ID   GTSF1_BOVIN             Reviewed;         167 AA.
AC   Q3SZU0;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Gametocyte-specific factor 1;
DE   AltName: Full=Protein FAM112B;
GN   Name=GTSF1; Synonyms=FAM112B;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for spermatogenesis and is involved in the
CC       suppression of retrotransposon transcription in male germ cells.
CC       {ECO:0000250|UniProtKB:Q9DAN6}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9DAN6}.
CC   -!- SIMILARITY: Belongs to the UPF0224 (FAM112) family. {ECO:0000305}.
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DR   EMBL; BC102713; AAI02714.1; -; mRNA.
DR   RefSeq; NP_001029445.1; NM_001034273.2.
DR   RefSeq; XP_005206160.1; XM_005206103.2.
DR   AlphaFoldDB; Q3SZU0; -.
DR   SMR; Q3SZU0; -.
DR   STRING; 9913.ENSBTAP00000044649; -.
DR   PaxDb; Q3SZU0; -.
DR   PRIDE; Q3SZU0; -.
DR   Ensembl; ENSBTAT00000047442; ENSBTAP00000044649; ENSBTAG00000018085.
DR   GeneID; 506864; -.
DR   KEGG; bta:506864; -.
DR   CTD; 121355; -.
DR   VEuPathDB; HostDB:ENSBTAG00000018085; -.
DR   VGNC; VGNC:29712; GTSF1.
DR   eggNOG; KOG4376; Eukaryota.
DR   GeneTree; ENSGT00940000156784; -.
DR   HOGENOM; CLU_108762_0_0_1; -.
DR   InParanoid; Q3SZU0; -.
DR   OrthoDB; 1359124at2759; -.
DR   TreeFam; TF323837; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000018085; Expressed in oocyte and 48 other tissues.
DR   ExpressionAtlas; Q3SZU0; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR007917; GTSF1_vertebrate.
DR   InterPro; IPR022776; TRM13/UPF0224_CHHC_Znf_dom.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   PANTHER; PTHR21402:SF9; PTHR21402:SF9; 1.
DR   Pfam; PF05253; zf-U11-48K; 2.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS51800; ZF_CHHC_U11_48K; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Differentiation; Metal-binding; Reference proteome; Repeat;
KW   Spermatogenesis; Zinc; Zinc-finger.
FT   CHAIN           1..167
FT                   /note="Gametocyte-specific factor 1"
FT                   /id="PRO_0000226547"
FT   ZN_FING         14..41
FT                   /note="CHHC U11-48K-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01141"
FT   ZN_FING         48..75
FT                   /note="CHHC U11-48K-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01141"
FT   BINDING         17
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01141"
FT   BINDING         23
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01141"
FT   BINDING         33
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01141"
FT   BINDING         37
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01141"
FT   BINDING         51
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01141"
FT   BINDING         57
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01141"
FT   BINDING         67
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01141"
FT   BINDING         71
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01141"
SQ   SEQUENCE   167 AA;  19146 MW;  4FB11C527CC4D81B CRC64;
     MEETYIDTLD PEKLLQCPYD KNHQIRACRF PYHLIKCRKN HPDVANKLAT CPFNARHQVP
     RAEISHHISS CDDKSCIEQD VVNQTRSLGQ ETMAESTWRC PPCDEDWDKD LWEQTSTPFV
     WGTANYCGNN SPASNIVMEH KSNLASGMRV PKSLPYVLPW KNNGNAQ