ID   GUEN_SYLGU              Reviewed;          26 AA.
AC   P84859;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=Guentherin;
DE   AltName: Full=AMP-3;
OS   Sylvirana guentheri (Gunther's frog) (Rana guentheri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Sylvirana.
OX   NCBI_TaxID=110109;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   MASS SPECTROMETRY.
RC   TISSUE=Skin secretion {ECO:0000269|PubMed:16979798};
RX   PubMed=16979798; DOI=10.1016/j.peptides.2006.08.007;
RA   Zhou J., McClean S., Thompson A., Zhang Y., Shaw C., Rao P., Bjourson A.J.;
RT   "Purification and characterization of novel antimicrobial peptides from the
RT   skin secretion of Hylarana guentheri.";
RL   Peptides 27:3077-3084(2006).
CC   -!- FUNCTION: Antimicrobial peptide. Active against the Gram-positive
CC       bacteria S.aureus FDA209P (MIC=35.5 ug/ml) and B.subtilis ATCC 6633
CC       (MIC>64 ug/ml), but not active against the Gram-negative bacterium
CC       E.coli or the fungus C.albicans. {ECO:0000269|PubMed:16979798}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16979798}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:16979798}.
CC   -!- MASS SPECTROMETRY: Mass=3138.8; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:16979798};
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DR   AlphaFoldDB; P84859; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Direct protein sequencing; Secreted.
FT   PEPTIDE         1..26
FT                   /note="Guentherin"
FT                   /evidence="ECO:0000269|PubMed:16979798"
FT                   /id="PRO_0000271189"
SQ   SEQUENCE   26 AA;  3141 MW;  DC58C59657393065 CRC64;
     VIDDLKKVAK KVRRELLCKK HHKKLN