GUC2A_MOUSE
ID GUC2A_MOUSE Reviewed; 116 AA.
AC P33680;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Guanylin;
DE AltName: Full=Guanylate cyclase activator 2A;
DE Flags: Precursor;
GN Name=Guca2a; Synonyms=Guca2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Small intestine;
RX PubMed=1409606; DOI=10.1073/pnas.89.19.9089;
RA de Sauvage F.J., Keshav S., Kuang W.J., Gillett N., Henzel W.,
RA Goeddel D.V.;
RT "Precursor structure, expression, and tissue distribution of human
RT guanylin.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:9089-9093(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RA Kato J., Wiegand R.C., Currie M.G.;
RT "Cloning of precursor cDNA for guanylin: an endogenous activator of
RT intestinal guanylate cyclase.";
RL Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=129/Sv;
RX PubMed=7713512; DOI=10.1006/geno.1994.1670;
RA Sciaky D., Kosiba J.L., Cohen M.B.;
RT "Genomic sequence of the murine guanylin gene.";
RL Genomics 24:583-587(1994).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Small intestine;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Endogenous activator of intestinal guanylate cyclase. It
CC stimulates this enzyme through the same receptor binding region as the
CC heat-stable enterotoxins.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Localized in both crypts and villi in the small
CC intestine and to superficial epithelial cells in the colon.
CC -!- SIMILARITY: Belongs to the guanylin family. {ECO:0000305}.
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DR EMBL; M95175; AAA37758.1; -; mRNA.
DR EMBL; L05516; AAA37715.1; -; mRNA.
DR EMBL; U60528; AAB05758.1; -; Genomic_DNA.
DR EMBL; AK075814; BAC35981.1; -; mRNA.
DR EMBL; BC012640; AAH12640.1; -; mRNA.
DR CCDS; CCDS18586.1; -.
DR PIR; A55643; B46279.
DR RefSeq; NP_032216.1; NM_008190.1.
DR AlphaFoldDB; P33680; -.
DR SMR; P33680; -.
DR STRING; 10090.ENSMUSP00000024015; -.
DR PaxDb; P33680; -.
DR PeptideAtlas; P33680; -.
DR PRIDE; P33680; -.
DR ProteomicsDB; 271064; -.
DR Antibodypedia; 2733; 180 antibodies from 21 providers.
DR DNASU; 14915; -.
DR Ensembl; ENSMUST00000024015; ENSMUSP00000024015; ENSMUSG00000023247.
DR GeneID; 14915; -.
DR KEGG; mmu:14915; -.
DR UCSC; uc008umv.1; mouse.
DR CTD; 2980; -.
DR MGI; MGI:102738; Guca2a.
DR VEuPathDB; HostDB:ENSMUSG00000023247; -.
DR eggNOG; ENOG502S7QR; Eukaryota.
DR GeneTree; ENSGT00940000154436; -.
DR HOGENOM; CLU_166952_0_0_1; -.
DR InParanoid; P33680; -.
DR OMA; PELCEIC; -.
DR OrthoDB; 1552271at2759; -.
DR PhylomeDB; P33680; -.
DR TreeFam; TF330731; -.
DR Reactome; R-MMU-8935690; Digestion.
DR BioGRID-ORCS; 14915; 0 hits in 71 CRISPR screens.
DR PRO; PR:P33680; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; P33680; protein.
DR Bgee; ENSMUSG00000023247; Expressed in right colon and 57 other tissues.
DR Genevisible; P33680; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030250; F:guanylate cyclase activator activity; ISO:MGI.
DR Gene3D; 3.90.1450.10; -; 1.
DR InterPro; IPR000879; Guanylin.
DR InterPro; IPR036382; Guanylin_sf.
DR PANTHER; PTHR11318; PTHR11318; 1.
DR Pfam; PF02058; Guanylin; 1.
DR PIRSF; PIRSF001849; Guanylin; 1.
DR PRINTS; PR00774; GUANYLIN.
DR SUPFAM; SSF89890; SSF89890; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT PROPEP 24..101
FT /id="PRO_0000013137"
FT PEPTIDE 102..116
FT /note="Guanylin"
FT /id="PRO_0000013138"
FT DISULFID 69..83
FT /evidence="ECO:0000250"
FT DISULFID 105..113
FT /evidence="ECO:0000250"
FT DISULFID 108..116
FT /evidence="ECO:0000250"
SQ SEQUENCE 116 AA; 12467 MW; 272E0D87C20869C7 CRC64;
MNACVLSVLC LLGALAVLVE GVTVQDGDLS FPLESVKKLK GLREVQEPRL VSHKKFAPRL
LQPVAPQLCS SHSALPEALR PVCEKPNAEE ILQRLEAIAQ DPNTCEICAY AACTGC
