ID   AMPR_YEREN              Reviewed;         294 AA.
AC   P45461;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=HTH-type transcriptional activator AmpR;
GN   Name=ampR;
OS   Yersinia enterocolitica.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=630;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=IP97 / Serotype O:5B;
RX   PubMed=1510392; DOI=10.1128/aac.36.5.1049;
RA   Seoane A., Francia M.V., Garcia Lobo J.M.;
RT   "Nucleotide sequence of the ampC-ampR region from the chromosome of
RT   Yersinia enterocolitica.";
RL   Antimicrob. Agents Chemother. 36:1049-1052(1992).
CC   -!- FUNCTION: This protein is a positive regulator of gene expression of
CC       beta-lactamase (AmpC).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X63149; CAA44851.1; -; Genomic_DNA.
DR   PIR; A48899; A48899.
DR   AlphaFoldDB; P45461; -.
DR   SMR; P45461; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..294
FT                   /note="HTH-type transcriptional activator AmpR"
FT                   /id="PRO_0000105591"
FT   DOMAIN          6..63
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        23..42
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   294 AA;  32853 MW;  216D9861C5D8693C CRC64;
     MVRSYIPLNS LRAFEAAARQ LSFTKAAIEL NVTHAAISQQ VKALEQRLNC RLFIRISRGL
     VLTTEGENLL PILNDSFDRI ADTLDRFSTG IIREKVRVGV VGTFATGYLL SRLRDFQQHS
     PHVDILLSTH NNRVDVVAEG LDYAIRYGNG ALAWHESHFM YAPPLAQLCA PSISKRFTPP
     TDLQRFMLLG SYRAMNWSAW FAAAGGSVPS PSQQIMMFDS SVSMLEAAQA EIGIALAPPA
     MFMHLLRSER IIQPFSTTVS LGGYWLTRLQ SRTETPAMRD FALWLLSEMK SEGE