GUCD1_HUMAN
ID GUCD1_HUMAN Reviewed; 240 AA.
AC Q96NT3; B5MCB8; B5MCL7; Q96Q79; Q9BU32;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Protein GUCD1;
DE AltName: Full=Guanylyl cyclase domain-containing protein 1;
DE AltName: Full=Protein LLN4;
GN Name=GUCD1; Synonyms=C22orf13, LLN4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 11-240 (ISOFORM 1).
RC TISSUE=Placenta, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 15-239 (ISOFORM 2).
RA Shimizu N., Minosima S., Kawasaki K., Sasaki T.;
RT "Molecular cloning of a novel gene.";
RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- INTERACTION:
CC Q96NT3; O43186: CRX; NbExp=3; IntAct=EBI-8293751, EBI-748171;
CC Q96NT3; P32929: CTH; NbExp=3; IntAct=EBI-8293751, EBI-749763;
CC Q96NT3; Q6A162: KRT40; NbExp=3; IntAct=EBI-8293751, EBI-10171697;
CC Q96NT3; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-8293751, EBI-10172290;
CC Q96NT3; Q96IV0: NGLY1; NbExp=4; IntAct=EBI-8293751, EBI-6165879;
CC Q96NT3; P15884: TCF4; NbExp=3; IntAct=EBI-8293751, EBI-533224;
CC Q96NT3-2; O43184-4: ADAM12; NbExp=3; IntAct=EBI-11978177, EBI-12006944;
CC Q96NT3-2; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-11978177, EBI-10173507;
CC Q96NT3-2; Q9Y6H3: ATP23; NbExp=3; IntAct=EBI-11978177, EBI-12811889;
CC Q96NT3-2; Q9BUH8: BEGAIN; NbExp=3; IntAct=EBI-11978177, EBI-742722;
CC Q96NT3-2; Q494R4-2: CCDC153; NbExp=3; IntAct=EBI-11978177, EBI-11974185;
CC Q96NT3-2; Q8N684-3: CPSF7; NbExp=3; IntAct=EBI-11978177, EBI-11523759;
CC Q96NT3-2; P78358: CTAG1B; NbExp=3; IntAct=EBI-11978177, EBI-1188472;
CC Q96NT3-2; P32929: CTH; NbExp=3; IntAct=EBI-11978177, EBI-749763;
CC Q96NT3-2; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11978177, EBI-3867333;
CC Q96NT3-2; A0A0C3SFZ9: FCHO1; NbExp=3; IntAct=EBI-11978177, EBI-11977403;
CC Q96NT3-2; Q13643: FHL3; NbExp=3; IntAct=EBI-11978177, EBI-741101;
CC Q96NT3-2; Q9BTY2: FUCA2; NbExp=3; IntAct=EBI-11978177, EBI-9050116;
CC Q96NT3-2; Q9UBX0: HESX1; NbExp=3; IntAct=EBI-11978177, EBI-8470369;
CC Q96NT3-2; P49639: HOXA1; NbExp=5; IntAct=EBI-11978177, EBI-740785;
CC Q96NT3-2; Q9UBY9: HSPB7; NbExp=3; IntAct=EBI-11978177, EBI-739361;
CC Q96NT3-2; Q02535: ID3; NbExp=3; IntAct=EBI-11978177, EBI-1387094;
CC Q96NT3-2; Q86U28: ISCA2; NbExp=3; IntAct=EBI-11978177, EBI-10258659;
CC Q96NT3-2; Q9H079: KATNBL1; NbExp=3; IntAct=EBI-11978177, EBI-715394;
CC Q96NT3-2; Q5T749: KPRP; NbExp=3; IntAct=EBI-11978177, EBI-10981970;
CC Q96NT3-2; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-11978177, EBI-11959885;
CC Q96NT3-2; Q9BYS1: KRTAP1-5; NbExp=3; IntAct=EBI-11978177, EBI-11741292;
