EMBL; AE014296; ABW08434.2; -; Genomic_DNA.
DR EMBL; AE014296; ABW08435.2; -; Genomic_DNA.
DR EMBL; AE014296; AGB93925.1; -; Genomic_DNA.
DR EMBL; AE014296; AGB93926.1; -; Genomic_DNA.
DR EMBL; AE014296; AGB93927.1; -; Genomic_DNA.
DR EMBL; AE014296; AGB93928.1; -; Genomic_DNA.
DR EMBL; AE014296; AGB93929.1; -; Genomic_DNA.
DR EMBL; AE014296; AGB93930.1; -; Genomic_DNA.
DR EMBL; AE014296; AGB93931.1; -; Genomic_DNA.
DR EMBL; AE014296; AGB93932.1; -; Genomic_DNA.
DR EMBL; AE014296; AGB93933.1; -; Genomic_DNA.
DR EMBL; AY059441; AAL13347.1; ALT_FRAME; mRNA.
DR EMBL; BT011383; AAR96175.1; -; mRNA.
DR RefSeq; NP_001097467.1; NM_001103997.3. [Q8IRI6-3]
DR RefSeq; NP_001097468.1; NM_001103998.3. [Q8IRI6-17]
DR RefSeq; NP_001097469.2; NM_001103999.4. [Q8IRI6-6]
DR RefSeq; NP_001097470.2; NM_001104000.2. [Q8IRI6-9]
DR RefSeq; NP_001261230.1; NM_001274301.1. [Q8IRI6-10]
DR RefSeq; NP_001261231.1; NM_001274302.1. [Q8IRI6-11]
DR RefSeq; NP_001261232.1; NM_001274303.1. [Q8IRI6-12]
DR RefSeq; NP_001261233.1; NM_001274304.1. [Q8IRI6-13]
DR RefSeq; NP_001261234.1; NM_001274305.1. [Q8IRI6-18]
DR RefSeq; NP_001261235.1; NM_001274306.1. [Q8IRI6-8]
DR RefSeq; NP_001261236.1; NM_001274307.1. [Q8IRI6-16]
DR RefSeq; NP_001261237.1; NM_001274308.1. [Q8IRI6-14]
DR RefSeq; NP_001261238.1; NM_001274309.1. [Q8IRI6-15]
DR RefSeq; NP_001286896.1; NM_001299967.1. [Q8IRI6-11]
DR RefSeq; NP_523878.1; NM_079154.3. [Q8IRI6-2]
DR RefSeq; NP_612073.2; NM_138229.2. [Q8IRI6-5]
DR RefSeq; NP_728557.1; NM_167845.3. [Q8IRI6-2]
DR RefSeq; NP_728558.5; NM_167846.3. [Q8IRI6-7]
DR BioGRID; 63662; 2.
DR IntAct; Q8IRI6; 2.
DR STRING; 7227.FBpp0305687; -.
DR GlyGen; Q8IRI6; 2 sites.
DR PaxDb; Q8IRI6; -.
DR PRIDE; Q8IRI6; -.
DR DNASU; 38109; -.
DR EnsemblMetazoa; FBtr0333493; FBpp0305677; FBgn0264574. [Q8IRI6-10]
DR EnsemblMetazoa; FBtr0333494; FBpp0305678; FBgn0264574. [Q8IRI6-6]
DR EnsemblMetazoa; FBtr0333495; FBpp0305679; FBgn0264574. [Q8IRI6-11]
DR EnsemblMetazoa; FBtr0333496; FBpp0305680; FBgn0264574. [Q8IRI6-2]
DR EnsemblMetazoa; FBtr0333497; FBpp0305681; FBgn0264574. [Q8IRI6-2]
DR EnsemblMetazoa; FBtr0333498; FBpp0305682; FBgn0264574. [Q8IRI6-3]
DR EnsemblMetazoa; FBtr0333499; FBpp0305683; FBgn0264574. [Q8IRI6-17]
DR EnsemblMetazoa; FBtr0333500; FBpp0305684; FBgn0264574. [Q8IRI6-12]
DR EnsemblMetazoa; FBtr0333501; FBpp0305685; FBgn0264574. [Q8IRI6-5]
DR EnsemblMetazoa; FBtr0333502; FBpp0305686; FBgn0264574. [Q8IRI6-9]
DR EnsemblMetazoa; FBtr0333503; FBpp0305687; FBgn0264574. [Q8IRI6-13]
DR EnsemblMetazoa; FBtr0333504; FBpp0305688; FBgn0264574. [Q8IRI6-7]
DR EnsemblMetazoa; FBtr0333505; FBpp0305689; FBgn0264574. [Q8IRI6-18]
DR EnsemblMetazoa; FBtr0333506; FBpp0305690; FBgn0264574. [Q8IRI6-8]
DR EnsemblMetazoa; FBtr0333507; FBpp0305691; FBgn0264574. [Q8IRI6-16]
DR EnsemblMetazoa; FBtr0333508; FBpp0305692; FBgn0264574. [Q8IRI6-14]
DR EnsemblMetazoa; FBtr0333509; FBpp0305693; FBgn0264574. [Q8IRI6-15]
DR EnsemblMetazoa; FBtr0345690; FBpp0311739; FBgn0264574. [Q8IRI6-11]
DR GeneID; 38109; -.
