ID   GTR1_LEIDO              Reviewed;         547 AA.
AC   Q01440;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Membrane transporter D1;
OS   Leishmania donovani.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5661;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1435876; DOI=10.1016/0166-6851(92)90126-5;
RA   Langford C.K., Ewbank S.A., Hanson S.S., Ullman B., Landfear S.M.;
RT   "Molecular characterization of two genes encoding members of the glucose
RT   transporter superfamily in the parasitic protozoan Leishmania donovani.";
RL   Mol. Biochem. Parasitol. 55:51-64(1992).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC       transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR   EMBL; M85072; AAA29230.1; -; Genomic_DNA.
DR   PIR; A48442; A48442.
DR   AlphaFoldDB; Q01440; -.
DR   SMR; Q01440; -.
DR   TCDB; 2.A.1.1.20; the major facilitator superfamily (mfs).
DR   VEuPathDB; TriTrypDB:LdBPK_240690.1; -.
DR   VEuPathDB; TriTrypDB:LdCL_240011900; -.
DR   VEuPathDB; TriTrypDB:LDHU3_24.0820; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR005828; MFS_sugar_transport-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR003663; Sugar/inositol_transpt.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   Pfam; PF00083; Sugar_tr; 1.
DR   PRINTS; PR00171; SUGRTRNSPORT.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00879; SP; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR   PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE   3: Inferred from homology;
KW   Membrane; Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..547
FT                   /note="Membrane transporter D1"
FT                   /id="PRO_0000050451"
FT   TOPO_DOM        1..2
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        3..25
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        26..43
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        65..78
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        100..101
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        123..136
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        158..164
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..185
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        186..245
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        246..266
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        267..276
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..297
FT                   /note="Helical; Name=8"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        298..308
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        309..329
FT                   /note="Helical; Name=9"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        330..339
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        340..360
FT                   /note="Helical; Name=10"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        361..385
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        386..406
FT                   /note="Helical; Name=11"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        407
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        408..428
FT                   /note="Helical; Name=12"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        429..547
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          449..468
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          510..547
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        515..533
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   547 AA;  58788 MW;  CA8EEF16EB0FF514 CRC64;
     MRASVMLCAA LGGFLFGYDT GVINAALFQM KDHFGFSEHS WQYALIVAIA IAGAFVGAFI
     SGFISAAFGR RPCIAVADAL FVIGSVLMGA APNVEVVLVS RVIVGLAIGI SSATIPVYLA
     EVTSPKHRGA TIVLNNLFLT GGQFVAAGFT AIMVVFTSKN IGWRVAIGIG ALPAVVQAFC
     LLFFLPESPR WLLSKGHADR AKAVADKFEV DLCEFQEGDE LPSVRIDYRP LMARDMRFRV
     VLSSGLQIIQ QFSGINTIMY YSSVILYDAG FRDAIMPVVL SIPLAFMNAL FTAVAIFTVD
     RFGRRRMLLI SVFGCLVLLV VIAIIGFFIG TRISYSVGGG LFLALLAVFL ALYAPGIGCI
     PWVIMGEIFP THLRTSAASV ATMANWGANV LVSQVFPILM GAIGVGGTFT IISGLMALGC
     IFVYFFAVET KGLTLEQIDN MFRKRAGLPP RFHEEGESGE SGAGYREDGD LGRLATEDVC
     DLSSLGNRVV SFAKAEDAFT EVAMPDRHAV SNKFEERATS SSSDPQSLEN QDEVRQAAIK
     AAPHEPK