ID   GTR2_LEIDO              Reviewed;         558 AA.
AC   Q01441;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Membrane transporter D2;
OS   Leishmania donovani.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5661;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1435876; DOI=10.1016/0166-6851(92)90126-5;
RA   Langford C.K., Ewbank S.A., Hanson S.S., Ullman B., Landfear S.M.;
RT   "Molecular characterization of two genes encoding members of the glucose
RT   transporter superfamily in the parasitic protozoan Leishmania donovani.";
RL   Mol. Biochem. Parasitol. 55:51-64(1992).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- DEVELOPMENTAL STAGE: Predominantly found in promastigotes.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC       transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR   EMBL; M85073; AAA29231.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q01441; -.
DR   SMR; Q01441; -.
DR   TCDB; 2.A.1.1.16; the major facilitator superfamily (mfs).
DR   VEuPathDB; TriTrypDB:LdBPK_330310.1; -.
DR   VEuPathDB; TriTrypDB:LdCL_330008000; -.
DR   VEuPathDB; TriTrypDB:LDHU3_33.0380; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR045263; GLUT.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR005828; MFS_sugar_transport-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR003663; Sugar/inositol_transpt.
DR   PANTHER; PTHR23503; PTHR23503; 1.
DR   Pfam; PF00083; Sugar_tr; 1.
DR   PRINTS; PR00171; SUGRTRNSPORT.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00879; SP; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..558
FT                   /note="Membrane transporter D2"
FT                   /id="PRO_0000050452"
FT   TOPO_DOM        1..38
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..59
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        60..152
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        174..179
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        201..204
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        226..241
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        263..281
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        282..302
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        303..335
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        336..356
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        357..373
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        374..394
FT                   /note="Helical; Name=8"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        395..402
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        403..423
FT                   /note="Helical; Name=9"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        424..441
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        442..463
FT                   /note="Helical; Name=10"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        464..478
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        479..499
FT                   /note="Helical; Name=11"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        500..512
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        513..533
FT                   /note="Helical; Name=12"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        534..558
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   558 AA;  60216 MW;  777E02FB623B92C8 CRC64;
     MTLKKRSSAP ELPTSLDEDE EEDSPQPLSN TPFFSMKNLI VATPIILTPL LYGYNLGFVG
     PYSTMYGYAS NCQLYSAKKS CETLTAAKCR WFNASTYVSN TTYGEVCGWA DRTTCFLKYS
     DEAGCLSDSA CKWSYSANTC GNQVGYSSIQ SGVFAGSLVI GSTMGALMGG YLTKRLDYCK
     SFLFIGLLSV IGNVLTHVAT GLFHYWVLFV ARIVLGFPLG WQSITSSHYT DKFAPANHAK
     TLGTLFQVSV STGIFVTSFF GLVLGNTIQY DAASNANTMG RMQGLVSVST LLSIFVVFLP
     LITKDGYSKS RRGDYEGENS EDASRKAAEE YTMTQMIGPI LNGVAMGCVT QLTGINANMN
     FAPTIMSNLG LQPLVGNIIV MAWNMLATFC VIPLSRRFSM RTLFLFCGFV GSLCCVFLGG
     IPVYPGVTKS DKAISGIAIT GIAIFIALYE MGVGPCFYVL AVDVFPESFR PIGSSITVGV
     MFIFNLIINI CYPIATEGIS GGPSGNPNKG QAVAFIFFGC IGVVACVIEY FFLQPWVEPE
     AKMTDDLDGA AVPEGKHD