DR KEGG; dme:Dmel_CG43946; -.
DR UCSC; CG1086-RD; d. melanogaster.
DR UCSC; CG1086-RE; d. melanogaster.
DR UCSC; CG1086-RF; d. melanogaster.
DR UCSC; CG13908-RA; d. melanogaster.
DR UCSC; CG13908-RB; d. melanogaster.
DR CTD; 38109; -.
DR FlyBase; FBgn0264574; Glut1.
DR VEuPathDB; VectorBase:FBgn0264574; -.
DR eggNOG; KOG0569; Eukaryota.
DR HOGENOM; CLU_004788_0_0_1; -.
DR InParanoid; Q8IRI6; -.
DR OMA; WIDFALF; -.
DR Reactome; R-DME-189200; Cellular hexose transport.
DR Reactome; R-DME-196836; Vitamin C (ascorbate) metabolism.
DR Reactome; R-DME-6798695; Neutrophil degranulation.
DR Reactome; R-DME-8981373; Intestinal hexose absorption.
DR BioGRID-ORCS; 38109; 0 hits in 3 CRISPR screens.
DR ChiTaRS; Glut1; fly.
DR GenomeRNAi; 38109; -.
DR PRO; PR:Q8IRI6; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0264574; Expressed in saliva-secreting gland and 30 other tissues.
DR ExpressionAtlas; Q8IRI6; baseline and differential.
DR Genevisible; Q8IRI6; DM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015149; F:hexose transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042593; P:glucose homeostasis; IMP:FlyBase.
DR GO; GO:0015749; P:monosaccharide transmembrane transport; IBA:GO_Central.
DR GO; GO:0090277; P:positive regulation of peptide hormone secretion; IMP:FlyBase.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR045263; GLUT.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR PANTHER; PTHR23503; PTHR23503; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome; Signal;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..1440
FT /note="Glucose transporter type 1"
FT /id="PRO_0000428674"
FT TOPO_DOM 24..67
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..95
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 117..127
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..162
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 184..186
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 208..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 311..331
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 332..339
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..360
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 361..372
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 373..393
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 394..405
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 406..426
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 427..429
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 430..450
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 451..534
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 535..555
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 556..1440
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 603..711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 724..808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 966..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1000..1083
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1167..1187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1301..1332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1351..1407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..626
