ID   GTSF1_MACFA             Reviewed;         167 AA.
AC   Q4R8M9;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Gametocyte-specific factor 1;
DE   AltName: Full=Protein FAM112B;
GN   Name=GTSF1; Synonyms=FAM112B; ORFNames=QtsA-12026;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for spermatogenesis and is involved in the
CC       suppression of retrotransposon transcription in male germ cells.
CC       {ECO:0000250|UniProtKB:Q9DAN6}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9DAN6}.
CC   -!- SIMILARITY: Belongs to the UPF0224 (FAM112) family. {ECO:0000305}.
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DR   EMBL; AB168422; BAE00543.1; -; mRNA.
DR   RefSeq; NP_001270250.1; NM_001283321.1.
DR   RefSeq; XP_005571147.1; XM_005571090.2.
DR   RefSeq; XP_015286141.1; XM_015430655.1.
DR   AlphaFoldDB; Q4R8M9; -.
DR   SMR; Q4R8M9; -.
DR   STRING; 9541.XP_005571145.1; -.
DR   Ensembl; ENSMFAT00000015082; ENSMFAP00000040812; ENSMFAG00000041178.
DR   GeneID; 101866532; -.
DR   KEGG; mcf:101866532; -.
DR   CTD; 121355; -.
DR   VEuPathDB; HostDB:ENSMFAG00000041178; -.
DR   eggNOG; KOG4376; Eukaryota.
DR   GeneTree; ENSGT00940000156784; -.
DR   OMA; LNEYTIC; -.
DR   Proteomes; UP000233100; Chromosome 11.
DR   Bgee; ENSMFAG00000041178; Expressed in multicellular organism and 6 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR007917; GTSF1_vertebrate.
DR   InterPro; IPR022776; TRM13/UPF0224_CHHC_Znf_dom.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   PANTHER; PTHR21402:SF9; PTHR21402:SF9; 1.
DR   Pfam; PF05253; zf-U11-48K; 2.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS51800; ZF_CHHC_U11_48K; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Differentiation; Metal-binding; Phosphoprotein;
KW   Reference proteome; Repeat; Spermatogenesis; Zinc; Zinc-finger.
FT   CHAIN           1..167
FT                   /note="Gametocyte-specific factor 1"
FT                   /id="PRO_0000226548"
FT   ZN_FING         14..41
FT                   /note="CHHC U11-48K-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01141"
FT   ZN_FING         48..75
FT                   /note="CHHC U11-48K-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01141"
FT   BINDING         17
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01141"
FT   BINDING         23
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01141"
FT   BINDING         33
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01141"
FT   BINDING         37
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01141"
FT   BINDING         51
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01141"
FT   BINDING         57
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01141"
FT   BINDING         67
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01141"
FT   BINDING         71
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01141"
FT   MOD_RES         8
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8WW33"
SQ   SEQUENCE   167 AA;  19266 MW;  00C39EF69263F495 CRC64;
     MEETYTDSLD PEKLLQCPYD KNHQIRACRF PYHLIKCRKN HPDVASKLAT CPFNARHQVP
     RAEISHHISS CDDRSCIEQD VVNQTRSLRQ ETLAESTWQC PPCDEDWDKD LWEQTSTPFV
     WGTTHYSDNN SPASNIVTEH KNNLASGMRV PKSLPYVLPW KNNGNAQ