CC Q96NT3-2; P60410: KRTAP10-8; NbExp=5; IntAct=EBI-11978177, EBI-10171774;
CC Q96NT3-2; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-11978177, EBI-10172052;
CC Q96NT3-2; Q3SY46: KRTAP13-3; NbExp=5; IntAct=EBI-11978177, EBI-10241252;
CC Q96NT3-2; Q3LI72: KRTAP19-5; NbExp=3; IntAct=EBI-11978177, EBI-1048945;
CC Q96NT3-2; Q3LI70: KRTAP19-6; NbExp=3; IntAct=EBI-11978177, EBI-12805508;
CC Q96NT3-2; Q9BYR7: KRTAP3-2; NbExp=3; IntAct=EBI-11978177, EBI-751260;
CC Q96NT3-2; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-11978177, EBI-3957694;
CC Q96NT3-2; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-11978177, EBI-10172511;
CC Q96NT3-2; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-11978177, EBI-10250562;
CC Q96NT3-2; Q6L8G8: KRTAP5-7; NbExp=3; IntAct=EBI-11978177, EBI-11987425;
CC Q96NT3-2; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-11978177, EBI-1044640;
CC Q96NT3-2; Q9BYQ0: KRTAP9-8; NbExp=3; IntAct=EBI-11978177, EBI-11958364;
CC Q96NT3-2; Q14847-2: LASP1; NbExp=3; IntAct=EBI-11978177, EBI-9088686;
CC Q96NT3-2; Q5T751: LCE1C; NbExp=3; IntAct=EBI-11978177, EBI-12224199;
CC Q96NT3-2; Q5TA79: LCE2A; NbExp=3; IntAct=EBI-11978177, EBI-10246607;
CC Q96NT3-2; O14633: LCE2B; NbExp=4; IntAct=EBI-11978177, EBI-11478468;
CC Q96NT3-2; Q5TA82: LCE2D; NbExp=3; IntAct=EBI-11978177, EBI-10246750;
CC Q96NT3-2; Q9UBR4-2: LHX3; NbExp=3; IntAct=EBI-11978177, EBI-12039345;
CC Q96NT3-2; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-11978177, EBI-739832;
CC Q96NT3-2; Q13163: MAP2K5; NbExp=3; IntAct=EBI-11978177, EBI-307294;
CC Q96NT3-2; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-11978177, EBI-16439278;
CC Q96NT3-2; Q6PF18: MORN3; NbExp=3; IntAct=EBI-11978177, EBI-9675802;
CC Q96NT3-2; Q8NDC4: MORN4; NbExp=3; IntAct=EBI-11978177, EBI-10269566;
CC Q96NT3-2; Q330K2-3: NDUFAF6; NbExp=3; IntAct=EBI-11978177, EBI-12957691;
CC Q96NT3-2; Q96IV0: NGLY1; NbExp=3; IntAct=EBI-11978177, EBI-6165879;
CC Q96NT3-2; Q9H0N5: PCBD2; NbExp=3; IntAct=EBI-11978177, EBI-634289;
CC Q96NT3-2; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-11978177, EBI-11956269;
CC Q96NT3-2; Q99471: PFDN5; NbExp=3; IntAct=EBI-11978177, EBI-357275;
CC Q96NT3-2; P25786: PSMA1; NbExp=3; IntAct=EBI-11978177, EBI-359352;
CC Q96NT3-2; Q03431: PTH1R; NbExp=3; IntAct=EBI-11978177, EBI-2860297;
CC Q96NT3-2; Q2I0M5: RSPO4; NbExp=3; IntAct=EBI-11978177, EBI-12821217;
CC Q96NT3-2; Q13761-2: RUNX3; NbExp=3; IntAct=EBI-11978177, EBI-12145465;
CC Q96NT3-2; Q6ZT89-3: SLC25A48; NbExp=3; IntAct=EBI-11978177, EBI-12065614;
CC Q96NT3-2; P49901: SMCP; NbExp=3; IntAct=EBI-11978177, EBI-750494;
