ID   GUDP_PSEPU              Reviewed;         456 AA.
AC   P42205;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Probable galactarate/D-glucarate transporter GudP {ECO:0000250|UniProtKB:Q46916};
GN   Name=gudP;
OS   Pseudomonas putida (Arthrobacter siderocapsulatus).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=303;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=pp3;
RA   Burlingame R.P., Lauer G.D., Platz J.G., Rudd E.A., Ally A., Ally D.,
RA   Backman K.C.;
RT   "Nucleotide sequence of genes for glucarate dehydratase and 5-keto-4-
RT   deoxyglucarate dehydratase from Pseudomonas putida pp3.";
RL   Submitted (JUN-1992) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probably involved in the uptake of galactarate and/or D-
CC       glucarate. {ECO:0000250|UniProtKB:Q46916}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=galactarate(in) + H(+)(in) = galactarate(out) + H(+)(out);
CC         Xref=Rhea:RHEA:28478, ChEBI:CHEBI:15378, ChEBI:CHEBI:16537;
CC         Evidence={ECO:0000250|UniProtKB:Q46916};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucarate(in) + H(+)(in) = D-glucarate(out) + H(+)(out);
CC         Xref=Rhea:RHEA:28474, ChEBI:CHEBI:15378, ChEBI:CHEBI:30612;
CC         Evidence={ECO:0000250|UniProtKB:Q46916};
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:Q46916}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Phthalate
CC       permease family. {ECO:0000305}.
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DR   EMBL; M69160; AAA25867.1; -; Genomic_DNA.
DR   PIR; S27616; S27616.
DR   AlphaFoldDB; P42205; -.
DR   SMR; P42205; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR000849; Sugar_P_transporter.
DR   Pfam; PF07690; MFS_1; 2.
DR   PIRSF; PIRSF002808; Hexose_phosphate_transp; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..456
FT                   /note="Probable galactarate/D-glucarate transporter GudP"
FT                   /id="PRO_0000121386"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        246..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        280..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        317..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        341..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        381..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        408..428
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   456 AA;  49779 MW;  B5B80BB6608C581D CRC64;
     MQEPKQTRVR YLILLMLFLV TTINYADRAT ISIAGSSIQK DFGLDAVTLG YIFSAFGWAY
     VLGQIPGGWL LDRFGSKKVY AGSIFTWSLF TLLQGYIGEF GISTAVVLLF LLRFMVGLAE
     APSFPGNARI VASWFPTKER GTASAIFNSA QYFATRAVRA LDGLDRLHLR LAARVHRHGR
     PGHCVLAHLV DGDLRAERSP AGYAAEVRSS PHGGLVDLED SKDKKDGGPK WDYIRQLLTN
     RMMMGIYLGQ FCINALTYFF LTWFPVYLVQ ERGMTILKAG IIASLPAICG FLGGVLGGVI
     SDTLLRRGNS LSVARKTPIV CGMVLSMSMI ICNYVDADWM VVCFMALAFF GKAIGALGWA
     VVSDTSPKQI AGLSGGLFNT FGNLSSISTP IIIGYIIAAT GVSKWRWSSW VPTHSFAAIS
     YLFIVGEINR IELKGVTDEP ATTAHPGELL PTTRKV