ID   GTSC1_HUMAN             Reviewed;         136 AA.
AC   Q86UQ5; J3KSW9;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-SEP-2014, sequence version 2.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Gilles de la Tourette syndrome chromosomal region candidate gene 1 protein;
GN   Name=GTSCR1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12682296; DOI=10.1073/pnas.0730775100;
RA   State M.W., Greally J.M., Cuker A., Bowers P.N., Henegariu O., Morgan T.,
RA   Gunel M., DiLuna M., King R.A., Nelson C., Donovan A., Anderson G.M.,
RA   Leckman J.F., Hawkins T., Pauls D.L., Lifton R.P., Ward D.C.;
RT   "Epigenetic abnormalities associated with a chromosome 18(q21-q22)
RT   inversion and a Gilles de la Tourette syndrome phenotype.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:4684-4689(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16177791; DOI=10.1038/nature03983;
RA   Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA   Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA   Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA   Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA   Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA   Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA   Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA   Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 18.";
RL   Nature 437:551-555(2005).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; AY262164; AAP13553.1; -; mRNA.
DR   EMBL; AC091646; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001265444.1; NM_001278515.1.
DR   AlphaFoldDB; Q86UQ5; -.
DR   IntAct; Q86UQ5; 1.
DR   BioMuta; HGNC:18406; -.
DR   PaxDb; Q86UQ5; -.
DR   PRIDE; Q86UQ5; -.
DR   GeneCards; GTSCR1; -.
DR   HGNC; HGNC:18406; GTSCR1.
DR   neXtProt; NX_Q86UQ5; -.
DR   InParanoid; Q86UQ5; -.
DR   OrthoDB; 1479340at2759; -.
DR   TreeFam; TF341508; -.
DR   PathwayCommons; Q86UQ5; -.
DR   BioGRID-ORCS; 220158; 4 hits in 511 CRISPR screens.
DR   ChiTaRS; GTSCR1; human.
DR   GenomeRNAi; 220158; -.
DR   Pharos; Q86UQ5; Tdark.
DR   PRO; PR:Q86UQ5; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q86UQ5; protein.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   5: Uncertain;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..136
FT                   /note="Gilles de la Tourette syndrome chromosomal region
FT                   candidate gene 1 protein"
FT                   /id="PRO_0000271344"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        19..35
FT                   /note="WVHSCGHEGHLRETAEI -> KVTYTILATASQVGSFA (in Ref. 1;
FT                   AAP13553)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   136 AA;  15623 MW;  62DC0F08C34340DA CRC64;
     MQSDIYHPGH SFPSWVLCWV HSCGHEGHLR ETAEIRKTHQ NGDLQIRGGR GRRESTEIFQ
     VASVTEGEES PPAICMEVFL FLWFIAPIYA CVCRIFKIQV RNTVKNSSTA SLAPSISTSE
     ERQIRIERHH YHLYGQ