CC Q96NT3-2; O43609: SPRY1; NbExp=3; IntAct=EBI-11978177, EBI-3866665;
CC Q96NT3-2; Q96PV0: SYNGAP1; NbExp=3; IntAct=EBI-11978177, EBI-2682386;
CC Q96NT3-2; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-11978177, EBI-11139477;
CC Q96NT3-2; Q7Z6R9: TFAP2D; NbExp=5; IntAct=EBI-11978177, EBI-11952651;
CC Q96NT3-2; Q9H0E2: TOLLIP; NbExp=3; IntAct=EBI-11978177, EBI-74615;
CC Q96NT3-2; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-11978177, EBI-5235829;
CC Q96NT3-2; O14817: TSPAN4; NbExp=3; IntAct=EBI-11978177, EBI-8652667;
CC Q96NT3-2; Q99757: TXN2; NbExp=3; IntAct=EBI-11978177, EBI-2932492;
CC Q96NT3-2; Q6EMK4: VASN; NbExp=3; IntAct=EBI-11978177, EBI-10249550;
CC Q96NT3-2; B2RXF5: ZBTB42; NbExp=3; IntAct=EBI-11978177, EBI-12287587;
CC Q96NT3-2; Q8WW36: ZCCHC13; NbExp=3; IntAct=EBI-11978177, EBI-954111;
CC Q96NT3-2; P15622-3: ZNF250; NbExp=5; IntAct=EBI-11978177, EBI-10177272;
CC Q96NT3-2; Q8N720: ZNF655; NbExp=3; IntAct=EBI-11978177, EBI-625509;
CC Q96NT3-2; P0CH99: ZNF705D; NbExp=3; IntAct=EBI-11978177, EBI-12957159;
CC Q96NT3-2; Q9Y2P0: ZNF835; NbExp=3; IntAct=EBI-11978177, EBI-5667516;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q96NT3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96NT3-2; Sequence=VSP_044730;
CC Name=3;
CC IsoId=Q96NT3-3; Sequence=VSP_055753, VSP_044730;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB68411.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK054681; BAB70791.1; -; mRNA.
DR EMBL; AK098754; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AP000356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471095; EAW59667.1; -; Genomic_DNA.
DR EMBL; BC002924; AAH02924.2; -; mRNA.
DR EMBL; BC070109; AAH70109.1; -; mRNA.
DR EMBL; AB049215; BAB68411.1; ALT_INIT; Genomic_DNA.
DR CCDS; CCDS33621.1; -. [Q96NT3-1]
DR CCDS; CCDS63426.1; -. [Q96NT3-2]
DR CCDS; CCDS63427.1; -. [Q96NT3-3]
DR RefSeq; NP_001271180.1; NM_001284251.1.
DR RefSeq; NP_001271181.1; NM_001284252.1. [Q96NT3-3]
DR RefSeq; NP_001271183.1; NM_001284254.1. [Q96NT3-2]
DR RefSeq; NP_001271184.1; NM_001284255.1.
DR RefSeq; NP_001271185.1; NM_001284256.1.
DR RefSeq; NP_001271186.1; NM_001284257.1.
DR RefSeq; NP_113632.2; NM_031444.3. [Q96NT3-1]
DR AlphaFoldDB; Q96NT3; -.
DR BioGRID; 123697; 91.
DR IntAct; Q96NT3; 78.
DR MINT; Q96NT3; -.
DR STRING; 9606.ENSP00000479370; -.
DR iPTMnet; Q96NT3; -.
DR PhosphoSitePlus; Q96NT3; -.
DR BioMuta; GUCD1; -.
DR DMDM; 143811383; -.
DR EPD; Q96NT3; -.
DR jPOST; Q96NT3; -.
DR MassIVE; Q96NT3; -.
DR MaxQB; Q96NT3; -.
DR PaxDb; Q96NT3; -.
DR PeptideAtlas; Q96NT3; -.
