AMS2_SCHPO
ID AMS2_SCHPO Reviewed; 697 AA.
AC Q9URT4; Q9P7Z1;
DT 16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2003, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=CENP-A multicopy suppressor protein 2;
GN Name=ams2; ORFNames=SPCC290.04, SPCC4F11.01;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION, SUBUNIT, AND SUBCELLULAR LOCATION.
RX PubMed=12535531; DOI=10.1016/s1097-2765(03)00011-x;
RA Chen E.S., Saitoh S., Yanagida M., Takahashi K.;
RT "A cell cycle-regulated GATA factor promotes centromeric localization of
RT CENP-A in fission yeast.";
RL Mol. Cell 11:175-187(2003).
CC -!- FUNCTION: Required for proper chromosome segregation via regulation of
CC CENP-A localization to the centromere. {ECO:0000269|PubMed:12535531}.
CC -!- SUBUNIT: Interacts with CENP-A. {ECO:0000269|PubMed:12535531}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12535531}.
CC Chromosome, centromere {ECO:0000269|PubMed:12535531}.
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DR EMBL; CU329672; CAB61504.1; -; Genomic_DNA.
DR PIR; T41352; T41352.
DR RefSeq; NP_588400.2; NM_001023391.2.
DR AlphaFoldDB; Q9URT4; -.
DR BioGRID; 275812; 339.
DR STRING; 4896.SPCC290.04.1; -.
DR iPTMnet; Q9URT4; -.
DR PaxDb; Q9URT4; -.
DR PRIDE; Q9URT4; -.
DR EnsemblFungi; SPCC290.04.1; SPCC290.04.1:pep; SPCC290.04.
DR GeneID; 2539242; -.
DR KEGG; spo:SPCC290.04; -.
DR PomBase; SPCC290.04; ams2.
DR VEuPathDB; FungiDB:SPCC290.04; -.
DR eggNOG; ENOG502QUGJ; Eukaryota.
DR HOGENOM; CLU_404984_0_0_1; -.
DR InParanoid; Q9URT4; -.
DR OMA; PWRSELF; -.
DR PRO; PR:Q9URT4; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0000785; C:chromatin; IDA:PomBase.
DR GO; GO:0034506; C:chromosome, centromeric core domain; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0019237; F:centromeric DNA binding; IDA:PomBase.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IMP:PomBase.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; EXP:PomBase.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0034080; P:CENP-A containing chromatin assembly; IMP:PomBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:PomBase.
DR GO; GO:0071459; P:protein localization to chromosome, centromeric region; IMP:PomBase.
DR CDD; cd00202; ZnF_GATA; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR042403; Spt21/Ams2.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR39147; PTHR39147; 3.
DR Pfam; PF00320; GATA; 1.
DR SMART; SM00401; ZnF_GATA; 1.
DR PROSITE; PS00344; GATA_ZN_FINGER_1; 1.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
PE 1: Evidence at protein level;
KW Centromere; Chromosome; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..697
FT /note="CENP-A multicopy suppressor protein 2"
FT /id="PRO_0000083474"
FT ZN_FING 351..378
FT /note="GATA-type; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT REGION 443..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 697 AA; 78160 MW; 37E68D8232C1C069 CRC64;
MMEKSLNTVT SLPLRVIYCI DRASAIRCLA KSQHAVPIQV LKEVEPKKVI CQVDIQHVIQ
TVCRCSPELS CKSQGDFSVY FLDHTEPDEL FVGLGYWSSL LLSPTLNAGT SNSDTVWVNG
FIVEFGIQRS IEIKLRFQSL QNSFEVGTPE THTSSKFLSS TLPPSLIFDP SSSEKSDSIS
GSLFDTNYTC PVNINGLSKQ KSVRELKSPS RPSALAETNV EELELDSLFH ASNDISCSAT
SFSEPYILDH QAALDHPATD PVCSASSTTV NSAVSTKKRR RESSTISPES AYVAAQLQNP
SEREQVHEFI KEQVRIARGR IEKKFTNVRG KNRIEEQLTL SLQEGKIPPY CQNCGTIKTA
NWRNATYMNI TLMLCNACGI YWTSRRSMRP RNLWSTYKAF ETEKPLENDA FAQLELAVYK
LSQQRKLSIS IFRELENAGR HSPLNRLTSL DSTHSAPDPN HISKPSVVNQ QKSRGGPRTA
KLKNDLRRIQ SSPIVAPTPD TSFREPLSEI GSNDSWLVLP NSLSANIQND VLRKTDFMCT
DKENVAFPLK TTTKPMPKVN KEETEPTLPV CDSEKENDDL ECYFRTPPKP TTLQKQQQSP
SPWRSELFLS DPDQNVLTPR HKPKFDLSKA LSSVAKSNNI ENSPQLPERY DFSLELGLNS
QLDNEERRDI PLMTDLVMPS SPPMVPADRH LSVENTC
