ID   GUC2A_NOTAL             Reviewed;         115 AA.
AC   Q8R5G9;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Guanylin;
DE   AltName: Full=Guanylate cyclase activator 2A;
DE   Flags: Precursor;
GN   Name=GUCA2A;
OS   Notomys alexis (Spinifex hopping mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Notomys.
OX   NCBI_TaxID=184396;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Donald J.A., Bartolo R.C.;
RT   "Cloning and expression of guanylin and uroguanylin in the Spinifex hopping
RT   mouse, Notomys alexis.";
RL   Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Endogenous activator of intestinal guanylate cyclase. It
CC       stimulates this enzyme through the same receptor binding region as the
CC       heat-stable enterotoxins (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the guanylin family. {ECO:0000305}.
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DR   EMBL; AF469495; AAL77416.1; -; mRNA.
DR   AlphaFoldDB; Q8R5G9; -.
DR   SMR; Q8R5G9; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030250; F:guanylate cyclase activator activity; IEA:InterPro.
DR   Gene3D; 3.90.1450.10; -; 1.
DR   InterPro; IPR000879; Guanylin.
DR   InterPro; IPR036382; Guanylin_sf.
DR   PANTHER; PTHR11318; PTHR11318; 1.
DR   Pfam; PF02058; Guanylin; 1.
DR   PIRSF; PIRSF001849; Guanylin; 1.
DR   PRINTS; PR00774; GUANYLIN.
DR   SUPFAM; SSF89890; SSF89890; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..100
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000256704"
FT   PEPTIDE         101..115
FT                   /note="Guanylin"
FT                   /id="PRO_0000256705"
FT   DISULFID        69..82
FT                   /evidence="ECO:0000250"
FT   DISULFID        104..112
FT                   /evidence="ECO:0000250"
FT   DISULFID        107..115
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   115 AA;  12435 MW;  9645BE48795FB277 CRC64;
     MNACVLSVLC LLGAVAVLVE GVTVQDGDLS FPLESVKQLK DLREVQEPRL ASHKKFAPRL
     LKPVAPQLCS QSAFPEALRP LCEKPNAEEI LQRLEAIAQD PNTCEICAYA ACTGC