ID   AMPR_CITKO              Reviewed;         285 AA.
AC   P52658;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=HTH-type transcriptional activator AmpR;
GN   Name=ampR;
OS   Citrobacter koseri (Citrobacter diversus).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Citrobacter.
OX   NCBI_TaxID=545;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ULA-27;
RX   PubMed=8064842; DOI=10.1099/00222615-41-3-209;
RA   Jones M.E., Avison M.B., Damdinsuren E., Macgowan A.P., Bennett P.M.;
RT   "Heterogeneity at the beta-lactamase structural gene ampC amongst
RT   Citrobacter spp. assessed by polymerase chain reaction analysis: potential
RT   for typing at a molecular level.";
RL   J. Med. Microbiol. 41:209-214(1994).
CC   -!- FUNCTION: This protein is a positive regulator of gene expression of
CC       beta-lactamase (AmpC).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X77656; CAA54736.1; -; Genomic_DNA.
DR   AlphaFoldDB; P52658; -.
DR   SMR; P52658; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..285
FT                   /note="HTH-type transcriptional activator AmpR"
FT                   /id="PRO_0000105585"
FT   DOMAIN          5..62
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        22..41
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   285 AA;  32186 MW;  44A870A05057989A CRC64;
     MRSNLPLNAL RAFEASARHL SFTRAALELC VTQAAVSQQV RILEDRLNRV LFKRLPRGLE
     MTDEAQALFA VLTDAFGQID TIFRQFEGGE YREVLTVAAV GTFAVGWLLP RIEQFRQAHP
     FVELRLRTNN NVVNLAAEGL DFAIRFGNGL WPATHNEMLF EAPLTVLCTP ETAQRLRRPA
     DLLQENLLRS YRVDEWDNWF AAAGVTAERI NGAVFDSSRL MVETVIHTGG AALVPAVMFA
     RELAAGQLVR PFDIEIQMGY WLTHLKSKPM TPAMEIFRDW IVKMA