ID   GTR2_SCHPO              Reviewed;         314 AA.
AC   O74544;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=GTP-binding protein gtr2;
GN   Name=gtr2; ORFNames=SPCC777.05;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: GTPase involved in activation of the TORC1 signaling pathway,
CC       which promotes growth and represses autophagy in nutrient-rich
CC       conditions (By similarity). Also required for TORC1 inactivation during
CC       nitrogen starvation (By similarity). {ECO:0000250|UniProtKB:A0A6A5PVF7,
CC       ECO:0000250|UniProtKB:P53290}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250|UniProtKB:P53290};
CC       Peripheral membrane protein {ECO:0000305}. Cytoplasm
CC       {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the GTR/RAG GTP-binding protein family.
CC       {ECO:0000305}.
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DR   EMBL; CU329672; CAA20709.1; -; Genomic_DNA.
DR   PIR; T11711; T11711.
DR   RefSeq; NP_588251.1; NM_001023241.2.
DR   AlphaFoldDB; O74544; -.
DR   SMR; O74544; -.
DR   BioGRID; 275660; 10.
DR   STRING; 4896.SPCC777.05.1; -.
DR   iPTMnet; O74544; -.
DR   MaxQB; O74544; -.
DR   PaxDb; O74544; -.
DR   PRIDE; O74544; -.
DR   EnsemblFungi; SPCC777.05.1; SPCC777.05.1:pep; SPCC777.05.
DR   GeneID; 2539088; -.
DR   KEGG; spo:SPCC777.05; -.
DR   PomBase; SPCC777.05; gtr2.
DR   VEuPathDB; FungiDB:SPCC777.05; -.
DR   eggNOG; KOG3887; Eukaryota.
DR   HOGENOM; CLU_047421_1_1_1; -.
DR   InParanoid; O74544; -.
DR   OMA; DTQRDIM; -.
DR   PhylomeDB; O74544; -.
DR   Reactome; R-SPO-165159; MTOR signalling.
DR   Reactome; R-SPO-9639288; Amino acids regulate mTORC1.
DR   PRO; PR:O74544; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; IDA:PomBase.
DR   GO; GO:1990131; C:Gtr1-Gtr2 GTPase complex; IGI:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0005525; F:GTP binding; ISM:PomBase.
DR   GO; GO:0003924; F:GTPase activity; ISO:PomBase.
DR   GO; GO:0043539; F:protein serine/threonine kinase activator activity; EXP:PomBase.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; IBA:GO_Central.
DR   GO; GO:0009267; P:cellular response to starvation; IBA:GO_Central.
DR   GO; GO:0110045; P:negative regulation of cell cycle switching, mitotic to meiotic cell cycle; EXP:PomBase.
DR   GO; GO:0032008; P:positive regulation of TOR signaling; IBA:GO_Central.
DR   GO; GO:1904263; P:positive regulation of TORC1 signaling; EXP:PomBase.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0010506; P:regulation of autophagy; IBA:GO_Central.
DR   CDD; cd11385; RagC_like; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR006762; Gtr1_RagA.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039400; RagC/D.
DR   PANTHER; PTHR11259; PTHR11259; 1.
DR   Pfam; PF04670; Gtr1_RagA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; GTP-binding; Membrane; Nucleotide-binding; Nucleus;
KW   Protein transport; Reference proteome; Transport; Vacuole.
FT   CHAIN           1..314
FT                   /note="GTP-binding protein gtr2"
FT                   /id="PRO_0000372338"
FT   BINDING         10..17
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         118..121
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P53290"
SQ   SEQUENCE   314 AA;  35592 MW;  59322BA97C4392B6 CRC64;
     MKPRKIILMG LRRSGKSSIQ KVVFYKMPPN ETLFLESTSK LTQDHISSFI DFSVWDFPGQ
     VDVFDAAFDF ESIFTQVGAL IFVIDAQDDY LDALARLHVT VARVVTINPN ICIEVFIHKV
     DGLSDEFKID TQRDIQQRTQ DELADIGLEN VPISFHLTSI FDHSIFEAFS RVIQKLIPQL
     PTLENLLNIF CSNSLVEKAY LFDVLSKIYV ATDSSPVDVQ SYEICSDFID VILDIGSIYG
     RSSQLKPGHS PEILDETSSV IRLSNDLVLF LREMNQYLAL ICIVRADNFE KSGLIEYNVQ
     CLQTAIQSIF SPRT