ID   GUC2A_PIG               Reviewed;         109 AA.
AC   P79897;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Guanylin;
DE   AltName: Full=Guanylate cyclase activator 2A;
DE   Flags: Precursor;
GN   Name=GUCA2A; Synonyms=GUCA2;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Jejunum;
RX   PubMed=10334930; DOI=10.1006/bbrc.1999.0719;
RA   Maegert H.-J., Hill O., Zucht H.-D., Martin S., Meyer M., Forssmann W.-G.,
RA   Adermann K.;
RT   "Porcine guanylin and uroguanylin: cDNA sequences, deduced amino acid
RT   sequences, and biological activity of the chemically synthesized
RT   peptides.";
RL   Biochem. Biophys. Res. Commun. 259:141-148(1999).
CC   -!- FUNCTION: Endogenous activator of intestinal guanylate cyclase. It
CC       stimulates this enzyme through the same receptor binding region as the
CC       heat-stable enterotoxins.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the guanylin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z73607; CAA97974.1; -; mRNA.
DR   RefSeq; NP_001153746.1; NM_001160274.1.
DR   RefSeq; XP_003360909.1; XM_003360861.2.
DR   AlphaFoldDB; P79897; -.
DR   SMR; P79897; -.
DR   STRING; 9823.ENSSSCP00000004290; -.
DR   PaxDb; P79897; -.
DR   PeptideAtlas; P79897; -.
DR   GeneID; 100301560; -.
DR   KEGG; ssc:100301560; -.
DR   CTD; 2980; -.
DR   eggNOG; ENOG502S7QR; Eukaryota.
DR   HOGENOM; CLU_166952_0_0_1; -.
DR   InParanoid; P79897; -.
DR   OMA; PELCEIC; -.
DR   OrthoDB; 1552271at2759; -.
DR   TreeFam; TF330731; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   Genevisible; P79897; SS.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030250; F:guanylate cyclase activator activity; IBA:GO_Central.
DR   Gene3D; 3.90.1450.10; -; 1.
DR   InterPro; IPR000879; Guanylin.
DR   InterPro; IPR036382; Guanylin_sf.
DR   PANTHER; PTHR11318; PTHR11318; 1.
DR   Pfam; PF02058; Guanylin; 1.
DR   PIRSF; PIRSF001849; Guanylin; 1.
DR   PRINTS; PR00774; GUANYLIN.
DR   SUPFAM; SSF89890; SSF89890; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..94
FT                   /id="PRO_0000013139"
FT   PEPTIDE         95..109
FT                   /note="Guanylin"
FT                   /id="PRO_0000013140"
FT   DISULFID        63..76
FT                   /evidence="ECO:0000250"
FT   DISULFID        98..106
FT                   /evidence="ECO:0000250"
FT   DISULFID        101..109
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   109 AA;  11938 MW;  6368BD1FB0B07A74 CRC64;
     MNTFLFPTLC LLGVWAALAG GVTVKDGEFS FSLESVKKLK DLQELQKPRN PRNLDGPIIP
     VLCNSPKFPE ELKPICQKPN AEEILERLET IAQDPSTCEI CAYAACAGC