ID   AMT2_CAEEL              Reviewed;         515 AA.
AC   Q20605;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2012, sequence version 3.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Putative ammonium transporter 2;
GN   Name=amt-2; ORFNames=F49E11.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION.
RX   PubMed=17608836; DOI=10.1111/j.1474-9726.2007.00302.x;
RA   Kim Y., Sun H.;
RT   "Functional genomic approach to identify novel genes involved in the
RT   regulation of oxidative stress resistance and animal lifespan.";
RL   Aging Cell 6:489-503(2007).
CC   -!- FUNCTION: Involved in the uptake of ammonia (Probable). Implicated in
CC       aging. {ECO:0000269|PubMed:17608836, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ammonia transporter channel (TC 1.A.11.2)
CC       family. {ECO:0000305}.
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DR   EMBL; Z70308; CAA94345.3; -; Genomic_DNA.
DR   PIR; T22433; T22433.
DR   RefSeq; NP_502496.3; NM_070095.3.
DR   AlphaFoldDB; Q20605; -.
DR   SMR; Q20605; -.
DR   STRING; 6239.F49E11.3; -.
DR   TCDB; 1.A.11.2.10; the ammonium transporter channel (amt) family.
DR   PaxDb; Q20605; -.
DR   EnsemblMetazoa; F49E11.3.1; F49E11.3.1; WBGene00000134.
DR   GeneID; 186047; -.
DR   KEGG; cel:CELE_F49E11.3; -.
DR   UCSC; F49E11.3; c. elegans.
DR   CTD; 186047; -.
DR   WormBase; F49E11.3; CE45919; WBGene00000134; amt-2.
DR   eggNOG; KOG0682; Eukaryota.
DR   GeneTree; ENSGT00530000064546; -.
DR   HOGENOM; CLU_000445_33_1_1; -.
DR   InParanoid; Q20605; -.
DR   OMA; CAGSDVM; -.
DR   OrthoDB; 910733at2759; -.
DR   PhylomeDB; Q20605; -.
DR   PRO; PR:Q20605; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00000134; Expressed in pharyngeal muscle cell (C elegans) and 2 other tissues.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0008519; F:ammonium transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0007568; P:aging; IMP:UniProtKB.
DR   GO; GO:0097272; P:ammonium homeostasis; IBA:GO_Central.
DR   GO; GO:0072488; P:ammonium transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.10.3430.10; -; 1.
DR   InterPro; IPR029020; Ammonium/urea_transptr.
DR   InterPro; IPR001905; Ammonium_transpt.
DR   InterPro; IPR018047; Ammonium_transpt_CS.
DR   InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR   Pfam; PF00909; Ammonium_transp; 1.
DR   TIGRFAMs; TIGR00836; amt; 1.
DR   PROSITE; PS01219; AMMONIUM_TRANSP; 1.
PE   3: Inferred from homology;
KW   Ammonia transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..515
FT                   /note="Putative ammonium transporter 2"
FT                   /id="PRO_0000139752"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        266..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        321..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        346..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        381..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        404..424
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   515 AA;  56840 MW;  DE105498817E087B CRC64;
     MNTLQNLTLK MDRQPTIRMK PDKQLDCSLS QDDGVWMMAS SFIIFTMTAG FGLLESGRVS
     SKDEVNCMVK NVFDVIFGGL AYWMFGYGLT FGDSKHQLGR YVGFGDFFFD PERVSDDDST
     DEKGISYSLF IFQMSFATTT STIVSAGMSE RIHLKSHCFI SFFITLVHSV AGHWVWDQEG
     VFRMMGVVDS AGCSAVHLVG GVSGLVATLY LKPRRNRFAK NGIRTVSDPT KAILGFLMIW
     WGWLAFNTSS NYAVTHGQWT EGMRSAVGTI LASAGGGVVT VIITRLSTKK IQMDMLIDGM
     LASLVASTGG CLYFTPWQAT LVGAIGSSLA LAAYPVTEWL KIDDPVGVFP VHVVGSIWGM
     IAPAIFVYRR PMNFGPPECD FQTSDEINGL LYGGGFYLLF LQSFVILVIG TYSAICAFII
     LFLIHHSPVG LRVDKYTEEL GADLIEHGLA GFNVMTYTIE KKLDTKTLSA VLMIIVRWRA
     KAKLGAQRRK KIHDSGSVAP QQAESVEMNV IHRRH