AMT2_ARCFU
ID AMT2_ARCFU Reviewed; 468 AA.
AC O28528;
DT 02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Ammonium transporter Amt2 {ECO:0000305};
GN Name=amt2 {ECO:0000305};
GN OrderedLocusNames=AF_1746 {ECO:0000312|EMBL:AAB89503.1};
OS Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC
OS 100126 / VC-16).
OC Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC Archaeoglobus.
OX NCBI_TaxID=224325;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX PubMed=9389475; DOI=10.1038/37052;
RA Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A.,
RA Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L.,
RA Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D.,
RA Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F.,
RA Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N.,
RA Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R.,
RA Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D.,
RA Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P.,
RA Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M.,
RA Smith H.O., Woese C.R., Venter J.C.;
RT "The complete genome sequence of the hyperthermophilic, sulphate-reducing
RT archaeon Archaeoglobus fulgidus.";
RL Nature 390:364-370(1997).
CC -!- FUNCTION: Involved in the uptake of ammonium/ammonia (NH(4)(+)/NH(3)).
CC Transport is electrogenic. {ECO:0000250|UniProtKB:O29285}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000250|UniProtKB:O29285}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O29285};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the ammonia transporter channel (TC 1.A.11.2)
CC family. {ECO:0000305}.
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DR EMBL; AE000782; AAB89503.1; -; Genomic_DNA.
DR PIR; A69468; A69468.
DR AlphaFoldDB; O28528; -.
DR SMR; O28528; -.
DR STRING; 224325.AF_1746; -.
DR TCDB; 1.A.11.2.7; the ammonium transporter channel (amt) family.
DR EnsemblBacteria; AAB89503; AAB89503; AF_1746.
DR KEGG; afu:AF_1746; -.
DR eggNOG; arCOG04397; Archaea.
DR HOGENOM; CLU_000445_33_1_2; -.
DR OMA; IWLSIMS; -.
DR OrthoDB; 66605at2157; -.
DR PhylomeDB; O28528; -.
DR Proteomes; UP000002199; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0008519; F:ammonium transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.10.3430.10; -; 1.
DR InterPro; IPR029020; Ammonium/urea_transptr.
DR InterPro; IPR001905; Ammonium_transpt.
DR InterPro; IPR018047; Ammonium_transpt_CS.
DR InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR InterPro; IPR002229; RhesusRHD.
DR Pfam; PF00909; Ammonium_transp; 1.
DR PRINTS; PR00342; RHESUSRHD.
DR TIGRFAMs; TIGR00836; amt; 1.
DR PROSITE; PS01219; AMMONIUM_TRANSP; 1.
PE 3: Inferred from homology;
KW Ammonia transport; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..468
FT /note="Ammonium transporter Amt2"
FT /id="PRO_0000453006"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 321..341
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 350..370
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 400..420
FT /note="Helical"
FT /evidence="ECO:0000255"
FT SITE 201
FT /note="Twin-His motif. Important for optimum substrate
FT conductance"
FT /evidence="ECO:0000250|UniProtKB:P69681"
FT SITE 356
FT /note="Twin-His motif. Important for optimum substrate
FT conductance"
FT /evidence="ECO:0000250|UniProtKB:P69681"
SQ SEQUENCE 468 AA; 49591 MW; AEA00AF0AE2874FF CRC64;
MVGRMCVAVL IVLLLVATAG ADPNGAETLK ENPELPVDFV WALICGFLVM FMQAGFAMLE
AGFSRAKNVA NVMMKNLMDF AVGSLAFFAV GFALMMGADW QGIAGTTGWF LAGESYDVST
IELWFFMLVF AATAATIVSG SIAERPKFSV YLVYSAVVSA VIYPIYGHWL WGGGWLSSSE
FMVKLGGGYG ALDFAGSGVV HALGGYIALA AVMLLGPRLG KYDSDGNPRA IPGHNLAFAV
IGTFILWFGW FGFNAGSTLS AHELRVSIIA SNTNLAAAAG AVTAMAITWL RNGKPDVGMT
CNGAVAGLVA ITAPCAWVQP WSSVVIGTIA GFIATYGYWW LEKRGLDDVV GAIPVHGFSG
TWGLIALGIF ADGSYGLYAT ESPLVTGLLY GNWGFFIVQL ISAIVNFAWA FGTGFALFWI
LKKVIGIRVS PEEEMLGLDI AEHAAVAYPN FVCTETELPL AMKQGGGR
