GUSP1_HUMAN
ID GUSP1_HUMAN Reviewed; 140 AA.
AC Q15486; A6NLY8; A8K1B7; Q969T8; Q9BUH2;
DT 05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 3.
DT 25-MAY-2022, entry version 153.
DE RecName: Full=Putative inactive beta-glucuronidase-like protein SMA3;
GN Name=GUSBP1; Synonyms=SMA3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Fetal brain;
RX PubMed=7977382;
RA Theodosiou A.M., Morrison K.E., Nesbit A.M., Daniels R.J., Campbell L.,
RA Francis M.J., Christodoulou Z., Davies K.E.;
RT "Complex repetitive arrangements of gene sequence in the candidate region
RT of the spinal muscular atrophy gene in 5q13.";
RL Am. J. Hum. Genet. 55:1209-1217(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
CC -!- INTERACTION:
CC Q15486; P07550: ADRB2; NbExp=3; IntAct=EBI-712457, EBI-491169;
CC Q15486; P28329-3: CHAT; NbExp=3; IntAct=EBI-712457, EBI-25837549;
CC Q15486; G5E9A7: DMWD; NbExp=3; IntAct=EBI-712457, EBI-10976677;
CC Q15486; P22607: FGFR3; NbExp=4; IntAct=EBI-712457, EBI-348399;
CC Q15486; P06396: GSN; NbExp=3; IntAct=EBI-712457, EBI-351506;
CC Q15486; P11021: HSPA5; NbExp=3; IntAct=EBI-712457, EBI-354921;
CC Q15486; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-712457, EBI-5235340;
CC Q15486; Q9Y649; NbExp=3; IntAct=EBI-712457, EBI-25900580;
CC -!- TISSUE SPECIFICITY: Ubiquitous.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. Compared to other
CC members of the glycosyl hydrolase 2 family this putative protein is
CC truncated in both the N- and C-terminal regions and thus probably lacks
CC enzymatic activity. {ECO:0000305}.
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DR EMBL; X83299; CAA58278.1; -; mRNA.
DR EMBL; AK289832; BAF82521.1; -; mRNA.
DR EMBL; AK315849; BAF98740.1; -; mRNA.
DR EMBL; BT006760; AAP35406.1; -; mRNA.
DR EMBL; AL009030; CAC69829.1; -; Genomic_DNA.
DR EMBL; AL009030; CAC69830.1; -; Genomic_DNA.
DR PIR; I38232; I38232.
DR RefSeq; XP_016885720.1; XM_017030231.1.
DR RefSeq; XP_016885721.1; XM_017030232.1.
DR RefSeq; XP_016885722.1; XM_017030233.1.
DR AlphaFoldDB; Q15486; -.
DR SMR; Q15486; -.
DR IntAct; Q15486; 14.
DR iPTMnet; Q15486; -.
DR PhosphoSitePlus; Q15486; -.
DR BioMuta; HGNC:13670; -.
DR DMDM; 205371787; -.
DR MassIVE; Q15486; -.
DR PeptideAtlas; Q15486; -.
DR PRIDE; Q15486; -.
DR ProteomicsDB; 60610; -.
DR GeneCards; GUSBP1; -.
DR HGNC; HGNC:13670; GUSBP1.
DR neXtProt; NX_Q15486; -.
DR InParanoid; Q15486; -.
DR PhylomeDB; Q15486; -.
DR PathwayCommons; Q15486; -.
DR SignaLink; Q15486; -.
DR ChiTaRS; GUSBP1; human.
DR GenomeRNAi; 100653061; -.
DR Pharos; Q15486; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q15486; protein.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004566; F:beta-glucuronidase activity; IBA:GO_Central.
DR GO; GO:0030246; F:carbohydrate binding; IBA:GO_Central.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0019391; P:glucuronoside catabolic process; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; TAS:ProtInc.
DR GO; GO:0001501; P:skeletal system development; TAS:ProtInc.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR SUPFAM; SSF49303; SSF49303; 1.
PE 5: Uncertain;
KW Reference proteome.
FT CHAIN 1..140
FT /note="Putative inactive beta-glucuronidase-like protein
FT SMA3"
FT /id="PRO_0000057682"
FT CONFLICT 15
FT /note="S -> L (in Ref. 1; CAA58278)"
FT /evidence="ECO:0000305"
FT CONFLICT 74
FT /note="S -> Y (in Ref. 1; CAA58278 and 3; AAP35406)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 140 AA; 15381 MW; 80CA4B489C81A48D CRC64;
MDRSNPVKPA LDYFSNRLVN YQISVKCSNQ FKLEVCLLNA ENKVVDNQAG TQGQLKVLGA
NLWWPYLMHE HPASLYSWED GDCSHQSLGP LPACDLCDQL HLRSRQGGSV CGCDPCEQLL
LLVSQLRAPG VDSAAAGRPV