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..709
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..746
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..789
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 790..808
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1016..1044
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1312..1332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1381..1403
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 162
FT /ligand="D-glucose"
FT /ligand_id="ChEBI:CHEBI:4167"
FT /evidence="ECO:0000250|UniProtKB:P11169"
FT BINDING 283..284
FT /ligand="D-glucose"
FT /ligand_id="ChEBI:CHEBI:4167"
FT /evidence="ECO:0000250|UniProtKB:P11169"
FT BINDING 289
FT /ligand="D-glucose"
FT /ligand_id="ChEBI:CHEBI:4167"
FT /evidence="ECO:0000250|UniProtKB:P11169"
FT BINDING 391
FT /ligand="D-glucose"
FT /ligand_id="ChEBI:CHEBI:4167"
FT /evidence="ECO:0000250|UniProtKB:P11169"
FT CARBOHYD 460
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 480
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..149
FT /note="MAFLCAPGLTFFLTYSIFSAVLGMLQFGYNTGVINAPEKNIENFMKDVYKDR
FT YGEDISEEFIQQLYSVAVSIFAIGGMLGGFSGGWMANRFGRKGGLLLNNVLGIAGACLM
FT GFTKVSHSYEMLFLGRFIIGVNCGLNTSLVPMYISEIA -> MATIGDLSMISPPTSSI
FT SNDQDPFGQLPPLPPPLRSTQVLQPLSVFPVSNLSEDSYDYVFGGRRKTPPTTTSTQLK
FT LTSPPVRLRPEDAYRGANINNGRFYRHSFSYAPKRQRHSSRDDRDRESRLRCHGEDEAT
FT LRQLLLEFAQVMFS (in isoform T)"
FT /evidence="ECO:0000305"
FT /id="VSP_054193"
FT VAR_SEQ 1..7
FT /note="MAFLCAP -> MSMNLSAKLDELQRGDRHLETTVALCEIRTQLQELTKSVES
FT CQSEVSEVKRDMVAIKHELDTVQQVKEEIEELREYVDRLEEHTHRRKLRLLEQ (in
FT isoform L)"
FT /evidence="ECO:0000305"
FT /id="VSP_054194"
FT VAR_SEQ 1..7
FT /note="MAFLCAP -> MATIGDLSMISPPTSSISNDQDPFGQLPPLPPPLRSTQVLQ
FT PLSVFPVSNLSEDSYDYVFGGRRKTPPTTTSTQLKLTSPPVRLRPEDAYRGANINNGRF
FT YRHSFSYAPKRQRHSSRDDRDRESRLRCHGEDEATLRQLLLDLQKQVSVMSMNLSAKLD
FT ELQRGDRHLETTVALCEIRTQLQELTKSVESCQSEVSEVKRDMVAIKHELDTVQQVKEE
FT IEELREYVDRLEEHTHRRKLRLLEQNQLPTTQSQTTTRPKNHPELPEHPSTQPHKTTDG
FT RNCHHDGQMQMLFGLAS (in isoform R)"
FT /evidence="ECO:0000305"
FT /id="VSP_054195"
FT VAR_SEQ 1..7
FT /note="MAFLCAP -> MATIGDLSMISPPTSSISNDQDPFGQLPPLPPPLRSTQVLQ
FT PLSVFPVSNLSEDSYDYVFGGRRKTPPTTTSTQLKLTSPPVRLRPEDAYRGANINNGRF
FT YRHSFSYAPKRQRHSSRDDRDRESRLRCHGEDEATLRQLLLDLQKQVSVMSMNLSAKLD
FT ELQRGDRHLETTVALCEIRTQLQELTKSVESCQSEVSEVKRDMVAIKHELDTVQQVKEE
FT IEELREYVDRLEEHTHRRKLRLLEQ (in isoform S, isoform U, isoform
FT W, isoform X and isoform V)"
FT /evidence="ECO:0000303|PubMed:12537569"
FT /id="VSP_054196"
FT VAR_SEQ 7
FT /note="P -> PVKRDMVAIKHELDTVQQVKEEIEELREYVDRLEEHTHRRKLRLLEQ
FT VCSLNYLPCC (in isoform O)"
FT /evidence="ECO:0000305"
FT /id="VSP_054197"
FT VAR_SEQ 8..72
FT /note="GLTFFLTYSIFSAVLGMLQFGYNTGVINAPEKNIENFMKDVYKDRYGEDISE
FT EFIQQLYSVAVSI -> NQLPTTQSQTTTRPKNHPELPEHPSTQPHKTTDGRNCHHDGQ
FT MQMLFGLASVSVHTQTNLSPITT (in isoform U)"
FT /evidence="ECO:0000305"
FT /id="VSP_054198"
FT VAR_SEQ 73..1440
FT /note="Missing (in isoform U)"
FT /evidence="ECO:0000305"
FT /id="VSP_054199"
FT VAR_SEQ 150..1440
FT /note="Missing (in isoform T)"
FT /evidence="ECO:0000305"
FT /id="VSP_054200"
FT VAR_SEQ 362..411
FT /note="EMIDWMSYLSVVATLGFVVFFAVGPGSIPWMITAELFSQGPRPSAMAIAV
FT -> ASIVVSRILESCSCSCRVMPANVNAKMPASLGLHLFVPRPFSDLHMTLKS (in
FT isoform S)"
