GUR3_CAEEL
ID GUR3_CAEEL Reviewed; 447 AA.
AC O18280; Q963E7;
DT 15-FEB-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 3.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Gustatory receptor family protein 3;
GN Name=gur-3 {ECO:0000312|WormBase:ZC504.5};
GN ORFNames=ZC504.5 {ECO:0000312|WormBase:ZC504.5};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Robertson H.M.;
RT "Gustatory related receptors in nematodes.";
RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=25640076; DOI=10.1016/j.neuron.2014.12.061;
RA Bhatla N., Horvitz H.R.;
RT "Light and hydrogen peroxide inhibit C. elegans Feeding through gustatory
RT receptor orthologs and pharyngeal neurons.";
RL Neuron 85:804-818(2015).
RN [4]
RP FUNCTION, AND MUTAGENESIS OF TYR-79.
RX PubMed=27863243; DOI=10.1016/j.cell.2016.10.053;
RA Gong J., Yuan Y., Ward A., Kang L., Zhang B., Wu Z., Peng J., Feng Z.,
RA Liu J., Xu X.Z.;
RT "The C. elegans taste receptor homolog LITE-1 is a photoreceptor.";
RL Cell 167:1252-1263(2016).
RN [5]
RP FUNCTION.
RX PubMed=27849618; DOI=10.1073/pnas.1605769113;
RA Goya M.E., Romanowski A., Caldart C.S., Benard C.Y., Golombek D.A.;
RT "Circadian rhythms identified in Caenorhabditis elegans by in vivo long-
RT term monitoring of a bioluminescent reporter.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:E7837-E7845(2016).
CC -!- FUNCTION: Chemoreceptor involved in light-induced avoidance behavior
CC (PubMed:25640076). Probably acts as a molecular sensor in I2 pharyngeal
CC neurons, required for the inhibition of feeding in response to light
CC and hydrogen peroxide (PubMed:25640076). Involved in circadian rhythms,
CC probably by acting as a light sensor (PubMed:27849618). In contrast to
CC lite-1, does not act as a photoreceptor (PubMed:27863243).
CC {ECO:0000269|PubMed:25640076, ECO:0000269|PubMed:27849618,
CC ECO:0000269|PubMed:27863243}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in I2 pharyngeal neurons.
CC {ECO:0000269|PubMed:25640076}.
CC -!- SIMILARITY: Belongs to the insect chemoreceptor superfamily. Gustatory
CC receptor (GR) family. {ECO:0000305}.
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DR EMBL; AF387606; AAK70489.1; -; mRNA.
DR EMBL; BX284606; CAA90343.3; -; Genomic_DNA.
DR PIR; T27621; T27621.
DR RefSeq; NP_509743.2; NM_077342.4.
DR AlphaFoldDB; O18280; -.
DR STRING; 6239.ZC504.5; -.
DR TCDB; 1.A.69.3.8; the heteromeric odorant receptor channel (horc) family.
DR PaxDb; O18280; -.
DR EnsemblMetazoa; ZC504.5.1; ZC504.5.1; WBGene00001804.
DR GeneID; 181245; -.
DR KEGG; cel:CELE_ZC504.5; -.
DR UCSC; ZC504.5; c. elegans.
DR CTD; 181245; -.
DR WormBase; ZC504.5; CE30223; WBGene00001804; gur-3.
DR eggNOG; ENOG502SZ0X; Eukaryota.
DR HOGENOM; CLU_625900_0_0_1; -.
DR InParanoid; O18280; -.
DR OMA; ERAGECN; -.
DR OrthoDB; 653963at2759; -.
DR PhylomeDB; O18280; -.
DR PRO; PR:O18280; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00001804; Expressed in pharyngeal muscle cell (C elegans).
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; HDA:WormBase.
DR GO; GO:0050909; P:sensory perception of taste; IEA:InterPro.
DR InterPro; IPR013604; 7TM_chemorcpt.
DR PANTHER; PTHR21143; PTHR21143; 1.
DR Pfam; PF08395; 7tm_7; 1.
PE 1: Evidence at protein level;
KW Membrane; Receptor; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..447
FT /note="Gustatory receptor family protein 3"
FT /id="PRO_0000439037"
FT TOPO_DOM 1..69
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..116
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..171
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 193..211
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 233..292
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 293..313
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 314..328
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 329..349
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 350..405
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 406..426
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 427..447
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT MUTAGEN 79
FT /note="Y->W: Induces sensitivity to UV-B light."
FT /evidence="ECO:0000269|PubMed:27863243"
FT CONFLICT 7
FT /note="N -> S (in Ref. 1; AAK70489)"
FT /evidence="ECO:0000305"
FT CONFLICT 62
FT /note="H -> L (in Ref. 1; AAK70489)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 447 AA; 51228 MW; E916BEAA7C14C80C CRC64;
MTITASNTLE FKWTSPRSSR SSFRTTTDAE QKISIDMSNT YCDQVLGPLY SYMMVLGLNH
THSSARNTMF KWPLTIYNYL TLAILTAATI RRISQIKQKS ATNEEKDAAF HVLNPTFVLT
LCHALLMFSG LAAGFLLLKL QKQREKMYHV LDQGLGRNRN EEHDSHHFKL NKLFISISFS
FAAALSFVQI ATKMRYLDLP DTPDLINRKI YFVILEGYVI FIASSCISLV AILFFQLCRI
LQFSIGQLIE EMVPKEKEEC PLPEQSLQQI HDVQIHYQEI SNAKLYIEQN FSFSLFYTYG
CCIPLTCLLG YIAFRNGIQA DMAETFSVAI WLTNTMLALM LFSIPAFMIA EEGDKLLTAS
FKMYHETLCE ERDLLVLSQM SFLSFQMHAT KLTLTAGNFF MMNRKIMISL FSAIFTYFLI
LVQFDAEKER AGECNNQSRV LIVQPPV
