ID   AMPR_ENTCL              Reviewed;         291 AA.
AC   P05051;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=HTH-type transcriptional activator AmpR;
GN   Name=ampR;
OS   Enterobacter cloacae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Enterobacter; Enterobacter cloacae complex.
OX   NCBI_TaxID=550;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3030737; DOI=10.1002/j.1460-2075.1986.tb04704.x;
RA   Honore N., Nicolas M.H., Cole S.T.;
RT   "Inducible cephalosporinase production in clinical isolates of Enterobacter
RT   cloacae is controlled by a regulatory gene that has been deleted from
RT   Escherichia coli.";
RL   EMBO J. 5:3709-3714(1986).
CC   -!- FUNCTION: This protein is a positive regulator of gene expression of
CC       cephalosporinase (AmpC).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; X04730; CAA28440.1; -; Genomic_DNA.
DR   PIR; A25686; A25686.
DR   RefSeq; WP_003855952.1; NZ_PEHU01000016.1.
DR   AlphaFoldDB; P05051; -.
DR   SMR; P05051; -.
DR   STRING; 1399774.JDWH01000001_gene2858; -.
DR   eggNOG; COG0583; Bacteria.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Transcription; Transcription regulation.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..291
FT                   /note="HTH-type transcriptional activator AmpR"
FT                   /id="PRO_0000105587"
FT   DOMAIN          6..63
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        23..42
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   291 AA;  32646 MW;  35441C10101CD732 CRC64;
     MTRSYLPLNS LRAFEAAARH LSFTHAAIEL NVTHSAISQH VKTLEQHLNC QLFVRVSRGL
     MLTTEGENLL PVLNDSFDRI AGMLDRFANH RAQEKLKIGV VGTFATGVLF SQLEDFRRGY
     PHIDLQLSTH NNRVDPAAEG LDYTIRYGGG AWHGTEAEFL CHAPLAPLCT PDIAASLHSP
     ADILRFTLLR SYRRDEWTAW MQAAGEHPPS PTHRVMVFDS SVTMLEAAQA GVGIAIAPVD
     MFTHLLASER IVQPFATQIE LGSYWLTRLQ SRAETPAMRE FSRWLVEKMK K