ID   AMRZ_PSEO1              Reviewed;         108 AA.
AC   G8Q5R9;
DT   13-NOV-2019, integrated into UniProtKB/Swiss-Prot.
DT   22-FEB-2012, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Transcription factor AmrZ {ECO:0000303|PubMed:24670089};
GN   Name=amrZ {ECO:0000303|PubMed:24670089}; ORFNames=PSF113_4470;
OS   Pseudomonas ogarae (strain DSM 112162 / CECT 30235 / F113).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=1114970;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 112162 / CECT 30235 / F113;
RX   PubMed=22328765; DOI=10.1128/jb.06601-11;
RA   Redondo-Nieto M., Barret M., Morrisey J.P., Germaine K.,
RA   Martinez-Granero F., Barahona E., Navazo A., Sanchez-Contreras M.,
RA   Moynihan J.A., Giddens S.R., Coppoolse E.R., Muriel C., Stiekema W.J.,
RA   Rainey P.B., Dowling D., O'Gara F., Martin M., Rivilla R.;
RT   "Genome Sequence of the Biocontrol Strain Pseudomonas fluorescens F113.";
RL   J. Bacteriol. 194:1273-1274(2012).
RN   [2]
RP   FUNCTION.
RX   PubMed=24670089; DOI=10.1186/1471-2164-15-237;
RA   Martinez-Granero F., Redondo-Nieto M., Vesga P., Martin M., Rivilla R.;
RT   "AmrZ is a global transcriptional regulator implicated in iron uptake and
RT   environmental adaption in P. fluorescens F113.";
RL   BMC Genomics 15:237-237(2014).
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=29386661; DOI=10.1038/s41598-018-20419-9;
RA   Muriel C., Arrebola E., Redondo-Nieto M., Martinez-Granero F., Jalvo B.,
RA   Pfeilmeier S., Blanco-Romero E., Baena I., Malone J.G., Rivilla R.,
RA   Martin M.;
RT   "AmrZ is a major determinant of c-di-GMP levels in Pseudomonas fluorescens
RT   F113.";
RL   Sci. Rep. 8:1979-1979(2018).
CC   -!- FUNCTION: Functions as both a transcriptional activator and repressor
CC       of multiple genes encoding virulence factors as well as genes involved
CC       in environmental adaptation. Represses genes involved in iron
CC       homeostasis (PubMed:24670089, PubMed:29386661). Modulates intracellular
CC       levels of c-di-GMP which in turn regulates swimming motility and
CC       biofilm formation (PubMed:29386661). {ECO:0000269|PubMed:24670089,
CC       ECO:0000269|PubMed:29386661}.
CC   -!- DISRUPTION PHENOTYPE: Deletion shows increased swimming motility,
CC       decreased biofilm formation and very limited ability for competitive
CC       colonization of rhizosphere. {ECO:0000269|PubMed:29386661}.
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DR   EMBL; CP003150; AEV64463.1; -; Genomic_DNA.
DR   RefSeq; WP_003204761.1; NC_016830.1.
DR   AlphaFoldDB; G8Q5R9; -.
DR   SMR; G8Q5R9; -.
DR   STRING; 1114970.PSF113_4470; -.
DR   EnsemblBacteria; AEV64463; AEV64463; PSF113_4470.
DR   GeneID; 57477576; -.
DR   KEGG; pfe:PSF113_4470; -.
DR   PATRIC; fig|1114970.3.peg.4557; -.
DR   eggNOG; ENOG5033BNF; Bacteria.
DR   HOGENOM; CLU_148670_1_0_6; -.
DR   OrthoDB; 2050366at2; -.
DR   Proteomes; UP000005437; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:CACAO.
DR   Gene3D; 1.10.1220.10; -; 1.
DR   InterPro; IPR005569; Arc_DNA-bd_dom.
DR   InterPro; IPR013321; Arc_rbn_hlx_hlx.
DR   InterPro; IPR010985; Ribbon_hlx_hlx.
DR   Pfam; PF03869; Arc; 1.
DR   SUPFAM; SSF47598; SSF47598; 1.
PE   4: Predicted;
KW   Activator; DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..108
FT                   /note="Transcription factor AmrZ"
FT                   /id="PRO_0000448533"
SQ   SEQUENCE   108 AA;  12387 MW;  B36DE54C5F6837A0 CRC64;
     MRPLKQAIYS SRTADKFVVR LPDGMRERIA EVARNHHRSM NSEIIARLEQ SLIQEGALGE
     ELSMRLDSPE LSLHERELLQ RFRQLSHRQQ NALVSLIAHD AEMAADAT