GTS1_ARATH
ID GTS1_ARATH Reviewed; 392 AA.
AC Q944S2; O82247;
DT 28-FEB-2018, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 156.
DE RecName: Full=WD repeat-containing protein GTS1 {ECO:0000305};
DE AltName: Full=Protein GIGANTUS 1 {ECO:0000303|PubMed:24467952};
GN Name=GTS1 {ECO:0000303|PubMed:24467952};
GN OrderedLocusNames=At2g47790 {ECO:0000312|Araport:AT2G47790};
GN ORFNames=F17A22.18 {ECO:0000312|EMBL:AEC10888.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:AAL11563.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=24467952; DOI=10.1186/1471-2229-14-37;
RA Gachomo E.W., Jimenez-Lopez J.C., Baptiste L.J., Kotchoni S.O.;
RT "GIGANTUS1 (GTS1), a member of Transducin/WD40 protein superfamily,
RT controls seed germination, growth and biomass accumulation through
RT ribosome-biogenesis protein interactions in Arabidopsis thaliana.";
RL BMC Plant Biol. 14:37-37(2014).
CC -!- FUNCTION: Involved in the control of plant growth development. Acts as
CC negative regulator of seed germination, cell division in meristematic
CC regions, plant growth and overall biomass accumulation. May function by
CC regulating ribosome activities and biogenesis in plant cells.
CC {ECO:0000269|PubMed:24467952}.
CC -!- TISSUE SPECIFICITY: Expressed in germinating seeds, rosettes leaves,
CC flowers and siliques. {ECO:0000269|PubMed:24467952}.
CC -!- DISRUPTION PHENOTYPE: Fast germination rate, fast growth rate,
CC increased biomass accumulation and early flowering.
CC {ECO:0000269|PubMed:24467952}.
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DR EMBL; AC005309; AAC63654.2; -; Genomic_DNA.
DR EMBL; CP002685; AEC10888.1; -; Genomic_DNA.
DR EMBL; AF424569; AAL11563.1; -; mRNA.
DR EMBL; BT000571; AAN18140.1; -; mRNA.
DR PIR; E84919; E84919.
DR RefSeq; NP_566111.1; NM_130346.4.
DR AlphaFoldDB; Q944S2; -.
DR SMR; Q944S2; -.
DR STRING; 3702.AT2G47790.1; -.
DR iPTMnet; Q944S2; -.
DR PaxDb; Q944S2; -.
DR PRIDE; Q944S2; -.
DR ProteomicsDB; 247235; -.
DR EnsemblPlants; AT2G47790.1; AT2G47790.1; AT2G47790.
DR GeneID; 819391; -.
DR Gramene; AT2G47790.1; AT2G47790.1; AT2G47790.
DR KEGG; ath:AT2G47790; -.
DR Araport; AT2G47790; -.
DR TAIR; locus:2043393; AT2G47790.
DR eggNOG; KOG1188; Eukaryota.
DR HOGENOM; CLU_037323_4_2_1; -.
DR InParanoid; Q944S2; -.
DR OMA; SDFNKYC; -.
DR OrthoDB; 1546666at2759; -.
DR PhylomeDB; Q944S2; -.
DR PRO; PR:Q944S2; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q944S2; baseline and differential.
DR GO; GO:0040008; P:regulation of growth; IMP:TAIR.
DR GO; GO:0010029; P:regulation of seed germination; IMP:TAIR.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR039328; WDR89.
DR PANTHER; PTHR22889; PTHR22889; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Growth regulation; Reference proteome; Repeat;
KW WD repeat.
FT CHAIN 1..392
FT /note="WD repeat-containing protein GTS1"
FT /id="PRO_0000443284"
FT REPEAT 81..124
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 128..167
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 171..211
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 323..368
FT /note="WD 4"
FT /evidence="ECO:0000255"
SQ SEQUENCE 392 AA; 43066 MW; 255C4578116DF17E CRC64;
MEEVSSEMEV EVQNRQLSDS SPAQNVKKFG LKNSIQTNFG SDYVFQIVPK IDWTAIAVSL
STNTVKLYSP VTGQYYGECK GHSDTVNQIA FSSDSAASPH VLHSCSSDGT IRSWDTRSFQ
QVSRIDTGND QEIFSFSYGG AADNLLAGGC KEQVLLWDWR NSKQVACLEE SHMDDVTQVH
FVPNKPNKLL SASVDGLICL FNTEGDINDD DHLESVINVG TSIGKIGFLG DGYKKLWCLT
HIETLSIWNW EDGSCEVNLE KARELASDSW TQDNVDYFVD CHCPGGEDLW VIGGTCAGTV
GYFPVNYKQP GSIGTAEAIL GGGHIDVVRS VLQMPGEYGG AAGLFGWTGG EDGRLCCWKS
DEDATEINRS WTSSELVVKP PRNRKKNRHS PY
