ID   GUC2B_MOUSE             Reviewed;         106 AA.
AC   O09051;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2001, sequence version 2.
DT   03-AUG-2022, entry version 146.
DE   RecName: Full=Guanylate cyclase activator 2B;
DE   Contains:
DE     RecName: Full=Uroguanylin;
DE              Short=UGN;
DE   Flags: Precursor;
GN   Name=Guca2b;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=9287995; DOI=10.1016/s0016-5085(97)70197-5;
RA   Whitaker T.L., Witte D.P., Scott M.C., Cohen M.B.;
RT   "Uroguanylin and guanylin: distinct but overlapping patterns of messenger
RT   RNA expression in mouse intestine.";
RL   Gastroenterology 113:1000-1006(1997).
RN   [2]
RP   SEQUENCE REVISION TO 17.
RA   Sanford L.P., Cohen M.B.;
RL   Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Kidney;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Endogenous activator of intestinal guanylate cyclase. It
CC       stimulates this enzyme through the same receptor binding region as the
CC       heat-stable enterotoxins. May be a potent physiological regulator of
CC       intestinal fluid and electrolyte transport. May be an
CC       autocrine/paracrine regulator of intestinal salt and water transport
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Localized predominantly in intestinal villi and the
CC       corticomedullary junction of the kidney.
CC   -!- SIMILARITY: Belongs to the guanylin family. {ECO:0000305}.
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DR   EMBL; U95182; AAB82750.2; -; Genomic_DNA.
DR   EMBL; U90727; AAB53314.1; -; mRNA.
DR   CCDS; CCDS18587.1; -.
DR   RefSeq; NP_032217.2; NM_008191.2.
DR   AlphaFoldDB; O09051; -.
DR   SMR; O09051; -.
DR   STRING; 10090.ENSMUSP00000043203; -.
DR   PaxDb; O09051; -.
DR   PeptideAtlas; O09051; -.
DR   PRIDE; O09051; -.
DR   ProteomicsDB; 269846; -.
DR   Antibodypedia; 18083; 195 antibodies from 25 providers.
DR   DNASU; 14916; -.
DR   Ensembl; ENSMUST00000044426; ENSMUSP00000043203; ENSMUSG00000032978.
DR   GeneID; 14916; -.
DR   KEGG; mmu:14916; -.
DR   UCSC; uc012dkg.1; mouse.
DR   CTD; 2981; -.
DR   MGI; MGI:1270851; Guca2b.
DR   VEuPathDB; HostDB:ENSMUSG00000032978; -.
DR   eggNOG; ENOG502S7QR; Eukaryota.
DR   GeneTree; ENSGT00940000154436; -.
DR   HOGENOM; CLU_166952_1_0_1; -.
DR   InParanoid; O09051; -.
DR   OMA; CANPSCF; -.
DR   OrthoDB; 1566411at2759; -.
DR   TreeFam; TF330731; -.
DR   Reactome; R-MMU-8935690; Digestion.
DR   BioGRID-ORCS; 14916; 1 hit in 71 CRISPR screens.
DR   PRO; PR:O09051; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; O09051; protein.
DR   Bgee; ENSMUSG00000032978; Expressed in small intestine Peyer's patch and 53 other tissues.
DR   ExpressionAtlas; O09051; baseline and differential.
DR   Genevisible; O09051; MM.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0001750; C:photoreceptor outer segment; IDA:MGI.
DR   GO; GO:0030250; F:guanylate cyclase activator activity; IBA:GO_Central.
DR   GO; GO:0060612; P:adipose tissue development; IMP:MGI.
DR   GO; GO:0007589; P:body fluid secretion; IMP:MGI.
DR   GO; GO:0019934; P:cGMP-mediated signaling; ISO:MGI.
DR   GO; GO:0097009; P:energy homeostasis; IMP:MGI.
DR   GO; GO:0042593; P:glucose homeostasis; IMP:MGI.
DR   GO; GO:0035264; P:multicellular organism growth; IMP:MGI.
DR   GO; GO:0045776; P:negative regulation of blood pressure; IMP:MGI.
DR   GO; GO:0002023; P:reduction of food intake in response to dietary excess; IMP:MGI.
DR   GO; GO:0070294; P:renal sodium ion absorption; IMP:MGI.
DR   GO; GO:0009749; P:response to glucose; IMP:MGI.
DR   Gene3D; 3.90.1450.10; -; 1.
DR   InterPro; IPR000879; Guanylin.
DR   InterPro; IPR036382; Guanylin_sf.
DR   PANTHER; PTHR11318; PTHR11318; 1.
DR   Pfam; PF02058; Guanylin; 1.
DR   PIRSF; PIRSF001849; Guanylin; 1.
DR   PRINTS; PR00774; GUANYLIN.
DR   SUPFAM; SSF89890; SSF89890; 1.
PE   1: Evidence at protein level;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..91
FT                   /id="PRO_0000013150"
FT   PEPTIDE         92..106
FT                   /note="Uroguanylin"
FT                   /id="PRO_0000013151"
FT   DISULFID        62..75
FT                   /evidence="ECO:0000250"
FT   DISULFID        95..103
FT                   /evidence="ECO:0000250"
FT   DISULFID        98..106
FT                   /evidence="ECO:0000250"
FT   CONFLICT        17
FT                   /note="Q -> R (in Ref. 1; AAB53314)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   106 AA;  11628 MW;  30FF1CCE9D293DA8 CRC64;
     MSRSQLWAAV VLLLLLQSAQ GVYIKYHGFQ VQLESVKKLN ELEEKEMSNP QPRRSGLLPA
     VCHNPALPLD LQPVCASQEA ASTFKALRTI ATDECELCIN VACTGC