DR PRIDE; Q96NT3; -.
DR ProteomicsDB; 6066; -.
DR ProteomicsDB; 77555; -. [Q96NT3-1]
DR Antibodypedia; 9753; 86 antibodies from 14 providers.
DR DNASU; 83606; -.
DR Ensembl; ENST00000398245.8; ENSP00000381297.4; ENSG00000138867.17. [Q96NT3-2]
DR Ensembl; ENST00000404664.7; ENSP00000384121.3; ENSG00000138867.17. [Q96NT3-3]
DR Ensembl; ENST00000407471.7; ENSP00000386076.3; ENSG00000138867.17. [Q96NT3-1]
DR Ensembl; ENST00000435822.6; ENSP00000405985.1; ENSG00000138867.17. [Q96NT3-2]
DR GeneID; 83606; -.
DR KEGG; hsa:83606; -.
DR MANE-Select; ENST00000435822.6; ENSP00000405985.1; NM_001284254.2; NP_001271183.1. [Q96NT3-2]
DR UCSC; uc003aah.4; human. [Q96NT3-1]
DR CTD; 83606; -.
DR DisGeNET; 83606; -.
DR GeneCards; GUCD1; -.
DR HGNC; HGNC:14237; GUCD1.
DR HPA; ENSG00000138867; Low tissue specificity.
DR MIM; 619171; gene.
DR neXtProt; NX_Q96NT3; -.
DR OpenTargets; ENSG00000138867; -.
DR PharmGKB; PA25882; -.
DR VEuPathDB; HostDB:ENSG00000138867; -.
DR eggNOG; KOG4621; Eukaryota.
DR GeneTree; ENSGT00390000000571; -.
DR HOGENOM; CLU_064395_0_1_1; -.
DR InParanoid; Q96NT3; -.
DR OMA; KRYAGHY; -.
DR OrthoDB; 1348354at2759; -.
DR PhylomeDB; Q96NT3; -.
DR TreeFam; TF324062; -.
DR PathwayCommons; Q96NT3; -.
DR SignaLink; Q96NT3; -.
DR BioGRID-ORCS; 83606; 7 hits in 1075 CRISPR screens.
DR ChiTaRS; GUCD1; human.
DR GenomeRNAi; 83606; -.
DR Pharos; Q96NT3; Tdark.
DR PRO; PR:Q96NT3; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q96NT3; protein.
DR Bgee; ENSG00000138867; Expressed in apex of heart and 180 other tissues.
DR ExpressionAtlas; Q96NT3; baseline and differential.
DR Genevisible; Q96NT3; HS.
DR InterPro; IPR018616; GUCD1.
DR PANTHER; PTHR31400; PTHR31400; 1.
DR Pfam; PF09778; Guanylate_cyc_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..240
FT /note="Protein GUCD1"
FT /id="PRO_0000079574"
FT VAR_SEQ 1..13
FT /note="MRTEAEAAGPPLE -> MTGPGGRRNDPWGRQRAREGAHTSKHPTPRTGWTA
FT RRRRGAWALRPGTAGGWAKGQDFPSQFHLLIPAP (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055753"
FT VAR_SEQ 210..211
FT /note="PG -> R (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_044730"
FT CONFLICT 12..13
FT /note="LE -> AP (in Ref. 3; AAH02924)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 240 AA; 27207 MW; 164875E32F70D1E0 CRC64;
MRTEAEAAGP PLEPGDFVQL PVPVIQQLYH WDCGLACSRM VLRYLGQLDD SEFERALQKL
QLTRSIWTID LAYLMHHFGV RHRFCTQTLG VDKGYKNQSF YRKHFDTEET RVNQLFAQAK
ACKVLVEKCT VSVKDIQAHL AQGHVAIVLV NSGVLHCDLC SSPVKYCCFT PSGHHCFCRT
PDYQGHFIVL RGYNRATGCI FYNNPAYADP GMCSTSISNF EEARTSYGTD EDILFVYLDS
