ID   AMPR_PROST              Reviewed;         292 AA.
AC   O69772;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=HTH-type transcriptional activator AmpR;
GN   Name=ampR;
OS   Providencia stuartii.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Providencia.
OX   NCBI_TaxID=588;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=VDG 96;
RA   Koeck J.L., Basmaciogullari S., Parzy D., Barnaud G., Teyssou R.,
RA   Buisson Y., Philippon A., Arlet G.J.;
RT   "Cloning and sequencing of ampC and ampR genes from Providencia stuartii.";
RL   Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is a positive regulator of gene expression of
CC       beta-lactamase (AmpC).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; Y17315; CAA76738.1; -; Genomic_DNA.
DR   RefSeq; WP_014657004.1; NZ_WLUK01000057.1.
DR   AlphaFoldDB; O69772; -.
DR   SMR; O69772; -.
DR   STRING; 588.BGK56_12155; -.
DR   OMA; TNNNRVD; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..292
FT                   /note="HTH-type transcriptional activator AmpR"
FT                   /id="PRO_0000105588"
FT   DOMAIN          9..66
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        26..45
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   292 AA;  32742 MW;  9B2CEFF667E112F0 CRC64;
     MSGNYRHRLP LNALRAFEAS ARHLSFTRAG LELNVTQAAV SQQVRLLEEQ LGLELFIRLP
     RGLALTDEGL ALLPVLSRSF DQIESLLQQF EDGHYHEVLS VSVVGTFAVG WLLPRLPAFA
     ALYPYIDLRI MTHNNVVNLA AEGVDFAIRF GEGLWPLAEN TALFSAAHTV LCSEKVANKL
     THPLDLKDHS LMRSYRKDEW EKWQIAAELE PWRVKGPIFD SSRLMVEAAL LTDGVALAPS
     CMFEHELSAG TLVQPFDISV TLGGYWLSRL KSRPTTPAMA IFRHWLLAEV QK