ID   GUC2A_DIDVI             Reviewed;          15 AA.
AC   P55936;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   11-DEC-2019, entry version 49.
DE   RecName: Full=Guanylin;
DE   AltName: Full=Guanylate cyclase activator 2A;
GN   Name=GUCA2A; Synonyms=GUCA2;
OS   Didelphis virginiana (North American opossum) (Didelphis marsupialis
OS   virginiana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Didelphimorphia; Didelphidae; Didelphis.
OX   NCBI_TaxID=9267;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Urine;
RX   PubMed=7902563; DOI=10.1073/pnas.90.22.10464;
RA   Hamra F.K., Forte L.R., Eber S.L., Pidhorodeckyj N.V., Krause W.J.,
RA   Freeman R.H., Chin D.T., Tompkins J.A., Fok K.F., Smith C.E., Duffin K.L.,
RA   Siegel N.R., Currie M.G.;
RT   "Uroguanylin: structure and activity of a second endogenous peptide that
RT   stimulates intestinal guanylate cyclase.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:10464-10468(1993).
CC   -!- FUNCTION: Endogenous activator of intestinal guanylate cyclase. It
CC       stimulates this enzyme through the same receptor binding region as the
CC       heat-stable enterotoxins.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the guanylin family. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Secreted.
FT   PEPTIDE         1..15
FT                   /note="Guanylin"
FT                   /id="PRO_0000043961"
FT   DISULFID        4..12
FT                   /evidence="ECO:0000250"
FT   DISULFID        7..15
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   15 AA;  1487 MW;  C96D059D7282F712 CRC64;
     SHTCEICAFA ACAGC