ID   AMT3_CAEEL              Reviewed;         687 AA.
AC   Q21565;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   11-APR-2003, sequence version 2.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Putative ammonium transporter 3;
GN   Name=amt-3; ORFNames=M195.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Involved in the uptake of ammonia. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ammonia transporter channel (TC 1.A.11.2)
CC       family. {ECO:0000305}.
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DR   EMBL; Z66498; CAA91293.2; -; Genomic_DNA.
DR   PIR; T23804; T23804.
DR   RefSeq; NP_495761.2; NM_063360.6.
DR   AlphaFoldDB; Q21565; -.
DR   SMR; Q21565; -.
DR   STRING; 6239.M195.3; -.
DR   PaxDb; Q21565; -.
DR   EnsemblMetazoa; M195.3.1; M195.3.1; WBGene00000135.
DR   GeneID; 174338; -.
DR   KEGG; cel:CELE_M195.3; -.
DR   UCSC; M195.3; c. elegans.
DR   CTD; 174338; -.
DR   WormBase; M195.3; CE32912; WBGene00000135; amt-3.
DR   eggNOG; KOG0682; Eukaryota.
DR   GeneTree; ENSGT00530000064546; -.
DR   HOGENOM; CLU_000445_33_1_1; -.
DR   InParanoid; Q21565; -.
DR   OMA; SSIWGMI; -.
DR   OrthoDB; 910733at2759; -.
DR   PhylomeDB; Q21565; -.
DR   PRO; PR:Q21565; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00000135; Expressed in larva and 2 other tissues.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0008519; F:ammonium transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0097272; P:ammonium homeostasis; IBA:GO_Central.
DR   GO; GO:0072488; P:ammonium transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.10.3430.10; -; 1.
DR   InterPro; IPR029020; Ammonium/urea_transptr.
DR   InterPro; IPR001905; Ammonium_transpt.
DR   InterPro; IPR018047; Ammonium_transpt_CS.
DR   InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR   Pfam; PF00909; Ammonium_transp; 1.
DR   TIGRFAMs; TIGR00836; amt; 1.
DR   PROSITE; PS01219; AMMONIUM_TRANSP; 1.
PE   3: Inferred from homology;
KW   Ammonia transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..687
FT                   /note="Putative ammonium transporter 3"
FT                   /id="PRO_0000139753"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        299..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        323..343
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        352..372
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        404..424
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          521..544
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          549..568
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          592..687
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        597..667
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   687 AA;  73938 MW;  90EA97A928918E01 CRC64;
     MAGPEGSIFN ASAMQIVQIH HYAEGSVTPE VDKLYQDDAV WIISSSFIIF TMHSGFGLLE
     SGSVSAKDEV NIMVKNVVDV VFGGLSYWSC GFGFSYGDIP EWRNPYVGFG KFFYDPTRDY
     GTRETINQEG WSYASFLFQL SLATTASTIV SGAVAERAKL KSYILLGCIV ILIQALPAHW
     VWDKEGVFYK KGVVDFAGCS AVHLVGGIIG LIATVFLKPR RNRFNEDSVH QMSSPTNALL
     GTFLLWWGWF GINAGSVWGI TGGRWRLGAR AAVATIMASI GGGATAITIS FVKTKKLQVN
     FLINGILSSI VSITAICAVS RPWHALVIGS ISSVFSIAVL PLLDRLHIDD PVGIVPIHLT
     SSIWGMIAVG IFCEEDKYLG SATNNRSGLL YSWSFELLWV QLQCTAAILI YSATTGFLAL
     FLISKSPLGL RVTDYEEQIG ADVIEHGLAG TNVARYVLEK PLSTRTFQTV TKAITKWKML
     AKKKSRQKRM EAAKLKRQEE QETFTNGTAI ANGNGNVLHH RTNATESNGT GAPKRSNGPA
     FNNQITPLAV SSTVSTARNG PSTGRRTEST AIEIEQPIEA VPPEVVAAAV LPPEERPGPS
     TNSNVSIEAS VEKSPSSSTS RRSISIRSSP SIHTVSAIST AAPDSRPSTA SATSIISKKS
     SKNSTVGKFV KAPAPRALSP PDNNPPV