ID   GUC2B_CAVPO             Reviewed;         111 AA.
AC   P70107;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Guanylate cyclase activator 2B;
DE   Contains:
DE     RecName: Full=Uroguanylin;
DE              Short=UGN;
DE   Flags: Precursor;
GN   Name=GUCA2B;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Stomach;
RA   Kruhoeffer M., Meyer M.F., Schlatter E., Kaempf U., Cetin Y.,
RA   Forssmann W.-G.;
RL   Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Endogenous activator of intestinal guanylate cyclase. It
CC       stimulates this enzyme through the same receptor binding region as the
CC       heat-stable enterotoxins. May be a potent physiological regulator of
CC       intestinal fluid and electrolyte transport. May be an
CC       autocrine/paracrine regulator of intestinal salt and water transport.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the guanylin family. {ECO:0000305}.
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DR   EMBL; Z74738; CAA98994.1; -; mRNA.
DR   RefSeq; NP_001166429.1; NM_001172958.1.
DR   AlphaFoldDB; P70107; -.
DR   SMR; P70107; -.
DR   STRING; 10141.ENSCPOP00000006119; -.
DR   GeneID; 100135535; -.
DR   KEGG; cpoc:100135535; -.
DR   CTD; 2981; -.
DR   eggNOG; ENOG502S7QR; Eukaryota.
DR   HOGENOM; CLU_166952_1_0_1; -.
DR   InParanoid; P70107; -.
DR   OrthoDB; 1566411at2759; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030250; F:guanylate cyclase activator activity; IEA:InterPro.
DR   Gene3D; 3.90.1450.10; -; 1.
DR   InterPro; IPR000879; Guanylin.
DR   InterPro; IPR036382; Guanylin_sf.
DR   PANTHER; PTHR11318; PTHR11318; 1.
DR   Pfam; PF02058; Guanylin; 1.
DR   PIRSF; PIRSF001849; Guanylin; 1.
DR   PRINTS; PR00774; GUANYLIN.
DR   SUPFAM; SSF89890; SSF89890; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   PROPEP          27..96
FT                   /id="PRO_0000013143"
FT   PEPTIDE         97..111
FT                   /note="Uroguanylin"
FT                   /id="PRO_0000013144"
FT   DISULFID        67..80
FT                   /evidence="ECO:0000250"
FT   DISULFID        100..108
FT                   /evidence="ECO:0000250"
FT   DISULFID        103..111
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   111 AA;  12125 MW;  7C3366A721FE0411 CRC64;
     MGSRTLLGHL SVLAVVLLLL LQGTQSVDIK YQGYQVQLES VKKLKALEEQ WVSSPRLQAQ
     DPQPAVCHHP ALPLDLQPIC TSQEAASILQ ALRTMDNDEC ELCVNIACTG C