FT /evidence="ECO:0000303|PubMed:12537569"
FT /id="VSP_054201"
FT VAR_SEQ 362
FT /note="E -> EFFGYVQE (in isoform L, isoform E, isoform O
FT and isoform R)"
FT /evidence="ECO:0000303|Ref.5"
FT /id="VSP_054202"
FT VAR_SEQ 412..1440
FT /note="Missing (in isoform S)"
FT /evidence="ECO:0000303|PubMed:12537569"
FT /id="VSP_054203"
FT VAR_SEQ 476..508
FT /note="RSMLNCTNSLEPQSMNSGIEHAALMVSEEKTQH -> SEDNANGNSVTTADF
FT ELSQNDGEEKGGVHAKAQ (in isoform D, isoform L, isoform O,
FT isoform R and isoform W)"
FT /evidence="ECO:0000305"
FT /id="VSP_054204"
FT VAR_SEQ 476..478
FT /note="RSM -> SRA (in isoform M)"
FT /evidence="ECO:0000305"
FT /id="VSP_054205"
FT VAR_SEQ 477..481
FT /note="SMLNC -> YVSLH (in isoform B, isoform E and isoform
FT V)"
FT /evidence="ECO:0000303|PubMed:10479996, ECO:0000303|Ref.5"
FT /id="VSP_054206"
FT VAR_SEQ 479..1440
FT /note="Missing (in isoform M)"
FT /evidence="ECO:0000305"
FT /id="VSP_054207"
FT VAR_SEQ 482..1440
FT /note="Missing (in isoform B, isoform E and isoform V)"
FT /evidence="ECO:0000303|PubMed:10479996, ECO:0000303|Ref.5"
FT /id="VSP_054208"
FT VAR_SEQ 509..1440
FT /note="Missing (in isoform D, isoform L, isoform O, isoform
FT R and isoform W)"
FT /evidence="ECO:0000305"
FT /id="VSP_054209"
FT VAR_SEQ 511..625
FT /note="LFGTTSFSLTVEGMGPYPLSDSTNLLGPGSSSYGPGGVLGLAGSGSGLGGQC
FT YTNYGTNLQTPQAARKCHYDEVDDYSFRRHSAHGRITQMKGKPLILGPTIKKDKKKERT
FT DWLT -> P (in isoform Q, isoform J and isoform X)"
FT /evidence="ECO:0000305"
FT /id="VSP_054210"
FT VAR_SEQ 663..1440
FT /note="Missing (in isoform J and isoform X)"
FT /evidence="ECO:0000305"
FT /id="VSP_054211"
SQ SEQUENCE 1440 AA; 158555 MW; 2F25FBC5E83AA97C CRC64;
MAFLCAPGLT FFLTYSIFSA VLGMLQFGYN TGVINAPEKN IENFMKDVYK DRYGEDISEE
FIQQLYSVAV SIFAIGGMLG GFSGGWMANR FGRKGGLLLN NVLGIAGACL MGFTKVSHSY
EMLFLGRFII GVNCGLNTSL VPMYISEIAP LNLRGGLGTV NQLAVTVGLL LSQVLGIEQI
LGTNEGWPIL LGLAICPAIL QLILLPVCPE SPRYLLITKQ WEEEARKALR RLRASGSVEE
DIEEMRAEER AQQSESHIST MELICSPTLR PPLIIGIVMQ LSQQFSGINA VFYYSTSLFM
SSGLTEESAK FATIGIGAIM VVMTLVSIPL MDRTGRRTLH LYGLGGMFIF SIFITISFLI
KEMIDWMSYL SVVATLGFVV FFAVGPGSIP WMITAELFSQ GPRPSAMAIA VLVNWMANFV
VGIGFPSMKT ALENYTFLPF SVFLAIFWIF TYKKVPETKN KTFEEILALF RHNNGRSMLN
CTNSLEPQSM NSGIEHAALM VSEEKTQHDS LFGTTSFSLT VEGMGPYPLS DSTNLLGPGS
SSYGPGGVLG LAGSGSGLGG QCYTNYGTNL QTPQAARKCH YDEVDDYSFR RHSAHGRITQ
MKGKPLILGP TIKKDKKKER TDWLTASERF LEGGRSTHQG RSAASAPHHP RQPPPVCPSS
GPXLRSASPP DSASVRSTSR AEEPHQPQQV HHQQQQVHHQ QQHQSRYATH EYVHCSYEKE
VVCDQANPSQ APPQQPAPPV QQHQQQPPPP LHHCQQRKHS HSPHHSRHTS PHSHHHHSHH
SRHSRRSRRQ GSGSLPGAHQ GSANHSVMRP SICTSRRHRS VTDISTTNVC QDPACSDREV
QEIMVRRTCC NTTATNSSSR TELAQCFAED LYGSSRRPSS CCTSSDYCYQ TDSTSLYGSR
SSLSRNNSIK SASALVRKHH RSQRSLLPEH RHPSYTSISL RGLNASRPNS QLGSLTSIFD
RAKNMAPEGS TLERQSSKGA LGSSELPEYA CSPSPIRWSF LADGRSPSEM EGAVGGGPER
EQEEEDKLDA WQVPEPEPEK KPCRKITTSS SVYDEGPSTS AAAARKRRGS KGSRGSKGSG
SYHCEFEDEA TTTVMFHQDA GEAYNNCCSN NYNYIQCNTY LDQDLQITSE DIHQYLSKGD
ATASDILNNS KNYPFQPSNA LEFQYKNNFQ QGQANANNNN TNTTNTASSD AAECFQNYRA
ISKETNLNQT STEQLSPTNI NLSTSSNNIN IVFSSSLERN ANEVKFINNR SGASGGSEMG
CEVGHHAGYL PYTYPSYDYT NMSGNSHFEK PLGIDELPKE FCGLEGAGGG GASTTSEHSS
SLPSPQPLTH HQQLHHFESF DAASEHNLLA AQPMSPGSPL SGSVNPAGDD FVQMHHYHHA
NSPHSQSHHS HAHTHTHGHH VHHLLNHPAY DLTDDQFRLG SALKRVRKRA RKYTDFLRKK
