ID   GUC2B_RAT               Reviewed;         106 AA.
AC   P70668;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Guanylate cyclase activator 2B;
DE   Contains:
DE     RecName: Full=Uroguanylin;
DE              Short=UGN;
DE   Flags: Precursor;
GN   Name=Guca2b;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 92-106.
RC   STRAIN=Sprague-Dawley;
RX   PubMed=9094754; DOI=10.1016/s0167-0115(96)02103-9;
RA   Li Z., Perkins A.G., Peters M.F., Campa M.J., Goy M.F.;
RT   "Purification, cDNA sequence, and tissue distribution of rat uroguanylin.";
RL   Regul. Pept. 68:45-56(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8977100; DOI=10.1016/s0014-5793(96)01235-5;
RA   Miyazato M., Nakazato M., Matsukura S., Kangawa K., Matsuo H.;
RT   "Uroguanylin gene expression in the alimentary tract and extra-
RT   gastrointestinal tissues.";
RL   FEBS Lett. 398:170-174(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Small intestine;
RX   PubMed=9176203; DOI=10.1152/ajpgi.1997.272.5.g972;
RA   Blanchard R.K., Cousins R.J.;
RT   "Upregulation of rat intestinal uroguanylin mRNA by dietary zinc
RT   restriction.";
RL   Am. J. Physiol. 272:G972-G978(1997).
CC   -!- FUNCTION: Endogenous activator of intestinal guanylate cyclase. It
CC       stimulates this enzyme through the same receptor binding region as the
CC       heat-stable enterotoxins. May be a potent physiological regulator of
CC       intestinal fluid and electrolyte transport. May be an
CC       autocrine/paracrine regulator of intestinal salt and water transport.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed not only in the gastrointestinal tract
CC       but also in the lung, pancreas and kidney.
CC   -!- SIMILARITY: Belongs to the guanylin family. {ECO:0000305}.
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DR   EMBL; U73898; AAB18331.1; -; mRNA.
DR   EMBL; U41322; AAB18760.1; -; mRNA.
DR   EMBL; U75186; AAB61209.1; -; mRNA.
DR   RefSeq; NP_071620.1; NM_022284.2.
DR   AlphaFoldDB; P70668; -.
DR   SMR; P70668; -.
DR   STRING; 10116.ENSRNOP00000012062; -.
DR   PaxDb; P70668; -.
DR   Ensembl; ENSRNOT00000012062; ENSRNOP00000012062; ENSRNOG00000008979.
DR   GeneID; 64055; -.
DR   KEGG; rno:64055; -.
DR   CTD; 2981; -.
DR   RGD; 620044; Guca2b.
DR   eggNOG; ENOG502S7QR; Eukaryota.
DR   GeneTree; ENSGT00940000154436; -.
DR   HOGENOM; CLU_166952_1_0_1; -.
DR   InParanoid; P70668; -.
DR   OMA; CANPSCF; -.
DR   OrthoDB; 1566411at2759; -.
DR   PhylomeDB; P70668; -.
DR   TreeFam; TF330731; -.
DR   Reactome; R-RNO-8935690; Digestion.
DR   PRO; PR:P70668; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000008979; Expressed in jejunum and 14 other tissues.
DR   Genevisible; P70668; RN.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0001750; C:photoreceptor outer segment; ISO:RGD.
DR   GO; GO:0030250; F:guanylate cyclase activator activity; IBA:GO_Central.
DR   GO; GO:0060612; P:adipose tissue development; ISO:RGD.
DR   GO; GO:0007589; P:body fluid secretion; ISO:RGD.
DR   GO; GO:0019934; P:cGMP-mediated signaling; IDA:RGD.
DR   GO; GO:0097009; P:energy homeostasis; ISO:RGD.
DR   GO; GO:0042593; P:glucose homeostasis; ISO:RGD.
DR   GO; GO:0035264; P:multicellular organism growth; ISO:RGD.
DR   GO; GO:0045776; P:negative regulation of blood pressure; ISO:RGD.
DR   GO; GO:0002023; P:reduction of food intake in response to dietary excess; ISO:RGD.
DR   GO; GO:0070294; P:renal sodium ion absorption; ISO:RGD.
DR   GO; GO:0009749; P:response to glucose; ISO:RGD.
DR   GO; GO:0030104; P:water homeostasis; NAS:RGD.
DR   Gene3D; 3.90.1450.10; -; 1.
DR   InterPro; IPR000879; Guanylin.
DR   InterPro; IPR036382; Guanylin_sf.
DR   PANTHER; PTHR11318; PTHR11318; 1.
DR   Pfam; PF02058; Guanylin; 1.
DR   PIRSF; PIRSF001849; Guanylin; 1.
DR   PRINTS; PR00774; GUANYLIN.
DR   SUPFAM; SSF89890; SSF89890; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..91
FT                   /evidence="ECO:0000269|PubMed:9094754"
FT                   /id="PRO_0000013154"
FT   PEPTIDE         92..106
FT                   /note="Uroguanylin"
FT                   /id="PRO_0000013155"
FT   DISULFID        62..75
FT                   /evidence="ECO:0000250"
FT   DISULFID        95..103
FT                   /evidence="ECO:0000250"
FT   DISULFID        98..106
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   106 AA;  11573 MW;  9FB5F88A9B1DD077 CRC64;
     MSGSQLWAAV LLLLVLQSAQ GVYIKYHGFQ VQLESVKKLN ELEEKQMSDP QQQKSGLLPD
     VCYNPALPLD LQPVCASQEA ASTFKALRTI ATDECELCIN VACTGC