ID   GUC2B_PIG               Reviewed;         113 AA.
AC   O13009;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Guanylate cyclase activator 2B;
DE   Contains:
DE     RecName: Full=Uroguanylin;
DE              Short=UGN;
DE   Flags: Precursor;
GN   Name=GUCA2B;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Jejunum;
RX   PubMed=10334930; DOI=10.1006/bbrc.1999.0719;
RA   Maegert H.-J., Hill O., Zucht H.-D., Martin S., Meyer M., Forssmann W.-G.,
RA   Adermann K.;
RT   "Porcine guanylin and uroguanylin: cDNA sequences, deduced amino acid
RT   sequences, and biological activity of the chemically synthesized
RT   peptides.";
RL   Biochem. Biophys. Res. Commun. 259:141-148(1999).
CC   -!- FUNCTION: Endogenous activator of intestinal guanylate cyclase. It
CC       stimulates this enzyme through the same receptor binding region as the
CC       heat-stable enterotoxins. May be a potent physiological regulator of
CC       intestinal fluid and electrolyte transport. May be an
CC       autocrine/paracrine regulator of intestinal salt and water transport
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the guanylin family. {ECO:0000305}.
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DR   EMBL; Z83746; CAB06042.1; -; mRNA.
DR   RefSeq; NP_001153747.1; NM_001160275.1.
DR   AlphaFoldDB; O13009; -.
DR   SMR; O13009; -.
DR   STRING; 9823.ENSSSCP00000004292; -.
DR   PaxDb; O13009; -.
DR   Ensembl; ENSSSCT00000004392; ENSSSCP00000004292; ENSSSCG00000003970.
DR   GeneID; 100301561; -.
DR   KEGG; ssc:100301561; -.
DR   CTD; 2981; -.
DR   VGNC; VGNC:88748; GUCA2B.
DR   eggNOG; ENOG502S7QR; Eukaryota.
DR   GeneTree; ENSGT00940000154436; -.
DR   HOGENOM; CLU_216147_0_0_1; -.
DR   InParanoid; O13009; -.
DR   OMA; CANPSCF; -.
DR   OrthoDB; 1566411at2759; -.
DR   Proteomes; UP000008227; Chromosome 6.
DR   Proteomes; UP000314985; Unplaced.
DR   Bgee; ENSSSCG00000003970; Expressed in colon and 14 other tissues.
DR   Genevisible; O13009; SS.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030250; F:guanylate cyclase activator activity; IBA:GO_Central.
DR   Gene3D; 3.90.1450.10; -; 1.
DR   InterPro; IPR000879; Guanylin.
DR   InterPro; IPR036382; Guanylin_sf.
DR   PANTHER; PTHR11318; PTHR11318; 1.
DR   Pfam; PF02058; Guanylin; 1.
DR   PIRSF; PIRSF001849; Guanylin; 1.
DR   PRINTS; PR00774; GUANYLIN.
DR   SUPFAM; SSF89890; SSF89890; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   PROPEP          28..97
FT                   /id="PRO_0000013152"
FT   PEPTIDE         98..113
FT                   /note="Uroguanylin"
FT                   /id="PRO_0000013153"
FT   DISULFID        68..81
FT                   /evidence="ECO:0000250"
FT   DISULFID        101..109
FT                   /evidence="ECO:0000250"
FT   DISULFID        104..112
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   113 AA;  12044 MW;  8160573287BAB642 CRC64;
     MASRAAAGLL LCGVALVFLV LLQGTQSVYI QYQGFRVQLK SVKKLSDLEG QWAPSPRLQA
     QSPQPSVCHH SALPPDLQPI CQSEEAASIF QALRTIAGDD CELCVNVACT GCS