ID   GULP1_DANRE             Reviewed;         300 AA.
AC   Q32PV0; A2AI65; B0S741; B0S742;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=PTB domain-containing engulfment adapter protein 1;
DE   AltName: Full=Cell death protein 6 homolog;
DE   AltName: Full=PTB domain adapter protein CED-6;
GN   Name=gulp1; Synonyms=ced6; ORFNames=si:ch211-198b21.4, si:xx-35d8.1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Larva;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as an adapter protein. Required for efficient
CC       phagocytosis of apoptotic cells. May play a role in the internalization
CC       and endosomal trafficking of various lrp1 ligands (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q32PV0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q32PV0-2; Sequence=VSP_037975;
CC   -!- SIMILARITY: Belongs to the ced-6 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAM13101.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AL732386; CAM13101.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CR752643; CAQ14641.1; -; Genomic_DNA.
DR   EMBL; BX640465; CAQ14641.1; JOINED; Genomic_DNA.
DR   EMBL; CR752643; CAQ14642.1; -; Genomic_DNA.
DR   EMBL; BX640465; CAQ14642.1; JOINED; Genomic_DNA.
DR   EMBL; BX640465; CAQ15243.1; -; Genomic_DNA.
DR   EMBL; CR752643; CAQ15243.1; JOINED; Genomic_DNA.
DR   EMBL; BX640465; CAQ15244.1; -; Genomic_DNA.
DR   EMBL; CR752643; CAQ15244.1; JOINED; Genomic_DNA.
DR   EMBL; BC107973; AAI07974.1; -; mRNA.
DR   RefSeq; NP_001007183.1; NM_001007182.3. [Q32PV0-1]
DR   AlphaFoldDB; Q32PV0; -.
DR   SMR; Q32PV0; -.
DR   Ensembl; ENSDART00000002027; ENSDARP00000000920; ENSDARG00000001733. [Q32PV0-1]
DR   Ensembl; ENSDART00000138133; ENSDARP00000114797; ENSDARG00000001733. [Q32PV0-2]
DR   Ensembl; ENSDART00000191186; ENSDARP00000156594; ENSDARG00000001733. [Q32PV0-1]
DR   Ensembl; ENSDART00000192224; ENSDARP00000150288; ENSDARG00000001733. [Q32PV0-1]
DR   GeneID; 368404; -.
DR   KEGG; dre:368404; -.
DR   CTD; 368404; -.
DR   ZFIN; ZDB-GENE-030616-21; gulp1a.
DR   GeneTree; ENSGT00940000156186; -.
DR   HOGENOM; CLU_024530_0_0_1; -.
DR   InParanoid; Q32PV0; -.
DR   OMA; CLDPVDS; -.
DR   OrthoDB; 920757at2759; -.
DR   PhylomeDB; Q32PV0; -.
DR   TreeFam; TF314159; -.
DR   PRO; PR:Q32PV0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 9.
DR   Bgee; ENSDARG00000001733; Expressed in swim bladder and 30 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   Pfam; PF00640; PID; 1.
DR   SMART; SM00462; PTB; 1.
DR   PROSITE; PS01179; PID; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Apoptosis; Coiled coil; Cytoplasm; Phagocytosis;
KW   Reference proteome; Transport.
FT   CHAIN           1..300
FT                   /note="PTB domain-containing engulfment adapter protein 1"
FT                   /id="PRO_0000296682"
FT   DOMAIN          21..176
FT                   /note="PID"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00148"
FT   COILED          160..199
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         201
FT                   /note="P -> PLLHINSSNEAYMLQRPSSLFWCHNVTSFSCLEISSVTLTPMSSPDS
FT                   NLSAGLLTPPPTKPALSKPPGGASVPRHS (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_037975"
SQ   SEQUENCE   300 AA;  33860 MW;  A5B950DEDBE76C34 CRC64;
     MNRAFNRKKD KSWMHTPEAL AKHFIPYNAK FLGNTEVDQP KGTEVVKDAV RKLKFQRHIK
     KSEGQKLPKV ELQISIYGVK ILDPKSKEVQ YNCQLHRISF CADDKTDKRI FTFICKDSES
     NKHLCYVFDS EKCAEEITLT IGQAFDLAYK KFLESGGKDV ETRKQIGGLQ KRIQDLETEN
     VELKKQLQVL EEQLMIAQVP PGNSMSSKSP TDIFDMVPFS PMTPLVPLPA SNGSAPPPPA
     RPTEIRRDLF GAEPFDPFTC GAADFPPDIQ SKLDEMQEGF KMGLTVEGTV FSLDPLEGRC